Results 11 to 20 of about 6,021,091 (244)
Histone modification and the epigenetics of X chromosome inactivation [PDF]
, 2003 Dosage compensation serves to equalise the levels of X-linked gene products between males and females. In mammals this occurs through the transcriptional silencing of the majority of the genes on one of the two female X chromosomes.
Spotswood, Hugh Timothy
core +7 more sources
Cells, 2022 X chromosome inactivation is a mammalian dosage compensation mechanism, where one of two X chromosomes is randomly inactivated in female cells. Previous studies have suggested that primed human embryonic stem cells (hESCs) maintain an eroded state of the
Roni Sarel-Gallily, Nissim Benvenisty
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Evidence of influence of genomic DNA sequence on human X chromosome inactivation. [PDF]
PLoS Computational Biology, 2006 A significant number of human X-linked genes escape X chromosome inactivation and are thus expressed from both the active and inactive X chromosomes. The basis for escape from inactivation and the potential role of the X chromosome primary DNA sequence ...
Zhong Wang +3 more
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Large-scale population study of human cell lines indicates that dosage compensation is virtually complete. [PDF]
PLoS Genetics, 2008 X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing.
Colette M Johnston +5 more
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Characterisation of inactivation domains and evolutionary strata in human X chromosome through Markov segmentation. [PDF]
PLoS ONE, 2009 Markov segmentation is a method of identifying compositionally different subsequences in a given symbolic sequence. We have applied this technique to the DNA sequence of the human X chromosome to analyze its compositional structure.
Ashwin Kelkar +3 more
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PLoS ONE, 2014 In rodent female mammals, there are two forms of X-inactivation - imprinted and random which take place in extraembryonic and embryonic tissues, respectively.
Evgeniya A Vaskova +7 more
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Mechanics and dynamics of X-chromosome pairing at X inactivation [PDF]
, 2008 At the onset of X-chromosome inactivation, the vital process whereby female mammalian cells equalize X products with respect to males, the X chromosomes are colocalized along their Xic (X-inactivation center) regions. The mechanism inducing recognition
Scialdone, Antonio +4 more
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X chromosomes alternate between two states prior to random X-inactivation. [PDF]
PLoS Biology, 2006 Early in the development of female mammals, one of the two X chromosomes is silenced in half of cells and the other X chromosome is silenced in the remaining half. The basis of this apparent randomness is not understood.
Susanna Mlynarczyk-Evans +6 more
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Self-assembly and DNA binding of the blocking factor in X chromosome inactivation [PDF]
, 2007 X chromosome inactivation (XCI) is the phenomenon occurring in female mammals whereby dosage compensation of X-linked genes is obtained by transcriptional silencing of one of their two X chromosomes, randomly chosen during early embryo development. The
Prisco, Antonella +7 more
core +2 more sources
The X chromosome and sex-specific effects in infectious disease susceptibility
Human Genomics, 2019 The X chromosome and X-linked variants have largely been ignored in genome-wide and candidate association studies of infectious diseases due to the complexity of statistical analysis of the X chromosome.
Haiko Schurz +5 more
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