Results 11 to 20 of about 382,520 (299)

Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells. [PDF]

PLoS ONE, 2017
The X-linked inhibitor of apoptosis (XIAP) is a viable molecular target for anticancer drugs that overcome apoptosis-resistance of malignant cells.
Kirti S Prabhu, Kodappully S Siveen, Shilpa Kuttikrishnan, Ahmad Iskandarani, Magdalini Tsakou, Iman W Achkar, Lubna Therachiyil, Roopesh Krishnankutty, Aijaz Parray, Michal Kulinski, Maysaloun Merhi, Said Dermime, Ramzi M Mohammad, Shahab Uddin   +13 more
doaj   +2 more sources

Lack of X-Linked Inhibitor of Apoptosis Protein Leads to Increased Apoptosis and Tissue Loss Following Neonatal Brain Injury

ASN Neuro, 2009
Neurological deficits caused by H-I (hypoxia-ischaemia) to the perinatal brain are often severely debilitating and lead to motor impairment, intellectual disability and seizures.
Tim West, Madeliene Stump, Gregory Lodygensky, Jeff J Neil, Mohanish Deshmukh, David M Holtzman   +5 more
doaj   +4 more sources

Retraction: Cord blood stem cell-mediated induction of apoptosis in glioma downregulates X-linked inhibitor of apoptosis protein (XIAP). [PDF]

PLoS ONE
PLOS One Editors
doaj   +2 more sources

Evidence for Two Modes of Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia in Human Colon Cancer Cells [PDF]

, 2013
Colorectal cancer is the third leading cause of cancer-related mortality in the world-- the main cause of death from colorectal cancer is hepatic metastases, which can be treated with isolated hepatic perfusion (IHP).
A Jemal, A Krueger, A Krueger, A Younes, AR Safa, BR Seo, C Liu, C Odoux, CH Mom, D Atallah, D Mahalingam, DB Longley, E Raymond, FA Greco, GJ Ullenhag, HJ Zeh 3rd, HR Alexander Jr., IA Mawji, IN Lavrik, J Yoo, JA Ubersax, JM Cummins, JW Yu, L Zhang, L Zhao, LR Hafström, LY Dimberg, M Irmler, M Upreti, M Vulfovich, MA Alcala Jr., MJ Lee, P Korkolopoulou, Raffaele A Calogero, S Hegewisch-Becker, S Varghese, Seog-Young Kim, SK Libutti, T Bartke, T Ruers, T Trarbach, TR Wilson, W Gao, X Song, X Song, X Song, Xinxin Song, Y Jin-Song, Y Lin, YJ Lee, YL Zhang, Yong J. Lee, Z El Fajoui   +52 more
core   +15 more sources

Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein. [PDF]

J Mol Cell Biol, 2016
Xu Y, Yang W, Shi J, Shi J, Zetter BR.
europepmc   +4 more sources

Fragment-Based Design of Small Molecule X-Linked Inhibitor of Apoptosis Protein Inhibitors [PDF]

Journal of Medicinal Chemistry, 2008
We report on a general structure- and NMR-based approach to derive druglike small molecule inhibitors of protein-protein interactions in a rapid and efficient manner. We demonstrate the utility of the approach by deriving novel and effective SMAC mimetics targeting the antiapoptotic protein X-linked inhibitor of apoptosis protein (XIAP).
Jui-Wen, Huang, Ziming, Zhang, Bainan, Wu, Jason F, Cellitti, Xiyun, Zhang, Russell, Dahl, Chung-Wai, Shiau, Kate, Welsh, Aras, Emdadi, John L, Stebbins, John C, Reed, Maurizio, Pellecchia   +11 more
openaire   +2 more sources

Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications [PDF]

, 2012
Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes.
Fulda, Simone, Rajalingam, Krishnaraj, Dikic, Ivan   +2 more
core   +2 more sources

Efficacy of phosphocreatine pre-administration on XIAP and Smac in ischemic penumbra of rats with focal cerebral ischemia reperfusion injury [PDF]

Acta Cirúrgica Brasileira, 2018
Purpose: To observe the efficacy of phosphocreatine pre-administration (PCr-PA) on X-linked inhibitor of apoptosis protein (XIAP), the second mitochondia-derived activator of caspase (Smac) and apoptosis in the ischemic penumbra of rats with focal ...
Wei Wang, Qi Wang, Wanyou Yu, Lianhua Chen, Zhong Li   +4 more
doaj   +1 more source

Role for X-linked Inhibitor of Apoptosis Protein Upstream of Mitochondrial Permeabilization [PDF]

Journal of Biological Chemistry, 2010
Apoptosis is controlled by a signaling equilibrium between prosurvival and proapoptotic pathways, such that unwanted apoptosis is avoided, but when required it occurs rapidly and efficiently. Many apoptosis regulators display dual roles, depending upon whether a cell has received an apoptotic stimulus or not.
Owens, Thomas W., Foster, Fiona M., Valentijn, Anthony, Gilmore, Andrew P., Streuli, Charles H.   +4 more
openaire   +3 more sources

Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein [PDF]

Biochemical Journal, 2003
The execution phase of apoptosis is under the control of members of the inhibitor of apoptosis (IAP) family of zinc finger proteins. Several of these proteins contain a C-terminal RING (really interesting new gene) domain that has been postulated to regulate ubiquitination of themselves or their target proteins, thereby modulating thresholds for ...
Hwain, Shin, Kazuya, Okada, John C, Wilkinson, Katherine M, Solomon, Colin S, Duckett, John C, Reed, Guy S, Salvesen   +6 more
openaire   +2 more sources