Results 261 to 270 of about 382,520 (299)

The X-linked inhibitor of apoptosis protein inhibits taxol-induced apoptosis in LNCaP cells

Urological Research, 2003
To clarify the roles of the X-linked inhibitor of apoptosis protein (XIAP), we investigated the effects of XIAP overexpression on taxol-induced cell growth arrest and apoptosis in the prostate cancer cell line (LNCaP). After the transfection of XIAP cDNA into LNCaP cells, we established clonal cell lines that overexpressed XIAP and examined the taxol ...
Takeo, Nomura, Hiromitsu, Mimata, Yusuke, Takeuchi, Hideyuki, Yamamoto, Eishichi, Miyamoto, Yoshio, Nomura   +5 more
openaire   +2 more sources

Sensitization of Glioma Cells by X-Linked Inhibitor of Apoptosis Protein Knockdown

Oncology, 2012
<b><i>Objective:</i></b> Glioblastomas are a kind of cancer with high resistance to treatments, requiring more efficient alternatives of treatment. X-linked inhibitor of apoptosis (XIAP) is highly expressed in gliomas and, due to its inhibition of caspases, can participate in resistance to therapy. Here we test the sensitization
Patricia L C, Lopez, Eduardo C, Filippi-Chiela, Andrew O, Silva, Elvira A A, Cordero, Daniel, Garcia-Santos, Alessandra L, Pelegrini, Gleice M, Reder, Nicolle L, Barbieri, Guido, Lenz   +8 more
openaire   +2 more sources

Immunohistochemical detection of antiapoptotic protein X-linked inhibitor of apoptosis in mammary carcinoma

Human Pathology, 2007
An immunohistochemical survey of X-linked inhibitor of apoptosis (XIAP) expression in mammary carcinoma was performed. XIAP, the most potent of the inhibitor of apoptosis family of caspase inhibitors, has been linked to tumor aggressiveness and therapeutic resistance in several malignancies and is considered an attractive target for cancer drug ...
Shabnam, Jaffer, Lurmag, Orta, Srinivas, Sunkara, Edmond, Sabo, David E, Burstein   +4 more
openaire   +2 more sources

MicroRNA-215 Regulates the Apoptosis of HCT116 Colon Cancer Cells by Inhibiting X-Linked Inhibitor of Apoptosis Protein

Cancer Biotherapy and Radiopharmaceuticals, 2021
Background: X-linked inhibitor of apoptosis protein (XIAP) is the strongest member of the family of inhibitor of apoptosis protein. Studies found that the expression of XIAP in colon cancer tissue was significantly higher than that in adjacent tissues. Studies have shown that the expression of microRNA-215 (miR-215) was significantly lower than that of
Chuanhui, Lu, Ming, Hong, Bo, Chen, Kaihua, Liu, You, Lv, Xin, Zhou, Guoqiang, Su   +6 more
openaire   +2 more sources

X-linked inhibitor of apoptosis protein increases mitochondrial antioxidants through NF-κB activation

Biochemical and Biophysical Research Communications, 2007
X chromosome-linked inhibitor of apoptosis protein is an endogenous inhibitor of caspases and is an important regulator of cell death. XIAP can also influence cell signaling, but downstream proteins affected are largely unknown. We show here using neuronal PC6.3 cells that XIAP increases the levels of antioxidants, particularly superoxide dismutase-2 ...
Minna, Kairisalo, Laura, Korhonen, Klas, Blomgren, Dan, Lindholm   +3 more
openaire   +2 more sources

Flow Cytometric Measurement of SLAM-Associated Protein and X-Linked Inhibitor of Apoptosis

2013
Flow cytometry is a valuable tool for the detection and characterization of proteins expressed by individual cells. Flow cytometry can be used to measure cell expression of 2 intracellular proteins that are involved in the regulation of immune homeostasis, SLAM-associated protein (SAP) and X-linked inhibitor of apoptosis (XIAP).
Rebecca A, Marsh, Jack J, Bleesing, Alexandra H, Filipovich   +2 more
openaire   +2 more sources

Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein

Journal of the American Chemical Society, 2021
We hypothesized that the proximity-driven ubiquitylation of E3-interacting small molecules could affect the degradation of E3 ubiquitin ligases. A series of XIAP BIR2 domain-binding small molecules was modified to append a nucleophilic primary amine. This modification transforms XIAP binders into inducers of XIAP degradation. The degradation of XIAP is
Willem den Besten, Kshitij Verma, Sayumi Yamazoe, Nicole Blaquiere, Wilson Phung, Anita Izrael-Tomasevic, Melinda M. Mulvihill, Elizabeth Helgason, Sumit Prakash, Tatiana Goncharov, Domagoj Vucic, Erin Dueber, Wayne J. Fairbrother, Ingrid Wertz, Kebing Yu, Steven T. Staben   +15 more
openaire   +2 more sources

Adenovirus-mediated down-regulation of X-linked inhibitor of apoptosis protein inhibits colon cancer

Molecular Cancer Therapeutics, 2009
Abstract Our previous studies and those of others have indicated that X-linked inhibitor of apoptosis protein (XIAP) holds promise as a target gene in colon cancer gene therapy. In this study, we constructed an adenoviral vector to deliver small hairpin RNA (shRNA) against XIAP (XIAP-shRNA) into colon cancer cells and tested its ...
Tan, VPY, Zou, B, Lam, CSC, Wong, BCY, Ma, J, Yang, M, Kwok, WC, Dai, Y, Zhang, R, Pang, R, Wang, J, Qiao, L, Lan, HY, Ye, J   +13 more
openaire   +4 more sources

Design, synthesis, and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis protein

Bioorganic & Medicinal Chemistry Letters, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Jianyong, Chen, Zaneta, Nikolovska-Coleska, Guoping, Wang, Su, Qiu, Shaomeng, Wang   +4 more
openaire   +2 more sources

Increased X-linked inhibitor of apoptosis protein (XIAP) expression exacerbates experimental autoimmune encephalomyelitis (EAE)

Journal of Neuroimmunology, 2008
Dysregulated apoptotic signaling has been implicated in most forms of cancer and many autoimmune diseases, such as multiple sclerosis (MS). We have previously shown that the anti-apoptotic protein X-linked inhibitor of apoptosis (XIAP) is elevated in T cells from mice with experimental autoimmune encephalomyelitis (EAE).
Craig S, Moore, Andrea L O, Hebb, Mathieu M, Blanchard, Candice E, Crocker, Peter, Liston, Robert G, Korneluk, George S, Robertson   +6 more
openaire   +2 more sources