Results 51 to 60 of about 161,849 (206)

COVID-19 and X-linked agammaglobulinemia (XLA) – insights from a monogenic antibody deficiency

Current Opinion in Allergy and Clinical Immunology, 2021
Purpose of review The clinical outcomes from COVID-19 in monogenic causes of predominant antibody deficiency have pivotal implications for our understanding of the antiviral contribution of humoral immunity.
Mark J. Ponsford, B. Shillitoe, I. Humphreys, A. Gennery, S. Jolles   +4 more
semanticscholar   +1 more source

Optimizing Integration and Expression of Transgenic Bruton's Tyrosine Kinase for CRISPR-Cas9-Mediated Gene Editing of X-Linked Agammaglobulinemia.

The CRISPR Journal, 2021
X-linked agammaglobulinemia (XLA) is a monogenic primary immune deficiency characterized by very low levels of immunoglobulins and greatly increased risks for recurrent and severe infections.
David Gray, Isaac Villegas, Joseph D. Long, Jasmin L. Santos, A. Keir, Alison Abele, C. Kuo, D. Kohn   +7 more
semanticscholar   +1 more source

X-linked agammaglobulinemia

Clinical Immunology and Immunopathology, 1991
X-linked agammaglobulinemia (XLA) patients manifest a very low production of immunoglobulins (Ig) of all classes and plasma cells are virtually absent. The XLA gene plays a crucial role in the transition of pre-B cells to later B cell stages, as hardly any slg-positive B lymphocytes can be detected.
R.K.B. Schuurman, M. De Weers, F.W. Alt, R.W. Hendriks, E. Timmers   +4 more
openaire   +3 more sources

Genetic diagnosis of patients with primary agammaglobulinemia treated at third level peruvian centers

Revista Peruana de Medicina Experimental y Salud Pública, 2019
Primary agammaglobulinemia result from specific alterations in B cells, which lead to low antibody production. Diagnostic suspicion is established with a history of repeated infections, low immunoglobulins, and absence of CD19+ B lymphocytes.
Edgar Matos-Benavides, David Garcia-Gomero, Rosario Inocente-Malpartida, Wilmer Córdova-Calderón, Juan Aldave-Becerra   +4 more
doaj   +1 more source

Combined Treatment of Progressive Encephalitis in an X-linked Agammaglobulinemia Patient.

Iranian Journal of Allergy, Asthma and Immunology, 2023
Most patients with X-linked agammaglobulinemia are susceptible to infections, while some cases also suffer from inflammatory or autoimmune complications.
M. Yamazaki-Nakashimada, Patricia Herrera-Mora, Alfonso Mahrx-Bracho, G. López-Herrera, Juan Carlos Bustamante-Ogando, S. Scheffler-Mendoza   +5 more
semanticscholar   +1 more source

THE RELATIONSHIP BETWEEN THE EFFECT OF IMMUNOGLOBULIN THERAPY AND THE FUNCTIONAL POTENCIES OF THE CELLULAR LINK OF THE IMMUNE SYSTEM IN X-LINKED AGAMMAGLOBULINEMIA

Медицинский вестник Юга России, 2020
Objective: to evaluate the effectiveness of intravenous immunoglobulins in X-linked agammaglobulinemia, to identify changes in the cellular link of the innate and adaptive immune response associated with an insufficient effect of replacement therapy ...
L. P. Sizyakina, I. I. Andreeva, D. I. Danilova   +2 more
doaj   +1 more source

JOINT DISEASE IN CHILDREN WITH X-LINKED AGAMMAGLOBULINEMIA

Journal of IMAB, 2013
Patients with X-linked agammaglobulinemia (XLA) are prone to recurrent bacterial infections due to low levels of immunoglobulins. Clinical symptoms include recurrent bacterial otitis media, bronchitis, pneumonia, meningitis, skin infection and arthritis ...
Lidija Kareva, Kristina Mironska, Katarina Stavric   +2 more
doaj   +1 more source

Disseminated Spiroplasma apis Infection in Patient with Agammaglobulinemia, France

Emerging Infectious Diseases, 2018
We report a disseminated infection caused by Spiroplasma apis, a honeybee pathogen, in a patient in France who had X-linked agammaglobulinemia. Identification was challenging because initial bacterial cultures and direct examination by Gram staining were
Nicolas Etienne, Laurent Bret, Cécile Le Brun, Hervé Lecuyer, Josquin Moraly, Fanny Lanternier, Olivier Hermine, Agnès Ferroni, Marc Lecuit, Sabine Pereyre, Laure Beven, Olivier Lortholary   +11 more
doaj   +1 more source

X-linked agammaglobulinemia with bronchiectasis and infection： a case report [PDF]

Zhenduanxue lilun yu shijian
X-linked agammaglobulinemia (XLA) is a rare disease characterized by severe hypogammaglobulinemia, antibody deficiency, and recurrent infections. This study reports a case of X-linked agammaglobulinemia combined with bronchiectasis and infection.
LIN Jiayuan, CHENG Qijian, CHEN Ling
doaj   +1 more source

BTKbase: the mutation database for X-linked agammaglobulinemia [PDF]

Human Mutation, 2006
X-linked agammaglobulinemia (XLA) is a hereditary immunodeficiency caused by mutations in the gene encoding Bruton tyrosine kinase (BTK). XLA patients have a decreased number of mature B cells and a lack of all immunoglobulin isotypes, resulting in susceptibility to severe bacterial infections. XLA-causing mutations are collected in a mutation database
C. I. Edvard Smith, Mauno Vihinen, Jouni Väliaho   +2 more
openaire   +3 more sources