Results 21 to 30 of about 218 (86)
, 2019 Figure S1. Wild type MEF cells migrate collectively, whereas Wwox knockout MEF cells migrate individually. Shown is the imaging of cell migration at 0 and 48 h by time-lapse microscopy. Also, see Additional file 2: Video S1 and Additional file 3: Video S2. The image is digitally enlarged from Fig. 2d. Figure S2.
Chou, Pei-Yi +5 more
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Zfra Overrides WWOX in Suppressing the Progression of Neurodegeneration. [PDF]
Int J Mol SciWe reported that a 31-amino-acid Zfra protein (zinc finger-like protein that regulates apoptosis) blocks neurodegeneration and cancer growth. Zfra binds WW domain-containing oxidoreductase (WWOX) to both N- and C-termini, which leads to accelerated WWOX ...
Chen YA +5 more
europepmc +2 more sources
TGF-β1 signals TIAF1 self-association, amyloid superinduction and apoptosis
Cytokine, 2009 Nan-Shan Chang
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Transcriptional characterization of human megakaryocyte polyploidization and lineage commitment
Journal of Thrombosis and Haemostasis, Volume 19, Issue 5, Page 1236-1249, May 2021., 2021 Abstract Background Megakaryocytes (MKs) originate from cells immuno‐phenotypically indistinguishable from hematopoietic stem cells (HSCs), bypassing intermediate progenitors. They mature within the adult bone marrow and release platelets into the circulation.
Fizzah A. Choudry +17 more
wiley +1 more source
BioMed Research International, Volume 2021, Issue 1, 2021., 2021 Objective. To investigate the genetic crosstalk mechanisms that link periodontitis and Alzheimer’s disease (AD). Background. Periodontitis, a common oral infectious disease, is associated with Alzheimer’s disease (AD) and considered a putative contributory factor to its progression.
Jieqi Jin +21 more
wiley +1 more source
TIAF1 is an essential partner for tumor suppressors p53- and WWOX-mediated apoptosis
The FASEB Journal, 2011 Tumor suppressors p53 and WOX1 (also named WWOX or FOR) participate in TGF‐β signaling, whereas the regulatory control is largely unknown. TIAF1 is a TGF‐β1‐induced factor, which regulates p53 activation, TNF cytotoxicity, and TGF‐β/Smad signaling.
Nan‐Shan Chang +2 more
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Survivin selective inhibitor YM155 induce apoptosis in SK-NEP-1 Wilms tumor cells
BMC Cancer, 2012 Background Survivin, a member of the family of inhibitor of apoptosis proteins, functions as a key regulator of mitosis and programmed cell death. YM155, a novel molecular targeted agent, suppresses survivin, which is overexpressed in many tumor types ...
Tao Yan-Fang +15 more
doaj +1 more source
Evidence for a role of p53, WWOX and TIAF1 as tumor suppression axis
The FASEB Journal, 2012 Tumor suppressor WWOX or WOX1 is frequently lost in many malignant tumors. Here we demonstrated that Wwox exon 1‐ deletion mouse embryonic fibroblasts (MEF Wwox−/−) migrated individually and faster than wild type Wwox+/+ cells. Normally, the wild type cells aligned together tightly and migrated collectively. WOX1 physically interacts with p53 and TIAF1
Pei-Yi Chou +5 more
openaire +1 more source