Results 51 to 60 of about 16,717 (221)
Molecular Medicine, 2021 Background Long non-coding RNA (lncRNA) XIST has been implicated in the progression of a variety of tumor diseases. The purpose of this study was to explore the molecular role of lncRNA XIST in human hepatitis B virus (HBV)-related hepatocellular ...
Jiancheng Wang +10 more
doaj +1 more source
p53-regulated Xist modulation features Tfdp1 activation.
, 2023 We recently described a sex-specific transcriptional regulation mechanism, found in physiologically relevant settings in breast cancer cells in vitro and in cells of the embryo in mice and humans, wherein mutation or loss of the p53 tumor suppressor ...
Shahan Mamoor
core +1 more source
miR-34a-mediated regulation of XIST in female cells under inflammation
, 2018 Botros B Shenoda,1 Yuzhen Tian,1 Guillermo M Alexander,2 Enrique Aradillas-Lopez,2,3 Robert J Schwartzman,2 Seena K Ajit1 1Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, USA; 2Neurology, Drexel University College of
Yuzhen Tian +11 more
core +1 more source
Jpx RNA Activates Xist by Evicting CTCF [PDF]
, 2013 SummaryIn mammals, dosage compensation between XX and XY individuals occurs through X chromosome inactivation (XCI). The noncoding Xist RNA is expressed and initiates XCI only when more than one X chromosome is present. Current models invoke a dependency
Szanto, Attila +5 more
core +1 more source
International Journal of Immunopathology and Pharmacology, 2023 Objectives This experimental study aims to investigate the role of long noncoding RNA X-inactive specific transcript (lncRNA XIST) in the microglial polarization and microglia-mediated neurotoxicity in Alzheimer’s disease (AD). Methods The levels of XIST
Kun-Peng Zhao +4 more
doaj +1 more source
Functional analysis of Xist-mediated silencing [PDF]
, 2017 The lncRNA Xist is the master regulator of X chromosome inactivation in female mammals. Its mono-allelic expression triggers a cascade of well characterised events leading to the stable silencing of the X chromosome.
Pintacuda, Greta
core +1 more source
Genomic imprinting of Xist by maternal H3K27me3
, 2022 Maternal imprinting at the Xist gene is essential to achieve paternal allele-specific imprinted X-chromosome inactivation (XCI) in female mammals. However, the mechanism underlying Xist imprinting is unclear.
Inoue, Azusa +3 more
core +2 more sources
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Systematic Discovery of Xist RNA Binding Proteins [PDF]
, 2015 SummaryNoncoding RNAs (ncRNAs) function with associated proteins to effect complex structural and regulatory outcomes. To reveal the composition and dynamics of specific noncoding RNA-protein complexes (RNPs) in vivo, we developed comprehensive ...
Flynn, Ryan A. +8 more
core +1 more source
p53-regulated Xist modulation features Mllt1 activation.
, 2023 We recently described a sex-specific transcriptional regulation mechanism, found in physiologically relevant settings in breast cancer cells in vitro and in cells of the embryo in mice and humans, wherein mutation or loss of the p53 tumor suppressor ...
Shahan Mamoor
core +1 more source