Results 31 to 40 of about 218 (86)
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 3, Issue 2, Page 189-204, June 2017., 2017 Introduction Zinc finger‐like protein that regulates apoptosis (Zfra) is a naturally occurring 31‐amino‐acid protein. Synthetic peptides Zfra1–31 and Zfra4–10 are known to effectively block the growth of many types of cancer cells. Methods Ten‐month‐old triple‐transgenic (3×Tg) mice for Alzheimer's disease (AD) received synthetic Zfra peptides via tail
Ming‐Hui Lee +7 more
wiley +1 more source
Signatures of human regulatory T cells: an encounter with old friends and new players. [PDF]
, 2006 BACKGROUND: Naturally occurring CD4+ CD25+ regulatory T cells (TReg) are involved in the control of autoimmune diseases, transplantation tolerance, and anti-tumor immunity.
Jan Buer +21 more
core +1 more source
Comparability of Microarray Data between Amplified and Non Amplified RNA in Colorectal Carcinoma
BioMed Research International, Volume 2009, Issue 1, 2009., 2009 Microarray analysis reaches increasing popularity during the investigation of prognostic gene clusters in oncology. The standardisation of technical procedures will be essential to compare various datasets produced by different research groups. In several projects the amount of available tissue is limited.
Roland S. Croner +11 more
wiley +1 more source
Molekulare Charakterisierung humaner regulatorischer T-Zellen in Gesundheit und Krankheit [PDF]
, 2007 Naturally occurring CD4+CD25+ regulatory T cells (TReg) play a pivotal role in the maintenance of peripheral tolerance. TReg are involved in the control of autoimmunity, transplantation tolerance and anti-tumor responses.
Pförtner, Susanne
core +1 more source
Table_1_WWOX Phosphorylation, Signaling, and Role in Neurodegeneration.XLSX
, 2018 Homozygous null mutation of tumor suppressor WWOX/Wwox gene leads to severe neural diseases, metabolic disorders and early death in the newborns of humans, mice and rats.
I.-Ting Lee (5633123) +9 more
core +1 more source
Intracellular TIAF1 self‐association induces apoptosis
The FASEB Journal, 2009 TIAF1 is a small TGF‐beta1‐induced factor, which supports fibroblast growth, T helper cell activation and effect on allograft organ rejection, and probably induces regulator TREG cell differentiation. However, overexpressed TIAF1 induces apoptosis in monocytic and epithelial cells and non‐fibroblasts.
openaire +1 more source
The FASEB Journal, Volume 38, Issue 10, 31 May 2024.This study depicts versatile functions of MYO18A isoforms in transcellular and cytoskeletal signaling processes that modulate epithelial barrier integrity, cellular migration and adhesion, viral infection, endosomal trafficking, macrophage functions, structural development of heart and muscle, and integrity of the alveolar capillary barrier.
William DeKryger, Zissis C. Chroneos
wiley +1 more source
TIAF1 physically heterodimerizes with WOX1 in the mitochondria: a role in apoptosis
The FASEB Journal, 2008 Overexpressed TIAF1 (TGF‐beta1‐induced antiapoptotic factor) promotes the growth of fibroblasts, but induces apoptosis in monocytic and non‐fibroblast cells. Functional property of TIAF1 in regulating cell growth and death is largely unknown. Here, we show that knockdown of endogenous TIAF1 by siRNA prevented cell growth inhibition and apoptosis by ...
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The FASEB Journal, 2012 TGF‐β‐induced factor TIAF1 forms aggregates in the hippocampus of normal individuals, and this may lead to the generation of amyloid beta (Aβ) and plaques as shown in Alzheimer's disease (AD). Here, we determined that TRAPPC6A gene deletion occurs at approximately a 3‐time higher incidence in AD than in normal controls. TRAPPC6A (TPC6A), a component of
Nan-Shan Chang, Jean-Yun Chang
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, 2009 Hirschsprung's disease (HSCR), a congenital complex disorder of intestinal innervation, is often associated with other inherited syndromes. Identifying genes involved in syndromic HSCR cases will not only help understanding the specific underlying ...
Paola Griseri +19 more
core +1 more source