Results 1 to 10 of about 16,717 (221)

Xist Exon 7 Contributes to the Stable Localization of Xist RNA on the Inactive X-Chromosome. [PDF]

PLoS Genetics, 2015
To equalize X-linked gene dosage between the sexes in mammalian females, Xist RNA inactivates one of the two X-chromosomes. Here, we report the crucial function of Xist exon 7 in X-inactivation.
Norishige Yamada, Yuko Hasegawa, Minghui Yue, Tomofumi Hamada, Shinichi Nakagawa, Yuya Ogawa   +5 more
doaj   +5 more sources

Xist regulation and function eXplored [PDF]

Human Genetics, 2011
X chromosome inactivation (XCI) is a process in mammals that ensures equal transcript levels between males and females by genetic inactivation of one of the two X chromosomes in females. Central to XCI is the long non-coding RNA Xist, which is highly and specifically expressed from the inactive X chromosome.
Joost Gribnau
exaly   +6 more sources

XIST in Brain Cancer [PDF]

Clinica Chimica Acta, 2022
Long non-coding RNAs (lncRNAs) make up the majority of the human genome. They are a group of small RNA molecules that do not code for any proteins but play a primary role in regulating a variety of physiological and pathological processes. X-inactive specific transcript (XIST), one of the first lncRNAs to be discovered, is chiefly responsible for X ...
Eldesouki, Salma, Samara, Kamel A, Qadri, Rama, Obaideen, Anas A, Otour, Ahmad H, Habbal, Omar, Ahmed, Samrein   +6 more
openaire   +4 more sources

Xist and the order of silencing [PDF]

EMBO Reports, 2007
X inactivation is the mechanism by which mammals adjust the genetic imbalance that arises from the different numbers of gene-rich X-chromosomes between the sexes. The dosage difference between XX females and XY males is functionally equalized by silencing one of the two X chromosomes in females.
Martin Leeb, Anton Wütz
exaly   +3 more sources

Single-cell transcriptomic analysis reveals subtle fluctuations of oocyte cryopreservation on mouse early embryo development. [PDF]

Clin Transl Med
Mature oocytes were subjected to cryopreservation followed by intracytoplasmic sperm injection (ICSI). Embryos at multiple developmental stages were collected, dissociated into single cells and processed for single‐cell library construction and bioinformatics analysis.
Ren Y, Zhang Q, Xu F, Li Y, Liao T, Zhao M, Yan Z, Zhu X, Wang N, Yuan P, Smith GD, Qiao J, Yan J, Yan L, He Q.   +14 more
europepmc   +2 more sources

<i>XIST</i> Is a Key Modulator Associated With the Adhesome Network. [PDF]

FASEB Bioadv
CRISPRi‐mediated knockdown of XIST in OVCAR3 ovarian cancer cells alters adhesome gene expression, supporting a functional connection between XIST and cell adhesion programs. Building on this finding, transcriptomic analyses of GTEx and TCGA datasets reveal that XIST is strongly coordinated with the adhesome network across normal tissues, whereas this ...
Chen D, Origer N, Sun S, Downing TL.
europepmc   +2 more sources

SETDB1 and HUSH modulate Xist RNA levels during establishment of X chromosome inactivation [PDF]

Nature Communications
The non-coding RNA Xist mediates X chromosome inactivation (XCI) in mammals, functioning in cis to direct heterochromatin formation over a single X chromosome in cells of early female embryos.
Mafalda Almeida, Guifeng Wei, Adam D. Cawte, Tatyana B. Nesterova, Neil Brockdorff   +4 more
doaj   +2 more sources

LncRNA XIST modulates HIF‐1A/AXL signaling pathway by inhibiting miR‐93‐5p in colorectal cancer

Molecular Genetics & Genomic Medicine, 2020
Background Long noncoding RNA (LncRNA) XIST is one of the genes that exists in different types of cancers. Earlier researches showed that XIST can advance the progression of colorectal cancer.
Qin-Li Sun
exaly   +2 more sources

Long noncoding RNA X-inactive-specific transcript promotes hepatic fibrosis by suppressing ferroptosis in hepatic stellate cells via the miR-663a/GPX4 axis [PDF]

Frontiers in Physiology
AimHepatic fibrosis (HF) is a critical pathological stage in the progression of chronic liver diseases, where hepatic stellate cell (HSC) activation is a key event.
Jing Dai, Guo-Hui Zhong, Jun-Xing Yang, Xiao-Yu Tan, Dong Dai, Ming-Yi Li   +5 more
doaj   +2 more sources

The B-side of Xist [PDF]

F1000Research, 2020
Female mammals express the long noncoding X inactivation-specific transcript (Xist) RNA to initiate X chromosome inactivation (XCI) that eventually results in the formation of the Barr body. Xist encompasses half a dozen repeated sequence stretches containing motifs for RNA-binding proteins that recruit effector complexes with functions for silencing ...
Asun Monfort, Anton Wutz
openaire   +4 more sources