Results 41 to 50 of about 16,717 (221)

Retinoic Acid Accelerates Downregulation of the Xist Repressor, Oct4, and Increases the Likelihood of Xist Activation When Tsix is Deficient [PDF]

, 2010
Background: Imbalances in X-linked gene dosage between the sexes are resolved by transcriptionally silencing one of two X-chromosomes in female cells of the early mammalian embryo. X-inactivation is triggered by expression of the non-coding Xist gene. In
Ahn, Janice, Janice Y. Ahn, Lee, Jeannie, Jeannie T. Lee   +3 more
core   +1 more source

The Long Non-Coding RNA XIST Interacted with MiR-124 to Modulate Bladder Cancer Growth, Invasion and Migration by Targeting Androgen Receptor (AR)

Cellular Physiology and Biochemistry, 2017
Backgrounds/Aims: Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is involved in the progression of several tumors. The interaction between lncRNA and miRNA or miRNA’s target genes is reported to play crucial roles in malignancy.
Yaoyao Xiong, Long Wang, Yuan Li, Minfeng Chen, Wei He, Lin Qi   +5 more
doaj   +1 more source

Revealing the Mechanism of Xist-mediated Silencing [PDF]

, 2018
Xist initiates XCI by spreading across the future inactive X-chromosome, excluding RNA polymerase II, recruiting the polycomb repressive complex and its associated repressive chromatin modifications, and repositioning active genes into a ...
Chen, Chun-Kan
core   +1 more source

Long noncoding RNA XIST knockdown relieves the injury of microglia cells after spinal cord injury by sponging miR-219-5p

Open Medicine, 2021
Long noncoding RNAs have been demonstrated to play crucial roles in the pathogenesis of spinal cord injury (SCI). In this study, we aimed to explore the roles and underlying mechanisms of lncRNA X-inactive specific transcript (XIST) in SCI progression ...
Zhong Xueren, Bao Yongzheng, Wu Qiang, Xi Xinhua, Zhu Wengang, Chen Sanmei, Liao Junjian   +6 more
doaj   +1 more source

Xist expression from an Xist YAC transgene carried on the mouse Y chromosome [PDF]

Human Molecular Genetics, 1996
We have constructed mouse transgenic lines carrying a YAC clone encompassing the Xist gene in order to investigate the factors influencing Xist expression and the initiation of X-inactivation. Two transgenic lines were derived, one carrying four copies integrated at an autosomal site and a second line carrying four copies integrated at a single site on
S, Matsuura, V, Episkopou, R, Hamvas, S D, Brown   +3 more
openaire   +2 more sources

lncRNA XIST inhibition promotes M2 polarization of microglial and aggravates the spinal cord injury via regulating miR-124–3p / IRF1 axis

Heliyon, 2023
Background: Spinal cord injury (SCI) has a high disability rate and mortality rate. Recently, LncRNA XIST has been found to be involved in the regulation of inflammatory responses. Therefore, we aimed to investigate the role of XIST in the occurrence and
Jin Yang, Zhiqiang Gong, Junjie Dong, Hangchuan Bi, Bing Wang, Kaili Du, Chunqiang Zhang, Lingqiang Chen   +7 more
doaj   +1 more source

The Long Non-Coding RNA XIST Controls Non-Small Cell Lung Cancer Proliferation and Invasion by Modulating miR-186-5p

Cellular Physiology and Biochemistry, 2017
Background/Aims: Long non-coding RNAs (lncRNAs) are key players in the development and progression of human cancers. The lncRNA XIST (X-inactive specific transcript) has been shown to be upregulated in human non-small cell lung cancer (NSCLC); however ...
Haoyou Wang, Qiming Shen, Xin Zhang, Chunlu Yang, Su Cui, Yanbin Sun, Liming Wang, Xiaoxi Fan, Shun Xu   +8 more
doaj   +1 more source

Long noncoding RNA XIST regulates brown preadipocytes differentiation and combats high-fat diet induced obesity by targeting C/EBPα

Molecular Medicine, 2022
Background Activation of brown adipose tissue (BAT) increases energy expenditure, which makes it an attractive therapeutic strategy for obesity. LncRNAs play an important role in adipocyte differentiation and regulation.
Chunyan Wu, Shu Fang, Huijian Zhang, Xiaoqiang Li, Yuejun Du, Yudan Zhang, Xiaochun Lin, Ling Wang, Xiaoqin Ma, Yaoming Xue, Meiping Guan   +10 more
doaj   +1 more source

Self-assembly and DNA binding of the blocking factor in X chromosome inactivation [PDF]

, 2007
X chromosome inactivation (XCI) is the phenomenon occurring in female mammals whereby dosage compensation of X-linked genes is obtained by transcriptional silencing of one of their two X chromosomes, randomly chosen during early embryo development. The
Prisco, Antonella, Nicodemi, Mario, Antonella Prisco, Nicodemi Mario, Nicodemi M., Mario Nicodemi, Prisco Antonella, Prisco A.   +7 more
core   +2 more sources

XIST lost induces ovarian cancer stem cells to acquire taxol resistance via a KMT2C-dependent way

Cancer Cell International, 2020
Background/aims The expression levels of long non-coding RNA XIST are significantly associated with paclitaxel (Pac) sensitivity in ovarian cancer, but the mechanism of action remains unclear.
Ruili Huang, Lijuan Zhu, Yali Zhang
doaj   +1 more source