Results 51 to 60 of about 2,574 (135)
Disruption of Spike Priming in Virus Entry: Tetrandrine as a Pan‐Coronavirus Inhibitor
MedComm, Volume 6, Issue 9, September 2025.Tetrandrine inhibits the infection of HCoV‐OC43, HCoV‐229E, SARS‐CoV‐2, and its major variants by blocking virus entry. Specifically, tetrandrine breaks the interaction between TMPRSS2 and Spike, therefore suppress its priming and the following membrane fusion, and induces Spike to degradation.
Kun Wang +9 more
wiley +1 more source
Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives
Advanced Science, Volume 12, Issue 32, August 28, 2025.Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu +13 more
wiley +1 more source
Facilitating crRNA Design by Integrating DNA Interaction Features of CRISPR‐Cas12a System
Advanced Science, Volume 12, Issue 25, July 3, 2025.This study introduces a novel approach combining molecular dynamics simulations and neural network modeling to predict the Cas12a trans‐cleavage activity. By integrating sequence and molecular interaction features, prediction accuracy is enhanced, and identify key features affecting Cas12a trans‐cleavage activity.
Zhihao Yao +7 more
wiley +1 more source
Journal of Medical Virology, 2011 AbstractThe polyomaviruses KI and WU (KIPyV and WUPyV) have been identified in respiratory specimens from children with acute respiratory infections, which suggests the respiratory tract as a possible site of infection. However, the persistence of infection in the lymphoid system is unknown.
COMAR, Manola +4 more
openaire +3 more sources
Journal of Neurochemistry, Volume 169, Issue 4, April 2025.This study examines how breast cancer and psychological stress impact the hippocampal proteome, uncovering altered signalling pathways linked to mitochondrial dysfunction, impaired energy production, and altered synaptic plasticity; that is, cellular processes that are critical for memory formation and cognitive health.
Myrthe Mampay +6 more
wiley +1 more source
APMIS, Volume 133, Issue 1, January 2025.Pleomorphic adenoma (PA) is a benign salivary gland tumour that may recur or undergo malignant transformation (CXPA). Toll‐like receptors (TLR) mediate immune responses triggered by various agents such as viruses and are related to tumour formation either by stimulating or suppressing their growth, with variation across different tumour entities.
Maria K. Jauhiainen +8 more
wiley +1 more source
Plant Biotechnology Journal, Volume 22, Issue 12, Page 3326-3341, December 2024.Summary Corn leaf aphids (Rhopalosiphum maidis) are highly destructive pests of maize (Zea mays) that threaten growth and seed yield, but resources for aphid resistance are scarce. Here, we identified an aphid‐resistant maize mutant, resistance to aphids 1 (rta1), which is allelic to LIGULELESS1 (LG1).
Shijie Huang +12 more
wiley +1 more source
Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39
British Journal of Pharmacology, Volume 181, Issue 22, Page 4450-4490, November 2024.Viroporins possess important potential as antiviral targets due to their critical roles during virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine targets the M2 viroporin of influenza A virus, successful progression of other viroporin inhibitors into clinical use remains challenging.
Kira Devantier +4 more
wiley +1 more source
Beyond the Gut: The intratumoral microbiome's influence on tumorigenesis and treatment response
Cancer Communications, Volume 44, Issue 10, Page 1130-1167, October 2024.Abstract The intratumoral microbiome (TM) refers to the microorganisms in the tumor tissues, including bacteria, fungi, viruses, and so on, and is distinct from the gut microbiome and circulating microbiota. TM is strongly associated with tumorigenesis, progression, metastasis, and response to therapy.
Hao Zhang +10 more
wiley +1 more source
Approaches and methods to study wildlife cancer
Journal of Animal Ecology, Volume 93, Issue 10, Page 1410-1428, October 2024.There are still a number of challenges in collecting cancer data from wild animals. This paper provides a review of currently available methods to detect and measure cancer in wild organisms as well as the methodological limitations to be overcome to develop approaches inspired by diagnostic techniques used in human medicine.
Mathieu Giraudeau +29 more
wiley +1 more source