Results 61 to 70 of about 16,717 (221)

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source

Beyond sequence homology: Cellular biology limits the potential of XIST to act as a miRNA sponge.

PLoS ONE, 2019
IntroductionThe sponging of microRNAs by a long non-coding RNA (lncRNA) away from their coding gene targets is a conceptually-simple, yet biologically-complex method of lncRNA-mediated gene regulation.
Erin A Marshall, Greg L Stewart, Adam P Sage, Wan L Lam, Carolyn J Brown   +4 more
doaj   +1 more source

Type I Interferon Drives Dysfunction of a Distinct CD8+ HLA‐DRB1+ T Cell Subset in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is characterized by type I interferon (IFN) signaling and adaptive immune dysregulation. We previously identified hypomethylation of HLA‐DRB1 and STAT1 in SLE CD8+ T cells, enabling aberrant IFN‐driven HLA‐DRB1 expression and expansion of a distinct CD8+ T cell subset. This study characterized CD8+ HLA‐DRB1+
Huizhong Long, Elio Carmona, Mikhail G. Dozmorov, Amr H. Sawalha   +3 more
wiley   +1 more source

A protein assembly mediates Xist localization and gene silencing [PDF]

, 2020
Nuclear compartments have diverse roles in regulating gene expression, yet the molecular forces and components that drive compartment formation remain largely unclear.
Anthony Chau, Black, Douglas L., Robin McKee, Sika Zheng, Douglas. L. Black, Serizay, Jacques, Leonhardt, Heinrich, Mancia Leon, Walter R, Zheng, Sika, Xiao-Jun Wang, Guttman, Mitchell, Chronis, Konstantinos, Chau, Anthony, Shan Sabri, Chronis, Constantinos, Mitchell Guttman, McKee, Robin, Papp, Bernadett, Sabri, Shan, Jacques Serizay, Heinrich Leonhardt, Mancia-Leon, Walter R., Kathrin Plath, Pandya-Jones, Amy, Chitiashvili, Tsotne, Constantinos Chronis, Plath, Kathrin, Andrey Damianov, Black, Douglas L, Wang, Xiao-Jun, Markaki, Yolanda, Amy Pandya-Jones, Damianov, Andrey, Tsotne Chitiashvili, Chen, Chun-Kan, Walter R. Mancia Leon, Chun-Kan Chen, Yolanda Markaki, Bernadett Papp   +38 more
core   +1 more source

Carboplatin Inhibits the Progression of Retinoblastoma Through IncRNA XIST/miR-200a-3p/NRP1 Axis

Drug Design, Development and Therapy, 2020
Hong Zhao,1 Jingjing Wan,1 Yu Zhu2 1Department of Ophthalmic Outpatient, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, People’s Republic of China; 2The Fifth Department of Ophthalmology, The First ...
Zhao H, Wan J, Zhu Y
doaj  

LncRNA XIST is involved in rheumatoid arthritis fibroblast-like synoviocytes by sponging miR-126-3p via the NF-κB pathway

Autoimmunity, 2021
The role and mechanism of lncRNA XIST (XIST) in the development of rheumatoid arthritis (RA) was explored in this study. RT-qPCRs were performed to detect the expression of XIST and miR-126-3p in synovial tissues and cells.
Wei Liu, Jing Song, Xingyu Feng, Haolong Yang, Wei Zhong   +4 more
doaj   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

XIST sponges miR-320d to promote chordoma progression by regulating ARF6

Journal of Bone Oncology, 2022
Background: Long non-coding RNAs (lncRNAs) have been demonstrated to play important roles in various tumors, including chordoma. The purpose of this study was to investigate the role and mechanism of lncRNA X-inactive specific transcript (XIST) in ...
Yonggang Wang, Zhouzhou Tang, Weichun Guo   +2 more
doaj   +1 more source

Engineered molecular diagnostic strategies for hepatocellular carcinoma: Integrating flexible photonic barcodes, liquid biopsies, and AI‐enhanced sensing platforms

FlexMat, EarlyView.
Abstract Early diagnosis of hepatocellular carcinoma (HCC) remains challenging because conventional serum biomarkers, especially alpha‐fetoprotein (AFP), show limited sensitivity for early‐stage disease. Recent progress in engineered molecular diagnostics provides new opportunities to improve HCC detection through integrated material, molecular, and ...
Jingzhi Xue, Wanqi Yang, Xiaoyu Liu, Xuehui Chu, Wei Li, Jinglin Wang   +5 more
wiley   +1 more source

Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression

Communications Biology, 2021
Andrea Cerase et al. report that the chromatin remodeler Chd8 is a key regulator of mammalian Xist expression and therefore X chromosome inactivation. They find that Chd8 activates Xist expression in embryonic stem cells, while in differentiating cells ...
Andrea Cerase, Alexander N. Young, Nerea Blanes Ruiz, Andreas Buness, Gabrielle M. Sant, Mirjam Arnold, Monica Di Giacomo, Michela Ascolani, Manish Kumar, Andreas Hierholzer, Giuseppe Trigiante, Sarah J. Marzi, Philip Avner   +12 more
doaj   +1 more source