Results 21 to 30 of about 446 (111)
TIAF1 is an essential partner for tumor suppressors p53‐ and WWOX‐mediated apoptosis
The FASEB Journal, 2011 Tumor suppressors p53 and WOX1 (also named WWOX or FOR) participate in TGF‐β signaling, whereas the regulatory control is largely unknown. TIAF1 is a TGF‐β1‐induced factor, which regulates p53 activation, TNF cytotoxicity, and TGF‐β/Smad signaling.
Nan‐Shan Chang +2 more
+4 more sources
The FASEB Journal, 2012 TGF‐β‐induced factor TIAF1 forms aggregates in the hippocampus of normal individuals, and this may lead to the generation of amyloid beta (Aβ) and plaques as shown in Alzheimer's disease (AD). Here, we determined that TRAPPC6A gene deletion occurs at approximately a 3‐time higher incidence in AD than in normal controls. TRAPPC6A (TPC6A), a component of
Nan‐Shan Chang, Jean‐Yun Chang
openalex +2 more sources
The FASEB Journal, 2012 Self‐aggregation of TGF‐beta‐induced antiapoptotic factor (TIAF1) is known in the nondemented human hippocampus, and the aggregating process may lead to generation of amyloid beta (Abeta) for causing neurodegeneration. Here, we determined that solid tumors frequently overexpress TIAF1, which exhibits as aggregates together with Smad4 and Abeta in the ...
Nan‐Shan Chang
openalex +2 more sources
Evidence for a role of p53, WWOX and TIAF1 as tumor suppression axis
The FASEB Journal, 2012 Tumor suppressor WWOX or WOX1 is frequently lost in many malignant tumors. Here we demonstrated that Wwox exon 1‐ deletion mouse embryonic fibroblasts (MEF Wwox−/−) migrated individually and faster than wild type Wwox+/+ cells. Normally, the wild type cells aligned together tightly and migrated collectively. WOX1 physically interacts with p53 and TIAF1
Pei‐Yi Chou +5 more
openalex +2 more sources
Zfra Inhibits the TRAPPC6AΔ-Initiated Pathway of Neurodegeneration [PDF]
International Journal of Molecular Sciences, 2022 Yao-Hsiang Shih, Li-Jin Hsu, Yu-Min Kuo
exaly +2 more sources
TIAF1 self-aggregation precedes amyloid beta formation in vivo
, 2011 Nan‐Shan Chang
openalex +2 more sources
Zfra Overrides WWOX in Suppressing the Progression of Neurodegeneration [PDF]
International Journal of Molecular SciencesYu-An Chen, Chun-I Sze, Nan-Shan Chang
exaly +2 more sources
Receptor tyrosine kinase-dependent PI3K activation is an escape mechanism to vertical suppression of the EGFR/RAS/MAPK pathway in KRAS-mutated human colorectal cancer cell lines [PDF]
, 2019 BACKGROUND: Previous studies showed that the combination of an anti-Epidermal growth factor (EGFR) and a MEK-inhibitor is able to prevent the onset of resistance to anti-EGFR monoclonal antibodies in KRAS-wild type colorectal cancer (CRC), while the ...
Barra, Giusi +15 more
core +7 more sources