B-cell receptor-driven MALT1 activity regulates MYC signaling in mantle cell lymphoma. [PDF]
, 2017 Mantle cell lymphoma (MCL) is a mature B-cell lymphoma characterized by poor clinical outcome. Recent studies revealed the importance of B-cell receptor (BCR) signaling in maintaining MCL survival.
Anagnostopoulos, I. +29 more
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Mosaic TP53 Mutation on Tumour Development in Pigs : A Case Study [PDF]
, 2023 Pigs rarely develop cancer; however, tumour protein p53 (TP53)-modified pigs may have an increased incidence of cancer. In this study, two pigs with mosaic mutations induced by gene editing were compared to determine the role of the wild-type TP53 ...
1349 +32 more
core
Delineating the Genetic Component of Gene Expression in Major Depression [PDF]
, 2020 Background: Major depression (MD) is determined by a multitude of factors including genetic risk variants that regulate gene expression. We examined the genetic component of gene expression in MD by performing a transcriptome-wide association study (TWAS)
Dall'Aglio, L. (Lorenza) +2 more
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Gene expression studies in T helper cell subsets:implications for immunomodulation in transplantation [PDF]
, 2005 T helper (Th) cellen spelen een belangrijke rol bij het genereren van een effectieve immuunrespons tegen pathogenen als bacteriën en virussen. Oorspronkelijk werken T helper cellen op basis van het cytokineprofiel onderverdeeld in twee subpopulaties ...
Leij, Judith van der
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Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast [PDF]
, 2014 Micropapillary carcinoma ( MPC ) is a rare histological special type of breast cancer, characterized by an aggressive clinical behaviour and a pattern of copy number aberrations ( CNAs ) distinct from that of grade‐ and oestrogen receptor ( ER )‐matched ...
A'hern, Roger +26 more
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Integrin α\u3csub\u3ev\u3c/sub\u3eβ\u3csub\u3e8\u3c/sub\u3e Adopts a High Affinity State for Soluble Ligands Under Physiological Conditions [PDF]
, 2017 © 2016 Wiley Periodicals, Inc. It has been proposed that integrins adopt a low affinity conformation under physiological conditions. Integrin can either be activated through cytoplasm or by binding of cations such as Mn2+ to the head domain.
Hu, Ping, Luo, Bing Hao
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The FASEB Journal, Volume 38, Issue 10, 31 May 2024.This study depicts versatile functions of MYO18A isoforms in transcellular and cytoskeletal signaling processes that modulate epithelial barrier integrity, cellular migration and adhesion, viral infection, endosomal trafficking, macrophage functions, structural development of heart and muscle, and integrity of the alveolar capillary barrier.
William DeKryger, Zissis C. Chroneos
wiley +1 more source
Transcriptomes reflect the phenotypes of undifferentiated, granulocyte and macrophage forms of HL-60/S4 cells [PDF]
, 2017 Author Posting. © The Author(s), 2017. This is the author's version of the work. It is posted here by permission of Taylor & Francis for personal use, not for redistribution.
Jauch, Anna +4 more
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HORMESIS, CELL DEATH, AND REGENERATIVE MEDICINE FOR NEURODEGENERATIVE DISEASES [PDF]
, 2012 Although the adult human brain has a small number of neural stem cells, they are insufficient to repair the damaged brain to achieve significant functional recovery for neurodegenerative diseases and stroke.
Wang, Guanghu
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The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons [PDF]
, 2018 Degrons are minimal elements that mediate the interaction of proteins with degradation machineries to promote proteolysis. Despite their central role in proteostasis, the number of known degrons remains small and a facile technology to characterize them ...
Elledge, Stephen J +5 more
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