Results 31 to 40 of about 8,230 (206)

Chronic immune thrombocytopenia in a child with X-linked agammaglobulinemia-an uncommon phenotype

Platelets, 2022
Autoimmune disorders are common in patients with primary immunodeficiency diseases (PIDs). However, the prevalence of autoimmunity is low in patients with X-linked agammaglobulinemia (XLA), mostly due to the absence of antibodies.
Jing Yin, Jijun Ma, Xiaoxue Liu, Jingyue Xia, Qi Ai, Chongwei Li   +5 more
doaj   +1 more source

Identification of a novel BTK variant in a Chinese family with X-linked agammaglobulinemia [PDF]

Jichu yixue yu linchuang, 2021
Objective To identify the pathogenic variant in a Chinese family with X-linked agammaglobulinemia (XLA). Methods A trio family with suspected X-linked agammaglobulinemia was recruited.
ZHANG Han, SUN Yang, WANG Rong-rong, ZHANG Wen, ZHANG Xue
doaj  

Campylobacter jejuni Pericarditis: A Case Report

Acta Médica Portuguesa, 2022
Campylobacter jejuni is one of the most common causes of enteritis. In rare cases, extraintestinal infection can occur, with a handful of cases of cardiac involvement, of which the pathophysiological mechanism is unclear.
Joao Neves-Maia, Catarina Gomes, António Marinho, Rute Alves   +3 more
doaj   +1 more source

Deletion within the Src homology domain 3 of Bruton's tyrosine kinase resulting in X-linked agammaglobulinemia (XLA). [PDF]

, 1994
The gene responsible for X-linked agammaglobulinemia (XLA) has been recently identified to code for a cytoplasmic tyrosine kinase (Bruton's agammaglobulinemia tyrosine kinase, BTK), required for normal B cell development. BTK, like many other cytoplasmic
Chen, SH, Hagemann, T, Kwan, SP, Nilsson, L, Ochs, HD, Rawlings, DJ, Saffran, DC, Smith, CI, Vihinen, M, Witte, ON, Zhang, M, Zhu, Q   +11 more
core   +1 more source

Genetic diagnosis of patients with primary agammaglobulinemia treated at third level peruvian centers

Revista Peruana de Medicina Experimental y Salud Pública, 2019
Primary agammaglobulinemia result from specific alterations in B cells, which lead to low antibody production. Diagnostic suspicion is established with a history of repeated infections, low immunoglobulins, and absence of CD19+ B lymphocytes.
Edgar Matos-Benavides, David Garcia-Gomero, Rosario Inocente-Malpartida, Wilmer Córdova-Calderón, Juan Aldave-Becerra   +4 more
doaj   +1 more source

Nodular regenerative hyperplasia in X-linked agammaglobulinemia: An underestimated and severe complication. [PDF]

J Allergy Clin Immunol, 2022
Nunes-Santos CJ, Koh C, Rai A, Sacco K, Marciano BE, Kleiner DE, Marko J, Bergerson JRE, Stack M, Rivera MM, Constantine G, Strober W, Uzel G, Fuss IJ, Notarangelo LD, Holland SM, Rosenzweig SD, Heller T.   +17 more
europepmc   +2 more sources

X-linked agammaglobulinemia

Clinical Immunology and Immunopathology, 1991
X-linked agammaglobulinemia (XLA) patients manifest a very low production of immunoglobulins (Ig) of all classes and plasma cells are virtually absent. The XLA gene plays a crucial role in the transition of pre-B cells to later B cell stages, as hardly any slg-positive B lymphocytes can be detected.
E, Timmers, M, de Weers, F W, Alt, R W, Hendriks, R K, Schuurman   +4 more
openaire   +2 more sources

THE RELATIONSHIP BETWEEN THE EFFECT OF IMMUNOGLOBULIN THERAPY AND THE FUNCTIONAL POTENCIES OF THE CELLULAR LINK OF THE IMMUNE SYSTEM IN X-LINKED AGAMMAGLOBULINEMIA

Медицинский вестник Юга России, 2020
Objective: to evaluate the effectiveness of intravenous immunoglobulins in X-linked agammaglobulinemia, to identify changes in the cellular link of the innate and adaptive immune response associated with an insufficient effect of replacement therapy ...
L. P. Sizyakina, I. I. Andreeva, D. I. Danilova   +2 more
doaj   +1 more source

Targeting Brutons Tyrosine Kinase in Chronic Lymphocytic Leukemia at the Crossroad between Intrinsic and Extrinsic Pro-survival Signals [PDF]

, 2016
Chemo immunotherapies for chronic lymphocytic leukemia (CLL) showed a positive impact on clinical outcome, but many patients relapsed or become refractory to the available treatments.
Facco, Monica, Frezzato, Federica, Martini, Veronica, Semenzato, Gianpietro, Severin, Filippo, Trentin, Livio, Trimarco, Valentina, Visentin, Andrea   +7 more
core   +1 more source

Optimization of immunoglobulin substitution therapy by a stochastic immune response model [PDF]

, 2009
Background: The immune system is a complex adaptive system of cells and molecules that are interwoven in a highly organized communication network. Primary immune deficiencies are disorders in which essential parts of the immune system are absent or do ...
Marc Thilo Figge, Derya Unutmaz, E Mix, CA Janeway, ICM MacLennan, T Manser, M Meyer-Hermann, MT Figge, L Marodi, OC Bruton, RH Buckley, HB Gaspar, D Vetrie, S Tsukadab, JS Orange, M Stangel, M Berger, MM Eibl, J Kirmse, A Gardulf, ML Moore, H Milgrom, J Bayry, AG MacGregor, H Fujikawa, JF Van Impe, M Peleg, AS Perelson, WH Press, H Risken, MD Kazatchkine, T Tha-In, J Bayry, V Hurez, S Kaveri, P Aukrust, J Andersson, T Jungi, M Stangel, T Takai, N Prasad, MT Figge   +41 more
core   +1 more source