Results 81 to 90 of about 16,717 (221)
The timing of XIST replication: dominance of the domain [PDF]
Human Molecular Genetics, 1999 Contiguous replicons are coordinately replicated and may be organized in temporal-spatial domains with early replication domains containing expressed genes and late ones carrying silent genes. XIST is silent on the active, early replicating X chromosome and expressed from the inactive, late replicating homolog.
S M, Gartler +3 more
openaire +2 more sources
Nuclear mRNA degradation pathway(s) are implicated in Xist regulation and X chromosome inactivation. [PDF]
, 2006 A critical step in X-chromosome inactivation (XCI), which results in the dosage compensation of X-linked gene expression in mammals, is the coating of the presumptive inactive X chromosome by the large noncoding Xist RNA, which then leads to the ...
Dietz, Harry, C. +13 more
core +1 more source
p53-regulated Xist modulation features Supt6h activation.
, 2023 We recently described a sex-specific transcriptional regulation mechanism, found in physiologically relevant settings in breast cancer cells in vitro and in cells of the embryo in mice and humans, wherein mutation or loss of the p53 tumor suppressor ...
Shahan Mamoor
core +1 more source
Epigenetic Regulation in the Pathogenesis of Periodontitis
Journal of Periodontal Research, EarlyView.The aim of this narrative literature review was to identify epigenetic marks associated with periodontitis and to place them in a biological context. The literature was reviewed based on pre‐defined criteria. Cell type specific chromatin and mRNA modifications were included.
Henrik Dommisch +3 more
wiley +1 more source
Computational and Systems Oncology, Volume 6, Issue 1, December 2026.ABSTRACT Stomach cancer (SC) or gastric cancer (GC) is one of the most common gastrointestinal malignancies. Currently, some studies based on competing endogenous RNAs (ceRNA) network analysis have been assessed for this cancer. The construction and analysis of ceRNA network is a novel approach for identification of RNA‐based biomarkers in cancer ...
Habib MotieGhader +2 more
wiley +1 more source
, 2015 (A) Immuno-FISH for Xist RNA (green) and H3K27me3 (red) before (day 0) and after (day 8) differentiation. Nuclei were counterstained with DAPI. The white arrowhead and arrow indicate representative “strong” and “weak” Xist clouds classified in Fig 2B ...
Shinichi Nakagawa (134648) +5 more
core +1 more source
X Chromosome Inactivation Is Mediated by Xist RNA Stabilization [PDF]
, 1997 Low level Xist expression can be detected from both active X chromosomes (Xa) in female embryonic stem cells prior to X inactivation. After differentiation, Xist is expressed at high levels only from the inactive X chromosome (Xi). Differentiating female
Panning, Barbara +2 more
core +1 more source
Xist RNA repeat E is essential for ASH2L recruitment to the inactive X and regulates histone modifications and escape gene expression. [PDF]
PLoS Genetics, 2017 Long non-coding RNA Xist plays a crucial role in establishing and maintaining X-chromosome inactivation (XCI) which is a paradigm of long non-coding RNA-mediated gene regulation.
Minghui Yue +5 more
doaj +1 more source
ELE: Estimating tissue‐specific long noncoding RNA gene essentiality using graph neural networks
Quantitative Biology, Volume 14, Issue 4, December 2026.Abstract A gene is essential if its loss of function results in lethality, reduced fitness, or disease. Essential genes have attracted increasing attention due to their vital functions in biological systems. Many efforts have been made to find essential protein‐coding genes.
Wan‐Ting Shi +3 more
wiley +1 more source
Transcriptional regulation of the XIST locus
, 2013 X-chromosome inactivation is a mechanism that has evolved in mammalian females allowing dosage compensation of X-linked genes. A region of the X chromosome called the Xinactivation centre (XIC) is required for X inactivation to occur.
Chapman, Andrew Glen
core +1 more source