A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism [PDF]
Cell Communication and Signaling, 2019 Background Tumor suppressor WWOX physically binds p53 and TIAF1 and together induces apoptosis and tumor suppression. To understand the molecular action, here we investigated the formation of WWOX/TIAF1/p53 triad and its regulation of cancer cell ...
Chun-I Sze, Nan-Shan Chang
exaly +8 more sources
Self-aggregating TIAF1 in lung cancer progression [PDF]
Translational Respiratory Medicine, 2013 Abstract Recent studies have demonstrated that transforming growth factor beta (TGF-β1)-induced antiapoptotic factor (TIAF1) is able to form aggregates in the hippocampi of middle-aged normal individuals. The aggregating TIAF1 induces generation of amyloid beta (Aβ) for causing neurodegeneration.
Yu-An Chen, Nan-Shan Chang
exaly +8 more sources
TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death [PDF]
Cell Death and Disease, 2012 Self-aggregation of transforming growth factor β (TGF-β)1-induced antiapoptotic factor (TIAF1) is known in the nondemented human hippocampus, and the aggregating process may lead to generation of amyloid β (Aβ) for causing neurodegeneration. Here, we determined that overexpressed TIAF1 exhibits as aggregates together with Smad4 and Aβ in the cancer ...
Nan-Shan Chang
exaly +9 more sources
WWOX dysfunction induces sequential aggregation of TRAPPC6AΔ, TIAF1, tau and amyloid β, and causes apoptosis [PDF]
Cell Death Discovery, 2015 AbstractAggregated vesicle-trafficking protein isoform TRAPPC6AΔ (TPC6AΔ) has a critical role in causing caspase activation, tau aggregation and Aβgeneration in the brains of nondemented middle-aged humans, patients with Alzheimer’s disease (AD) and 3-week-oldWwoxgene knockout mice.
Nan-Shan Chang
exaly +6 more sources
TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease [PDF]
Cell Death and Disease, 2010 The role of a small transforming growth factor beta (TGF-β)-induced TIAF1 (TGF-β1-induced antiapoptotic factor) in the pathogenesis of Alzheimer's disease (AD) was investigated. TIAF1 physically interacts with mothers against DPP homolog 4 (Smad4), and blocks SMAD-dependent promoter activation when overexpressed.
Nan-Shan Chang
exaly +6 more sources
WWOX and Its Binding Proteins in Neurodegeneration [PDF]
Cells, 2021 WW domain-containing oxidoreductase (WWOX) is known as one of the risk factors for Alzheimer’s disease (AD), a neurodegenerative disease. WWOX binds Tau via its C-terminal SDR domain and interacts with Tau phosphorylating enzymes ERK, JNK, and GSK-3β ...
Kuan-Ting Lee +2 more
exaly +4 more sources
Identification of genes associated with histologic tumor grade of esophageal squamous cell carcinoma [PDF]
FEBS Open Bio, 2017 The present study aimed to identify the genes associated with the histologic tumor grade of patients with esophageal squamous cell carcinoma (ESCC) and to provide valuable information for the identification of potential diagnostic biomarkers in ESCC ...
Jiaqiang Xing, Cuicui Liu
doaj +3 more sources
Isolation, Expression Pattern, Polymorphism and Association Analysis of Porcine TIAF1 Gene [PDF]
Asian-Australasian Journal of Animal Sciences, 2009 TIAF1 is a TGF-β1-induced anti-apoptotic factor that plays a critical role in blocking TNF (tumor necrosis factor) cytotoxicity in mouse fibroblasts and participates in TGF-β-mediated growth regulation. In this study, we obtained the full-length cDNA sequence of the porcine TIAF1 gene. Real-time PCR further revealed that the TIAF1 gene was expressed at
Bo Zuo
exaly +3 more sources
WWOX Phosphorylation, Signaling, and Role in Neurodegeneration [PDF]
Frontiers in Neuroscience, 2018 Homozygous null mutation of tumor suppressor WWOX/Wwox gene leads to severe neural diseases, metabolic disorders and early death in the newborns of humans, mice and rats.
Chan-Chuan Liu, Yu-An Chen, Sheng-Nan Wu
exaly +4 more sources
Inhibition of Smad4 improves the cognitive function of APP/PS1 mice by targeting the level of c1qa [PDF]
Alzheimer's and DementiaAbstract Background Synaptic plasticity impairment plays a critical role in the pathogenesis of Alzheimer’s disease (AD), Smad4, a central intracellular signal transmission mediator of transmission of transforming growth factor‐β (TGF‐β) signaling, plays a pivotal role in many biological processes, including cell differentiation, migration, apoptosis ...
Ge J, Luo B.
exaly +3 more sources