Results 31 to 40 of about 16,717 (221)

A regulatory potential of the Xist gene promoter in vole M. rossiaemeridionalis. [PDF]

PLoS ONE, 2012
X chromosome inactivation takes place in the early development of female mammals and depends on the Xist gene expression. The mechanisms of Xist expression regulation have not been well understood so far. In this work, we compared Xist promoter region of
Konstantin E Orishchenko, Sophia V Pavlova, Eugeny A Elisaphenko, Vladimir V Sherstyuk, Alexander V Prinz, Alexander I Shevchenko, Elena V Dementyeva, Suren M Zakian   +7 more
doaj   +1 more source

Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation

eLife, 2020
The Xist lncRNA mediates X chromosome inactivation (XCI). Here we show that Spen, an Xist-binding repressor protein essential for XCI , binds to ancient retroviral RNA, performing a surveillance role to recruit chromatin silencing machinery to these ...
Ava C Carter, Jin Xu, Meagan Y Nakamoto, Yuning Wei, Brian J Zarnegar, Quanming Shi, James P Broughton, Ryan C Ransom, Ankit Salhotra, Surya D Nagaraja, Rui Li, Diana R Dou, Kathryn E Yost, Seung-Woo Cho, Anil Mistry, Michael T Longaker, Paul A Khavari, Robert T Batey, Deborah S Wuttke, Howard Y Chang   +19 more
doaj   +1 more source

Inhibition of long non-coding RNA XIST upregulates microRNA-149-3p to repress ovarian cancer cell progression

Cell Death and Disease, 2021
Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play critical roles in human diseases. We aimed to clarify the role of lncRNA X-inactive specific transcript (XIST)/miR-149-3p/forkhead box P3 (FOXP3) axis in ovarian cancer (OC) cell growth.
Rong Jiang, Hongyu Zhang, Jinhua Zhou, Juan Wang, Yuejuan Xu, He Zhang, Yanzheng Gu, Fengqing Fu, Yu Shen, Guangbo Zhang, Lanlan Feng, Xueguang Zhang, Youguo Chen, Fangrong Shen   +13 more
doaj   +1 more source

Extinction of Xist Improves Cloning [PDF]

Cell Stem Cell, 2010
Mammalian cloning by somatic cell nuclear transfer is a notoriously inefficient process with a low birth rate. Recently in Science, Inoue et al. (2010) report that somatic cell nuclear transfer fails to regulate Xist expression from the X chromosome.
Tonge, Peter Dennis, Nagy, Andras
openaire   +2 more sources

LncRNA XIST promoted the stability of TLR9 mRNA in a FUS-dependent manner to facilitate aerobic glycolysis and proliferation in Th17/CD4+T cells

Linchuang shenzangbing zazhi, 2022
ObjectiveTo explore the expression and function of lncRNA XIST in Th17 cells in IgA nephropathy （IgAN） and examine the regulation of lncRNA XIST on TLR9 mRNA expression.MethodsCD4+T cells were isolated from peripheral blood mononuclear cells （PBMCs） and ...
Wu Yan-ping, Ma Xiao, Han Si-ping, Wang Xiao-qin   +3 more
doaj  

Identification and functional analysis of LncRNA-XIST ceRNA network in prostate cancer

BMC Cancer, 2022
Background Long non-coding RNAs (lncRNAs) play a functional role in the progression of prostate cancer (PCa). However, the molecular mechanism, expression, or function of the lncRNA XIST in PCa is not well understood.
Jie Wang, Jie Huang, Yingxue Guo, Yuli Fu, Yifang Cao, Kang Zhou, Jianxiong Ma, Bodong Lv, Wenjie Huang   +8 more
doaj   +1 more source

LncRNA XIST promotes liver cancer progression by acting as a molecular sponge of miR-200b-3p to regulate ZEB1/2 expression

Journal of International Medical Research, 2021
Objective To evaluate the predictive value of long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) for survival, and determine the involvement of miRNA(miR)-200b-3p and zinc finger E-box-binding homeobox (ZEB) 1/2 in the pro-tumor effect of
Lili Liu, Hua Jiang, Hongming Pan, Xiuming Zhu   +3 more
doaj   +1 more source

LncRNA XIST facilitates the odontogenic differentiation of dental pulp stem cells via the FUS/ZBTB16 [PDF]

Journal of Applied Oral Science
Objective This study aims to explore the regulatory mechanism of long noncoding RNA X inactive specific transcript (lncRNA XIST) in the odontogenic differentiation of human dental pulp stem cells (hDPSCs).
Ruiqing CHENG, Honglei SUN, Xiaotong QIAO, Xuefang CHEN   +3 more
doaj   +1 more source

Long Non-coding RNA X-Inactive Specific Transcript Mediates Cell Proliferation and Intrusion by Modulating the miR-497/Bcl-w Axis in Extranodal Natural Killer/T-cell Lymphoma

Frontiers in Cell and Developmental Biology, 2020
The present study was directed toward laying new findings for Extranodal natural killer/T-cell lymphoma (ENKL)-oriented therapy with a focus on long non-coding RNA (lncRNA)–microRNAs (miRNAs)–mRNA interaction.
Qinhua Liu, Ruonan Ran, Zhengsheng Wu, Xiaodan Li, Qingshu Zeng, Ruixiang Xia, Yalei Wang   +6 more
doaj   +1 more source

lncRNA X‐inactive‐specific transcript is a potential biomarker related to changes in CD4+ T cell levels in systemic lupus erythematosus

Rheumatology & Autoimmunity, 2022
Background Systemic lupus erythematosus (SLE) is a particularly heterogeneous autoimmune disease. This study was intended to clarify the correlations between X‐inactive‐specific transcript (XIST) expression and SLE clinical features and the contribution ...
Qi Cheng, Xin Chen, Jieying Xu, Mo Chen, Peiyu Zhang, Huaxiang Wu, Yan Du   +6 more
doaj   +1 more source