Results 1 to 10 of about 382,520 (299)

X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL [PDF]

EMBO Molecular Medicine, 2022
Acute lymphoblastic leukemia (ALL) represents the most frequent malignancy in children, and relapse/refractory (r/r) disease is difficult to treat, both in children and adults.
Michela Carlet, Karin Schmelz, Jenny Vergalli, Tobias Herold, Daniela Senft, Vindi Jurinovic, Thomas Hoffmann, Jutta Proba, Nina Weichert, Christian Junghanß, Mareike Roth, Georg Eschenburg, Malwine Barz, Günter Henze, Cornelia Eckert, Angelika Eggert, Johannes Zuber, Patrick Hundsdoerfer, Irmela Jeremias   +18 more
doaj   +2 more sources

Subcellular localization of X-linked inhibitor of apoptosis protein (XIAP) in cancer: Does that matter? [PDF]

BBA Advances, 2022
X-linked inhibitor of apoptosis protein (XIAP) finely tunes the balance between survival and death to control homeostasis. XIAP is found aberrantly expressed in cancer, which has been shown to promote resistance to therapy-induced apoptosis and confer ...
BS Mendonça, CA Ferreira, RC Maia, G Nestal de Moraes   +3 more
doaj   +2 more sources

Apoptosis in HUVECs induced by microRNA-616-3p via X-linked inhibitor of apoptosis protein targeting. [PDF]

Exp Ther Med, 2021
Atherosclerosis causes stroke and coronary heart disease and is associated with a high mortality rate worldwide. However, the pathogenesis of atherosclerosis remains unclear. Endothelial cell apoptosis is one of the early changes observed in atherosclerosis.
Chen H, Liu X, Wu Y, Wu X, Wen X, Lu Y, Zhao X.   +6 more
europepmc   +4 more sources

Role of X-linked Inhibitor of Apoptosis Protein as Cancer Biomarker [PDF]

Journal of Clinical and Diagnostic Research, 2017
X-linked Inhibitor of Apoptosis Protein (XIAP), is one of the most important apoptotic inhibitors that plays a vital role in regulating various aspects of cell functions including cell cycle progression, arrest, and apoptosis.
Manoj Pandey, Manisha Shrivastava, Shweta Mishra, Rashmi Bathri   +3 more
doaj   +2 more sources

Constructing a novel competing Endogenous RNAs network based on NR3C1 and X-linked inhibitor of apoptosis protein genes reveals potential prognostic biomarkers in colorectal cancer [PDF]

Journal of Research in Medical Sciences, 2022
Background: Long noncoding RNAs (lncRNAs) have been recognized as the main modulatory molecules in various cancers and perform as competing endogenous RNAs (ceRNAs).
Mohammad Abdolvand, Minoosh Sadeghi, Mohammad Hassan Emami, Alireza Fahim, Hojjatolah Rahimi, Elham Amjadi, Abdolmehdi Baghaei, Shirin Abdolvand, Fatemeh Maghool, Sara Feizbakhshan, Sharareh Salmanizadeh, Ehsan Heidari, Mohammad Chehelgerdi, Mahsa Khodadoostan, Maryam Ebrahim, Faeze Ahmadi Beni, Mohammad Kazemi, Simin Hemati, Farinaz Khosravian, Hassan Rahimi, Alireza Samadian, Mansoor Salehi   +21 more
doaj   +2 more sources

Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). [PDF]

J Biol Chem, 2016
Akt negatively regulates apoptotic pathways at a premitochondrial level through phosphorylation and modulation of proteins such as Bad, Forkhead proteins, and GSK-3beta. Akt has also been shown to protect cell death at a post-mitochondrial level, although its downstream targets have not been well documented.
Dan HC, Sun M, Kaneko S, Feldman RI, Nicosia SV, Wang HG, Tsang BK, Cheng JQ.   +7 more
europepmc   +6 more sources

Expression of X-linked inhibitor of apoptosis protein in neoplastic thyroid disorder. [PDF]

J Korean Med Sci, 2011
X-linked inhibitor of apoptosis protein (XIAP) is associated with tumor genesis, growth, progression and metastasis, and acts by blocking caspase-mediated apoptosis. In the present study, we sought to evaluate the expression patterns of XIAP in various neoplastic thyroid disorders and determine the association between XIAP expression and ...
Yim JH, Yoon JH, Kim SA, Kim WG, Jeon MJ, Han JM, Sung TY, Kim TY, Kim WB, Hong SJ, Shong YK, Gong G.   +11 more
europepmc   +3 more sources

The X-Linked Inhibitor of Apoptosis Protein Inhibitor Embelin Suppresses Inflammation and Bone Erosion in Collagen Antibody Induced Arthritis Mice [PDF]

Mediators of Inflammation, 2015
Objective. To investigate the effect of Embelin, an inhibitor of X-Linked Inhibitor of Apoptosis Protein (XIAP), on inflammation and bone erosion in a collagen antibody induced arthritis (CAIA) in mice. Methods.
Anak A. S. S. K. Dharmapatni, Melissa D. Cantley, Victor Marino, Egon Perilli, Tania N. Crotti, Malcolm D. Smith, David R. Haynes   +6 more
doaj   +2 more sources

Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP) [PDF]

FEBS Open Bio, 2014
Defects in the regulation of apoptosis are one main cause of cancer development and may result from overexpression of anti-apoptotic proteins such as the X-linked inhibitor of apoptosis protein (XIAP).
Maximilian A. Seiter, Stefan Salcher, Martina Rupp, Judith Hagenbuchner, Ursula Kiechl-Kohlendorfer, Jérémie Mortier, Gerhard Wolber, Judith M. Rollinger, Petra Obexer, Michael J. Ausserlechner   +9 more
doaj   +2 more sources

Cord blood stem cell-mediated induction of apoptosis in glioma downregulates X-linked inhibitor of apoptosis protein (XIAP).

PLoS ONE, 2010
BackgroundXIAP (X-linked inhibitor of apoptosis protein) is one of the most important members of the apoptosis inhibitor family. XIAP is upregulated in various malignancies, including human glioblastoma.
Venkata Ramesh Dasari, Kiran Kumar Velpula, Kiranpreet Kaur, Daniel Fassett, Jeffrey D Klopfenstein, Dzung H Dinh, Meena Gujrati, Jasti S Rao   +7 more
doaj   +4 more sources