WWOX Controls Cell Survival, Immune Response and Disease Progression by pY33 to pS14 Transition to Alternate Signaling Partners [PDF]
Cells, 2022 Tumor suppressor WWOX inhibits cancer growth and retards Alzheimer’s disease (AD) progression. Supporting evidence shows that the more strongly WWOX binds intracellular protein partners, the weaker is cancer cell growth in vivo.
Shenq-Shyang Huang +2 more
exaly +4 more sources
Identification of genes associated with histologic tumor grade of esophageal squamous cell carcinoma [PDF]
FEBS Open Bio, 2017 The present study aimed to identify the genes associated with the histologic tumor grade of patients with esophageal squamous cell carcinoma (ESCC) and to provide valuable information for the identification of potential diagnostic biomarkers in ESCC ...
Jiaqiang Xing, Cuicui Liu
doaj +3 more sources
TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease [PDF]
Cell Death and Disease, 2010 The role of a small transforming growth factor beta (TGF-β)-induced TIAF1 (TGF-β1-induced antiapoptotic factor) in the pathogenesis of Alzheimer's disease (AD) was investigated. TIAF1 physically interacts with mothers against DPP homolog 4 (Smad4), and blocks SMAD-dependent promoter activation when overexpressed.
Yu-Min Kuo, Q Hong
exaly +6 more sources
Assessing current therapeutic approaches to decode potential resistance mechanisms in glioblastomas [PDF]
Frontiers in Oncology, 2013 Unique astrocytic cell infiltrating growth and glial tumor growth in the confined skull make human glioblastoma multiforme (GBM) one of the most difficult cancers to treat in modern medicine.
Chun-I eSze +5 more
doaj +4 more sources
Inhibition of Smad4 improves the cognitive function of APP/PS1 mice by targeting the level of c1qa [PDF]
Alzheimer's and DementiaAbstract Background Synaptic plasticity impairment plays a critical role in the pathogenesis of Alzheimer’s disease (AD), Smad4, a central intracellular signal transmission mediator of transmission of transforming growth factor‐β (TGF‐β) signaling, plays a pivotal role in many biological processes, including cell differentiation, migration, apoptosis ...
Benyan Luo
exaly +3 more sources
Zfra Inhibits the TRAPPC6AΔ-Initiated Pathway of Neurodegeneration [PDF]
International Journal of Molecular Sciences, 2022 When WWOX is downregulated in middle age, aggregation of a protein cascade, including TRAPPC6AΔ (TPC6AΔ), TIAF1, and SH3GLB2, may start to occur, and the event lasts more than 30 years, which results in amyloid precursor protein (APP ...
Yao-Hsiang Shih +2 more
exaly +3 more sources
WWOX dysfunction induces sequential aggregation of TRAPPC6AΔ, TIAF1, tau and amyloid β, and causes apoptosis [PDF]
Cell Death Discovery, 2015 AbstractAggregated vesicle-trafficking protein isoform TRAPPC6AΔ (TPC6AΔ) has a critical role in causing caspase activation, tau aggregation and Aβgeneration in the brains of nondemented middle-aged humans, patients with Alzheimer’s disease (AD) and 3-week-oldWwoxgene knockout mice.
Chang JY, Chang NS.
exaly +5 more sources
TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death [PDF]
Cell Death and Disease, 2012 Self-aggregation of transforming growth factor β (TGF-β)1-induced antiapoptotic factor (TIAF1) is known in the nondemented human hippocampus, and the aggregating process may lead to generation of amyloid β (Aβ) for causing neurodegeneration. Here, we determined that overexpressed TIAF1 exhibits as aggregates together with Smad4 and Aβ in the cancer ...
S-J Chen
exaly +4 more sources
WWOX Phosphorylation, Signaling, and Role in Neurodegeneration [PDF]
Frontiers in Neuroscience, 2018 Homozygous null mutation of tumor suppressor WWOX/Wwox gene leads to severe neural diseases, metabolic disorders and early death in the newborns of humans, mice and rats.
Chan-Chuan Liu +14 more
doaj +2 more sources
Abstract 3974: TIAF1 blocks p53 suppression of SMAD promoter activation
Cancer Research, 2010 Abstract p53 participates in the TGF-β signaling. How p53 regulates SMAD gene transcription is largely unknown. TIAF1 is a TGF-β1-induced factor and a downstream effector of the TGF-β signaling. TIAF1 is known to control nuclear localization of Ser15-phosphorylated p53.
Nan-Shan Chang +3 more
openaire +2 more sources