X chromosome inactivation, X-linked disorders, and cancer [PDF]
Frontiers in GeneticsX chromosome inactivation is an essential process that compensates for gene dosage differences between men and women. During early embryogenesis, one of the two X chromosomes in females is randomly selected for transcriptional silencing, inactivating ...
Consuelo Salas-Labadía +6 more
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X-Linked EGFP Reporter as a Tool to Examine X-Chromosome Inactivation in Mouse Embryos and Embryonic Fibroblasts [PDF]
BiomoleculesThis study aimed to establish a model for investigating X chromosome inactivation using transgenic mouse strains expressing green fluorescent protein (GFP).
Martin Urbán +5 more
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X Chromosome Inactivation during Drosophila Spermatogenesis [PDF]
PLoS Biology, 2007 Genes with male- and testis-enriched expression are under-represented on the Drosophila melanogaster X chromosome. There is also an excess of retrotransposed genes, many of which are expressed in testis, that have "escaped" the X chromosome and moved to ...
John Baines, John Parsch
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Population variability in X-chromosome inactivation across 10 mammalian species [PDF]
Nature CommunicationsOne of the two X-chromosomes in female mammals is epigenetically silenced in embryonic stem cells by X-chromosome inactivation. This creates a mosaic of cells expressing either the maternal or the paternal X allele.
Jonathan M. Werner +2 more
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A Comparative Analysis of Mouse Imprinted and Random X-Chromosome Inactivation [PDF]
EpigenomesThe mammalian sexes are distinguished by the X and Y chromosomes. Whereas males harbor one X and one Y chromosome, females harbor two X chromosomes.
Rebecca M. Malcore, Sundeep Kalantry
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IndiSPENsable for X Chromosome Inactivation and Gene Silencing [PDF]
Epigenomes, 2023 For about 30 years, SPEN has been the subject of research in many different fields due to its variety of functions and its conservation throughout a wide spectrum of species, like worms, arthropods, and vertebrates.
Corinne Kaufmann, Anton Wutz
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An investigation of a hemophilia A female with heterozygous intron 22 inversion and skewed X chromosome inactivation [PDF]
Frontiers in GeneticsObjectivesHemophilia A (HA) is an X-linked recessive inherited bleeding disorder that typically affects men. Women are usually asymptomatic carriers, and rarely presenting with severe or moderately severe phenotype.
Xiaoyan Tan +7 more
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Selection of X-chromosome Inactivation Model
Cancer Informatics, 2017 To address the complexity of the X-chromosome inactivation (XCI) process, we previously developed a unified approach for the association test for X-chromosomal single-nucleotide polymorphisms (SNPs) and the disease of interest, accounting for different ...
Sanjay Shete, Rajesh Talluri
exaly +2 more sources
Inexpensive protocol for single-cell X-chromosome inactivation analysis: Xist expression and H3K27me3 staining [PDF]
Письма в Вавиловский журнал генетики и селекции, 2022 The X-chromosome status is an important marker of mammalian cell embryonic differentiation. Both female X-chromosomes are transcriptionally active (Xa) at the blastocyst stage, then one of the X-chromosomes undergoes random inactivation (Xi).
Pristyazhnyuk I.E. +2 more
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Elastic dosage compensation by X-chromosome upregulation
Nature Communications, 2022 The concerted dynamics of X-chromosome upregulation and X-chromosome inactivation, which collectively balance X-chromosome expression, are not well understood.
Antonio Lentini +8 more
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