Results 21 to 30 of about 16,717 (221)

Knockdown of lncRNA XIST Ameliorates IL-1β-Induced Apoptosis of HUVECs and Change of Tissue Factor Level via miR-103a-3p/HMGB1 Axis in Deep Venous Thrombosis by Regulating the ROS/NF-κB Signaling Pathway

Cardiovascular Therapeutics, 2022
Background. The effect of lncRNA X inactive-specific transcript (XIST) inducing cardiovascular diseases on deep vein thrombosis (DVT) and its mechanism has not been reported.
Guangxin Cao, Hua Zhou, Dong Wang, Lei Xu   +3 more
doaj   +1 more source

The roles of lncRNA XIST in cancer chemoresistance [PDF]

ExRNA, 2023
Background and Objective: Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs with a length of more than 200 nucleotides. Multiple studies have shown that lncRNAs are important molecules participating in cellular homeostasis.
Lee Chia-I, Nadiah Abu, Siti Fathiah Masre   +2 more
doaj   +1 more source

XIST promotes cell proliferation and invasion by regulating miR-140-5p and SOX4 in retinoblastoma

World Journal of Surgical Oncology, 2020
Background Retinoblastoma (RB) is the most common intraocular malignancy in children. Long non-coding RNA X-inactive specific transcript (lncRNA XIST) has been reported to be associated with RB, but research on the mechanism of XIST is not well studied ...
Yuhui Wang, Dahong Sun, Ying Sheng, Hong Guo, Fanchun Meng, Tingting Song   +5 more
doaj   +1 more source

SViswanathanLab/XIST-Males-Scripts: v1.0.0

, 2022
Somatic XIST activation and features of X chromosome inactivation in male human cancers [Sadagopan et al.
as1000, Mingkee Achom, inasim1998
core   +1 more source

Gender dimorphism in hepatocarcinogenesis—DNA methylation modification regulated X‐chromosome inactivation escape molecule XIST

Clinical and Translational Medicine, 2023
Background Sex disparities constitute a significant issue in hepatocellular carcinoma (HCC). However, the mechanism of gender dimorphism in HCC is still not completely understood.
Zhihui Dai, Sijie Wang, Xinggang Guo, Yuefan Wang, Haozan Yin, Jian Tan, Chenyang Mu, Shu‐Han Sun, Hui Liu, Fu Yang   +9 more
doaj   +1 more source

LncRNA Jpx induces Xist expression in mice using both trans and cis mechanisms. [PDF]

PLoS Genetics, 2018
Mammalian X chromosome dosage compensation balances X-linked gene products between sexes and is coordinated by the long noncoding RNA (lncRNA) Xist. Multiple cis and trans-acting factors modulate Xist expression; however, the primary competence factor ...
Sarah Carmona, Benjamin Lin, Tristan Chou, Katti Arroyo, Sha Sun   +4 more
doaj   +1 more source

YY1-induced lncRNA XIST inhibits cartilage differentiation of BMSCs by binding with TAF15 to stabilizing FUT1 expression

Regenerative Therapy, 2022
Introduction: The functional roles and mechanism of the XIST in osteoarthritis and the chondrogenic differentiation of BMSCs were clarified. Methods: The expression levels of XIST, TAF15, FUT1 and YY1 were detected through quantitative RT-PCR.
Jian-Ying He, Min Cheng, Jia-Lian Ye, Chuan-Hua Peng, Jian Chen, Bin Luo, Xian-Yu Zhang, Qiang Fu   +7 more
doaj   +1 more source

Illuminating Xist [PDF]

The Biochemist, 2015
The Central Dogma proposed that RNA, encoded by DNA in the genome, acts as the template used by cells for protein production. The simplicity of RNA as a discrete mediator of information has subsequently been challenged by the discovery of non-protein-coding RNAs.
Heather Coker, Benoit Moindrot, Greta Pintacuda, Neil Brockdorff   +3 more
openaire   +1 more source

Long non‐coding RNA XIST expedites lung adenocarcinoma progression through upregulating MDM2 expression via binding to miR‐363‐3p

Thoracic Cancer, 2020
Background Lung adenocarcinoma (LAD) is a highly aggressive malignant tumor which threatens the health and life of the population. Long non‐coding RNA X‐inactive specific transcript (XIST) and mouse double minute clone 2 (MDM2) are connected with the ...
Hao Rong, Bing Chen, Xing Wei, Jun Peng, Ke Ma, Song Duan, Jintao He   +6 more
doaj   +1 more source

Mbd2 contributes to DNA methylation-directed repression of the Xist gene [PDF]

, 2007
Transcription of the Xist gene triggers X chromosome inactivation in cis and is therefore silenced on the X chromosome that remains active. DNA methylation contributes to this silencing, but the mechanism is unknown.
Hermann, Andrea, Prokhortchouk, Anna, Adie, Karen, Hendrich, Brian, Barr, Helen, Tsai, Hsin-Hao, Berger, Jennifer, Bird, Adrian; id_orcid   +7 more
core   +1 more source