Results 181 to 190 of about 5,637 (202)

WWOX: Its genomics, partners, and functions

Journal of Cellular Biochemistry, 2009
AbstractThe WW domain‐containing oxidoreductase (WWOX) spans one of the most active common fragile sites (CFSs) involved in cancer, FRA16D. WWOX encodes a 46‐kDa protein that contains two N‐terminal WW domains and a central short‐chain dehydrogenase/reductase (SDR) domain.
Rami Aqeilan, Zaidoun Salah
exaly   +3 more sources

Pleiotropic tumor suppressor functions of WWOX antagonize metastasis [PDF]

Signal Transduction and Targeted Therapy, 2020
AbstractTumor progression and metastasis are the major causes of death among cancer associated mortality. Metastatic cells acquire features of migration and invasion and usually undergo epithelia-mesenchymal transition (EMT). Acquirement of these various hallmarks rely on different cellular pathways, including TGF-β and Wnt signaling.
Giovanni Nigita, Rosario Distefano, Abed Khalaileh   +2 more
exaly   +3 more sources

Practical clues for diagnosing WWOX encephalopathy

Epileptic Disorders, 2017
AbstractThe WW domain‐containing oxidoreductase gene is implicated in autosomal recessive disorders of the central nervous system, expressed either as spinocerebellar ataxia or as a severe form with early‐infantile epileptic encephalopathy. Here, we describe the electroclinical evolution of these disorders, adding new diagnostic clues based on a case ...
Oana, Tarta-Arsene, Diana, Barca, Dana, Craiu, Catrinel, Iliescu   +3 more
openaire   +2 more sources

PKA-mediated protein phosphorylation regulates ezrin–WWOX interaction

Biochemical and Biophysical Research Communications, 2006
The ezrin-radixin-moesin proteins provide a regulated linkage between membrane proteins and the cortical cytoskeleton, and also participate in signal-transduction pathways. Ezrin is localized to the apical membrane of parietal cells and couples the cAMP-dependent protein kinase activation cascade to the regulated HCl secretion in gastric parietal cells.
Changjiang, Jin, Ling, Ge, Xia, Ding, Yong, Chen, Hongling, Zhu, Tarsha, Ward, Fang, Wu, Xinwang, Cao, Qichen, Wang, Xuebiao, Yao   +9 more
openaire   +2 more sources

Tumor suppressor WWOX moderates the mitochondrial respiratory complex

Genes, Chromosomes and Cancer, 2015
Fragile site FRA16D exhibits DNA instability in cancer, resulting in diminished levels of protein from the WWOX gene that spans it. WWOX suppresses tumor growth by an undefined mechanism. WWOX participates in pathways involving aerobic metabolism and reactive oxygen species. WWOX comprises two WW domains as well as a short‐chain dehydrogenase/reductase
Choo, A., O'Keefe, L., Lee, C., Gregory, S., Shaukat, Z., Colella, A., Lee, K., Denton, D., Richards, R.   +8 more
openaire   +4 more sources

Loss of WWOX expression in human extrahepatic cholangiocarcinoma

Journal of Cancer Research and Clinical Oncology, 2008
WW domain-containing oxidoreductase (WWOX) is a tumor suppressor gene that maps to the common fragile site FRA16D on chromosome 16q23.3-24.1. To investigate the role of the WWOX gene in the development of extrahepatic cholangiocarcinoma (ECC), 30 tissue samples of ECC were examined.Loss of heterozygosity (LOH), real time reverse transcription PCR (RT ...
Mei, Wang, Jun, Gu, Yajie, Wang, Biao, Gong   +3 more
openaire   +2 more sources

WWOX activation by toosendanin suppresses hepatocellular carcinoma metastasis through JAK2/Stat3 and Wnt/β-catenin signaling

Cancer Letters, 2021
Rui Xu, Bingling Dai, Dongdong Zhang
exaly  

WWOX

2008
Kay Huebner, Rami Aqeilan
openaire   +1 more source

WWOX

2015
Morgan S. Schrock, Rami I. Aqeilan, Kay Huebner   +2 more
openaire   +1 more source

Molecular Functions of WWOX Potentially Involved in Cancer Development

Cells, 2021
Etienne Formstecher, François Lallemand
exaly