Results 31 to 40 of about 382,520 (299)

Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]

, 2014
Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence.
A Castano, AM Verhagen, B Joseph, B Joseph, BP Eckelman, C Du, D Conte, DW Nicholson, E Varfolomeev, H Durkop, H Huang, JE Vince, JL Venero, K Rajalingam, K Saijo, K Saijo, M D'Amelio, M Gyrd-Hansen, M Luo, MA Burguillos, ML Block, N Muller-Sienerth, OH Voss, PL McGeer, S Kamada, SP Burke, ST Beug, T Tenev, V Bocchini, X Cui, Z Han   +30 more
core   +3 more sources

XAF1 Inhibits Cell Proliferation and Induces Apoptosis 
in Human Lung Adenocarcinoma Cell Line A549 In Vitro

Chinese Journal of Lung Cancer, 2014
Background and objective XAF1 is a factor necessary to inhibit tumor cell growth. Low XAF1 expression is associated with various tumor cells. The aim of this study is to investigate the effect and the mechanism of adenovirus vector Ad5/F35 mediated X ...
Donglai CHEN, Fuquan ZHANG, Yonghua SANG, Rongying ZHU, Hongtao ZHANG, Yongbing CHEN   +5 more
doaj   +1 more source

X-Linked Inhibitor of Apoptosis Protein as a Therapeutic Target in Metastatic Melanoma [PDF]

Journal of Investigative Dermatology, 2010
Melanoma is the most dangerous type of skin cancer, with notorious resistance to current chemotherapy and immunotherapy. In this issue, Hiscutt et al. report on the prognostic significance of X-linked inhibitor of apoptosis protein (XIAP) in melanoma.
Tian, Fang, Lee, Sam W.
openaire   +2 more sources

Mechanisms of sensorineural cell damage, death and survival in the cochlea. [PDF]

, 2015
The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well ...
Ryan, Allen F, Wong, Ann CY
core   +1 more source

X-linked Inhibitor of Apoptosis Protein (XIAP) Regulates PTEN Ubiquitination, Content, and Compartmentalization [PDF]

Journal of Biological Chemistry, 2009
Apoptotic cell death plays a normal role in various physiological processes, and deregulated apoptosis is a hallmark of several diseases, including cancer. Cell fate is dictated by the balance between pro- and antiapoptotic factors. Akt is one of these antiapoptotic factors, which must be activated through phosphorylation.
Céline, Van Themsche, Valérie, Leblanc, Sophie, Parent, Eric, Asselin   +3 more
openaire   +2 more sources

Xiap Inhibitor and Antiestrogen Embelin Abrogates Metastasis and Augments Apoptosis in Estrogen Receptor Positive Human Breast Adenocarcinoma Cell Line MCF-7 [PDF]

, 2014
Tamoxifen therapy for the treatment of hormone responsive breast cancer has limitations due to acquired resistance in the case of recurrences. Embelin, a known inhibitor of X-linked inhibitor of apoptosis protein (XIAP) was also reported to exhibit ...
Abiramasundari, G., Chetan, G.K., Divya, T., Sudhandi, G., Sumalatha, K.R.   +4 more
core   +1 more source

Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. [PDF]

, 2020
The accumulation of senescent cells (SnCs) is a causal factor of various age-related diseases as well as some of the side effects of chemotherapy. Pharmacological elimination of SnCs (senolysis) has the potential to be developed into novel therapeutic ...
Budamagunta, Vivekananda, Campisi, Judith, He, Yonghan, Li, Wen, Lv, Dongwen, Ortiz, Yuma T, Zhang, Xin, Zhang, Xuan, Zheng, Guangrong, Zhou, Daohong   +9 more
core   +1 more source

Uric acid promotes apoptosis in human proximal tubule cells by oxidative stress and the activation of NADPH oxidase NOX 4. [PDF]

PLoS ONE, 2014
Mild hyperuricemia has been linked to the development and progression of tubulointerstitial renal damage. However the mechanisms by which uric acid may cause these effects are poorly explored.
Daniela Verzola, Elena Ratto, Barbara Villaggio, Emanuele Luigi Parodi, Roberto Pontremoli, Giacomo Garibotto, Francesca Viazzi   +6 more
doaj   +1 more source

Crucial Role of Reactive Oxygen Species (ROS) for the Proapoptotic Effects of Indirubin Derivatives in Cutaneous SCC Cells

Antioxidants, 2021
Efficient drugs are needed for countering the worldwide high incidence of cutaneous squamous cell carcinoma (cSCC) and actinic keratosis. Indirubin derivatives represent promising candidates, but their effects in cSCC cells have not been reported before.
Jiaqi Zhu, Peter Langer, Claas Ulrich, Jürgen Eberle   +3 more
doaj   +1 more source

Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells [PDF]

, 2013
As inhibitor of apoptosis (IAP) proteins can regulate additional signaling pathways beyond apoptosis, we investigated the effect of the second mitochondrial activator of caspases (Smac) mimetic BV6, which antagonizes IAP proteins, on non-apoptotic ...
Eckhardt, Ines, Fulda, Simone, Jennewein, Carla, Rajalingam, Krishnaraj, Tchoghandjian, Aurélie   +4 more
core   +3 more sources