Results 11 to 20 of about 446 (111)

TIAF1 self‐aggregation is essential for Aβ plaque formation in the human hippocampus

FASEB Journal, 2010
Role of TIAF1 in the TGF‐β pathway leading to the pathogenesis of Alzheimer's disease (AD) was investigated. We determined that TIAF1 bound Smad4 and blocked its‐regulated promoter activation. TGF‐β1 induced self‐aggregation of transiently overexpressed TIAF1 in a type II TGF‐β receptor (TβRII)‐independent ...
Nan-Shan Chang
exaly   +3 more sources

Assessing Current Therapeutic Approaches to Decode Potential Resistance Mechanisms in Glioblastomas [PDF]

Frontiers in Oncology, 2013
Unique astrocytic cell infiltrating growth and glial tumor growth in the confined skull make human glioblastoma multiforme (GBM) one of the most difficult cancers to treat in modern medicine.
Chun-I Sze, Nan-Shan Chang
exaly   +4 more sources

TRAPPC6AΔ, TIAF1 and SH3GLB2 are initiators for amyloid beta plaque formation and tau aggregation in vivo

FASEB Journal, 2018
Substantial evidence shows that tumor suppressor WW domain‐containing oxidoreductase, designated WWOX, FOR or WOX1, is involved in neurodegenerative diseases, neural disorders, cancer progression, and metabolic diseases. WWOX protects neurons from degeneration by binding tau and tau‐hyperphosphorylating enzymes GSK3β, ERK, and JNK1,
Nan-Shan Chang
exaly   +3 more sources

WWOX Controls Cell Survival, Immune Response and Disease Progression by pY33 to pS14 Transition to Alternate Signaling Partners [PDF]

Cells, 2022
Tumor suppressor WWOX inhibits cancer growth and retards Alzheimer’s disease (AD) progression. Supporting evidence shows that the more strongly WWOX binds intracellular protein partners, the weaker is cancer cell growth in vivo.
Tsung-Yun Liu, Ganesan Nagarajan, Ming-Fu Chiang, Shenq-Shyang Huang, Tzu-Chia Lin, Yu-An Chen, Chun-I Sze, Nan-Shan Chang   +7 more
doaj   +2 more sources

Transcriptional characterization of human megakaryocyte polyploidization and lineage commitment [PDF]

Journal of Thrombosis and Haemostasis, Volume 19, Issue 5, Page 1236-1249, May 2021., 2021
Abstract Background Megakaryocytes (MKs) originate from cells immuno‐phenotypically indistinguishable from hematopoietic stem cells (HSCs), bypassing intermediate progenitors. They mature within the adult bone marrow and release platelets into the circulation.
Fizzah A. Choudry, Frederik O. Bagger, Iain C. Macaulay, Samantha Farrow, Frances Burden, Carly Kempster, Harriet McKinney, Lars R. Olsen, Ni Huang, Kate Downes, Thierry Voet, Rakesh Uppal, John F. Martin, Anthony Mathur, Willem H. Ouwehand, Elisa Laurenti, Sarah A. Teichmann, Mattia Frontini   +17 more
wiley   +3 more sources

Mitochondria inter-organelle relationships in cancer protein aggregation. [PDF]

Front Cell Dev Biol, 2022
Mitochondria are physically associated with other organelles, such as ER and lysosomes, forming a complex network that is crucial for cell homeostasis regulation.
Genovese I, Fornetti E, Ruocco G.
europepmc   +3 more sources

Comparability of Microarray Data between Amplified and Non Amplified RNA in Colorectal Carcinoma [PDF]

BioMed Research International, Volume 2009, Issue 1, 2009., 2009
Microarray analysis reaches increasing popularity during the investigation of prognostic gene clusters in oncology. The standardisation of technical procedures will be essential to compare various datasets produced by different research groups. In several projects the amount of available tissue is limited.
Roland S. Croner, Berthold Lausen, Vera Schellerer, Isabel Zeittraeger, Axel Wein, Claus Schildberg, Thomas Papadopoulos, Arno Dimmler, Eckhart G. Hahn, Werner Hohenberger, Wolfgang M. Brueckl, Yataro Daigo   +11 more
wiley   +5 more sources

GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors. [PDF]

Am J Psychiatry, 2023
OBJECTIVE: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA).
Docherty AR, Mullins N, Ashley-Koch AE, Qin X, Coleman JRI, Shabalin A, Kang J, Murnyak B, Wendt F, Adams M, Campos AI, DiBlasi E, Fullerton JM, Kranzler HR, Bakian AV, Monson ET, Rentería ME, Walss-Bass C, Andreassen OA, Behera C, Bulik CM, Edenberg HJ, Kessler RC, Mann JJ, Nurnberger JI, Pistis G, Streit F, Ursano RJ, Polimanti R, Dennis M, Garrett M, Hair L, Harvey P, Hauser ER, Hauser MA, Huffman J, Jacobson D, Madduri R, McMahon B, Oslin DW, Trafton J, Awasthi S, Berrettini WH, Bohus M, Chang X, Chen HC, Chen WJ, Christensen ED, Crow S, Duriez P, Edwards AC, Fernández-Aranda F, Galfalvy H, Gandal M, Gorwood P, Guo Y, Hafferty JD, Hakonarson H, Halmi KA, Hishimoto A, Jain S, Jamain S, Jiménez-Murcia S, Johnson C, Kaplan AS, Kaye WH, Keel PK, Kennedy JL, Kim M, Klump KL, Levey DF, Li D, Liao SC, Lieb K, Lilenfeld L, Marshall CR, Mitchell JE, Okazaki S, Otsuka I, Pinto D, Powers A, Ramoz N, Ripke S, Roepke S, Rozanov V, Scherer SW, Schmahl C, Sokolowski M, Starnawska A, Strober M, Su MH, Thornton LM, Treasure J, Ware EB, Watson HJ, Witt SH, Woodside DB, Yilmaz Z, Zillich L, Adolfsson R, Agartz I, Alda M, Alfredsson L, Appadurai V, Artigas MS, Van der Auwera S, Azevedo MH, Bass N, Bau CHD, Baune BT, Bellivier F, Berger K, Biernacka JM, Bigdeli TB, Binder EB, Boehnke M, Boks MP, Braff DL, Bryant R, Budde M, Byrne EM, Cahn W, Castelao E, Cervilla JA, Chaumette B, Corvin A, Craddock N, Djurovic S, Foo JC, Forstner AJ, Frye M, Gatt JM, Giegling I, Grabe HJ, Green MJ, Grevet EH, Grigoroiu-Serbanescu M, Gutierrez B, Guzman-Parra J, Hamshere ML, Hartmann AM, Hauser J, Heilmann-Heimbach S, Hoffmann P, Ising M, Jones I, Jones LA, Jonsson L, Kahn RS, Kelsoe JR, Kendler KS, Kloiber S, Koenen KC, Kogevinas M, Krebs MO, Landén M, Leboyer M, Lee PH, Levinson DF, Liao C, Lissowska J, Mayoral F, McElroy SL, McGrath P, McGuffin P, McQuillin A, Mehta D, Melle I, Mitchell PB, Molina E, Morken G, Nievergelt C, Nöthen MM, O'Donovan MC, Ophoff RA, Owen MJ, Pato C, Pato MT, Penninx BWJH, Potash JB, Power RA, Preisig M, Quested D, Ramos-Quiroga JA, Reif A, Ribasés M, Richarte V, Rietschel M, Rivera M, Roberts A, Roberts G, Rouleau GA, Rovaris DL, Sanders AR, Schofield PR, Schulze TG, Scott LJ, Serretti A, Shi J, Sirignano L, Sklar P, Smeland OB, Smoller JW, Sonuga-Barke EJS, Trzaskowski M, Tsuang MT, Turecki G, Vilar-Ribó L, Vincent JB, Völzke H, Walters JTR, Weickert CS, Weickert TW, Weissman MM, Williams LM, Wray NR, Zai CC, Agerbo E, Børglum AD, Breen G, Demontis D, Erlangsen A, Gelernter J, Glatt SJ, Hougaard DM, Hwu HG, Kuo PH, Lewis CM, Li QS, Liu CM, Martin NG, McIntosh AM, Medland SE, Mors O, Nordentoft M, Olsen CM, Porteous D, Smith DJ, Stahl EA, Stein MB, Wasserman D, Werge T, Whiteman DC, Willour V, VA Million Veteran Program (MVP), MVP Suicide Exemplar Workgroup, Suicide Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Eating Disorder Working Group of the Psychiatric Genomics Consortium, German Borderline Genomics Consortium, Coon H, Beckham JC, Kimbrel NA, Ruderfer DM.   +255 more
europepmc   +8 more sources

Intracellular TIAF1 self‐association induces apoptosis

The FASEB Journal, 2009
TIAF1 is a small TGF‐beta1‐induced factor, which supports fibroblast growth, T helper cell activation and effect on allograft organ rejection, and probably induces regulator TREG cell differentiation. However, overexpressed TIAF1 induces apoptosis in monocytic and epithelial cells and non‐fibroblasts.
Nan‐Shan Chang
openalex   +2 more sources

TIAF1 physically heterodimerizes with WOX1 in the mitochondria: a role in apoptosis

The FASEB Journal, 2008
Overexpressed TIAF1 (TGF‐beta1‐induced antiapoptotic factor) promotes the growth of fibroblasts, but induces apoptosis in monocytic and non‐fibroblast cells. Functional property of TIAF1 in regulating cell growth and death is largely unknown. Here, we show that knockdown of endogenous TIAF1 by siRNA prevented cell growth inhibition and apoptosis by ...
Nan‐Shan Chang
openalex   +2 more sources