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Isolation, Expression Pattern, Polymorphism and Association Analysis of Porcine TIAF1 Gene

Asian-Australasian Journal of Animal Sciences, 2009
TIAF1 is a TGF-β1-induced anti-apoptotic factor that plays a critical role in blocking TNF (tumor necrosis factor) cytotoxicity in mouse fibroblasts and participates in TGF-β-mediated growth regulation. In this study, we obtained the full-length cDNA sequence of the porcine TIAF1 gene. Real-time PCR further revealed that the TIAF1 gene was expressed at
C Y Deng, B Zuo, Y Z Xiong
exaly   +2 more sources

TRAPPC6AΔ, TIAF1 and SH3GLB2 are initiators for amyloid beta plaque formation and tau aggregation in vivo

FASEB Journal, 2018
Substantial evidence shows that tumor suppressor WW domain‐containing oxidoreductase, designated WWOX, FOR or WOX1, is involved in neurodegenerative diseases, neural disorders, cancer progression, and metabolic diseases. WWOX protects neurons from degeneration by binding tau and tau‐hyperphosphorylating enzymes GSK3β, ERK, and JNK1,
Chun-I Sze, Nan-Shan Chang, Jean-Yun Chang   +2 more
exaly   +2 more sources

Cloning and Characterization of a Novel Transforming Growth Factor-β1-Induced TIAF1 Protein That Inhibits Tumor Necrosis Factor Cytotoxicity

Biochemical and Biophysical Research Communications, 1998
To determine how TGF-beta1 protects L929 fibroblasts against TNF-alpha cytotoxicity, we report the isolation and characterization of a novel cDNA encoding a 12-kDa TGF-beta1-induced antiapoptotic factor, designated TIAF1. GFP-tagged TIAF1 protein is present mostly in perinuclear and nuclear locations.
Nicole Pratt, Nan-Shan Chang, N S Chang
exaly   +3 more sources

Functional antagonism between p53 and WWOX in vivo leads to protein aggregation in the brain

FASEB Journal, 2020
Chun-I Sze, Nan-Shan Chang, Sing-Ru Lin
exaly  

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Frontiers in Neuroscience, 2018
Yu-An Chen, Chun-I Sze
exaly  

TRIM 24 (tripartite motif-containing 24)

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Jl Huret
exaly  

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Frontiers in Oncology, 2013
Yu-An Chen, Chun-I Sze, Nan-Shan Chang
exaly  

A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism [PDF]

Cell Communication and Signaling, 2019
Background Tumor suppressor WWOX physically binds p53 and TIAF1 and together induces apoptosis and tumor suppression. To understand the molecular action, here we investigated the formation of WWOX/TIAF1/p53 triad and its regulation of cancer cell ...
Chun-I Sze, Nan-Shan Chang, Sing-Ru Lin
exaly   +7 more sources

Self-aggregating TIAF1 in lung cancer progression [PDF]

Translational Respiratory Medicine, 2013
Abstract Recent studies have demonstrated that transforming growth factor beta (TGF-β1)-induced antiapoptotic factor (TIAF1) is able to form aggregates in the hippocampi of middle-aged normal individuals. The aggregating TIAF1 induces generation of amyloid beta (Aβ) for causing neurodegeneration.
Yu-An Chen, Nan-Shan Chang, Li-Jin Hsu
exaly   +7 more sources

WWOX and Its Binding Proteins in Neurodegeneration [PDF]

Cells, 2021
WW domain-containing oxidoreductase (WWOX) is known as one of the risk factors for Alzheimer’s disease (AD), a neurodegenerative disease. WWOX binds Tau via its C-terminal SDR domain and interacts with Tau phosphorylating enzymes ERK, JNK, and GSK-3β ...
Shenq-Shyang Huang, Chun-I Sze, Nan-Shan Chang   +2 more
exaly   +4 more sources