Results 31 to 40 of about 446 (111)
BioMed Research International, Volume 2021, Issue 1, 2021., 2021 Objective. To investigate the genetic crosstalk mechanisms that link periodontitis and Alzheimer’s disease (AD). Background. Periodontitis, a common oral infectious disease, is associated with Alzheimer’s disease (AD) and considered a putative contributory factor to its progression.
Jieqi Jin +21 more
wiley +1 more source
Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders, and known risk factors [PDF]
, 2022 Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden.
Bau, Claiton Henrique Dotto +3 more
core +10 more sources
Survivin selective inhibitor YM155 induce apoptosis in SK-NEP-1 Wilms tumor cells
BMC Cancer, 2012 Background Survivin, a member of the family of inhibitor of apoptosis proteins, functions as a key regulator of mitosis and programmed cell death. YM155, a novel molecular targeted agent, suppresses survivin, which is overexpressed in many tumor types ...
Tao Yan-Fang +15 more
doaj +1 more source
C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1 [PDF]
, 2012 Alternative pre-mRNA processing is a central element of eukaryotic gene regulation. The cell frequently alters the use of alternative exons in response to physiological stimuli.
Akhmedov +58 more
core +4 more sources
Dynamic expression of genes associated with schizophrenia and bipolar disorder across development [PDF]
, 2019 Common genetic variation contributes a substantial proportion of risk for both schizophrenia and bipolar disorder. Furthermore, there is evidence of significant, but not complete, overlap in genetic risk between the two disorders.
Clifton, Nicholas E. +10 more
core +3 more sources
Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease [PDF]
, 2022 Plasma biomarkers for Alzheimer's disease-related pathologies have undergone rapid developments during the past few years, and there are now well-validated blood tests for amyloid and tau pathology, as well as neurodegeneration and astrocytic activation.
Bellou, Eftychia +13 more
core +4 more sources
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 3, Issue 2, Page 189-204, June 2017., 2017 Introduction Zinc finger‐like protein that regulates apoptosis (Zfra) is a naturally occurring 31‐amino‐acid protein. Synthetic peptides Zfra1–31 and Zfra4–10 are known to effectively block the growth of many types of cancer cells. Methods Ten‐month‐old triple‐transgenic (3×Tg) mice for Alzheimer's disease (AD) received synthetic Zfra peptides via tail
Ming‐Hui Lee +7 more
wiley +1 more source
Cell death pathology: Perspective for human diseases [PDF]
, 2011 Apoptosis, a genetically regulated form of cell death with distinct biochemical and morphological features, plays a relevant physiological and pathological role in the organism, being pivotal in the maintenance of tissue development and homeostasis in ...
Agostini, Massimiliano +2 more
core +1 more source
Exome-wide association study of pancreatic cancer risk [PDF]
, 2018 We conducted a case-control exome-wide association study to discover germline variants in coding regions that affect risk for pancreatic cancer, combining data from 5 studies. We analyzed exome and genome sequencing data from 437 patients with pancreatic
Biankin, Andrew +18 more
core +1 more source
Moyamoya disease-specific extracellular vesicle-derived microRNAs in the cerebrospinal fluid revealed by comprehensive expression analysis through microRNA sequencing [PDF]
, 2023 Purpose: To examine the specific changes that occur in the expression levels of extracellular vesicle-derived microRNAs (miRNAs) in intracranial cerebrospinal fluid (CSF) in moyamoya disease. Methods: Patients with arteriosclerotic cerebral ischemia were
Araki, Yoshio +8 more
core +1 more source