Results 71 to 80 of about 16,717 (221)

Silencing of lncRNA XIST impairs angiogenesis and exacerbates cerebral vascular injury after ischemic stroke

Molecular Therapy: Nucleic Acids, 2021
The aim of this study was to investigate the function and regulatory mechanism of long non-coding RNA (lncRNA) X-inactive-specific transcript (XIST) in cerebral ischemic stroke (CIS).
Cong Wang, Jing Dong, Jinru Sun, Shu Huang, Feifei Wu, Xinyu Zhang, Defang Pang, Yuan Fu, Longxuan Li   +8 more
doaj   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

More with less Xist [PDF]

Proceedings of the National Academy of Sciences, 2011
Since the birth of Dolly, the first mammal produced from somatic cell nuclear transfer (SCNT), little progress has been made in the efficiency of cloning. Overall, about 0.5–2% of the embryos reconstructed by SCNT develop to term after transfer of reconstructed embryos to recipient females. In PNAS, Matoba et al.
openaire   +2 more sources

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

An Xist -dependent protein assembly mediates Xist localization and gene silencing [PDF]

, 2020
Summary Nuclear compartments play diverse roles in regulating gene expression, yet the molecular forces and components driving compartment formation are not well understood. Studying how the lncRNA Xist establishes the inactive-X-chromosome (Xi)-compartment, we found that the
Pandya-Jones, Amy, Markaki, Yolanda, Serizay, Jacques, Chitiashvilli, Tsotne, Mancia, Walter, Damianov, Andrey, Chronis, Costantinos, Papp, Bernadett, Chen, Chun-Kan, McKee, Robin, Wang, Xiao-Jun, Chau, Anthony, Leonhardt, Heinrich, Zheng, Sika, Guttman, Mitchell, Black, Douglas L., Plath, Kathrin   +16 more
openaire   +1 more source

Children Born Using Ejaculated Sperm From Men With Klinefelter Syndrome. Is Sperm Production Associated With Testicular Volume?

Andrology, EarlyView.
ABSTRACT Background A large number of children have been born using testicular sperm from men with Klinefelter syndrome (KS), whereas reports of children conceived using ejaculated sperm are rare. Objective To review all published cases of children conceived using ejaculated sperm from men with KS, assess their health and karyotype, and evaluate ...
Jens Fedder, Freja Sørensen
wiley   +1 more source

Tsix Silences Xist through Modification of Chromatin Structure [PDF]

, 2005
SummaryX inactivation is controlled by Xist and its antisense gene, Tsix, neither of which encodes a protein. Xist is essential for X inactivation to occur in cis, and its differential expression is a key event in the initiation of X inactivation.
Sado, Takashi, Sasaki, Hiroyuki, Hoki, Yuko   +2 more
core   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Cell lineage specific distribution of H3K27 trimethylation accumulation in an in vitro model for human implantation [PDF]

, 2012
Female mammals inactivate one of their two X-chromosomes to compensate for the difference in gene-dosage with males that have just one X-chromosome. X-chromosome inactivation is initiated by the expression of the non-coding RNA Xist, which coats the X ...
Weimar, Charlotte H. E., Weimar, C.H., Heijnen Cobi J., Kuijk Ewart W., Kuijk, E.W., Fauser, B.C., Lopes, S.M.C.D., Bart C J M Fauser, Ewart W Kuijk, Geijsen Niels, Weimar Charlotte H. E., Macklon Nick, Kuijk, Ewart W., Teklenburg, G., Fauser Bart C. J. M., Susana M Chuva de Sousa Lopes, Macklon, N., Teklenburg Gijs, Macklon, Nick, Niels Geijsen, Lopes, S.M., Weimar, C.H.E., Fauser, Bart C. J. M., Teklenburg, Gijs, Geijsen, Niels, Nick Macklon, Geijsen, N., Cobi J Heijnen, Charlotte H E Weimar, Heijnen, Cobi J., Fauser, B.C.J.M., Heijnen, C.J., Chuva de Sousa Lopes Susana M., Chuva de Sousa Lopez, Susana M., Gijs Teklenburg   +34 more
core   +1 more source

Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies

Cancer Science, EarlyView.
Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang, Junyi Xiong, Li Ying, Yanyang Zeng, Ziqiang Ouyang, Mei Liu, Meihua Li   +6 more
wiley   +1 more source