Results 51 to 60 of about 382,520 (299)

Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP

Molecular & Cellular Oncology, 2018
ARTS (Sept4_i2) is a pro-apoptotic mitochondrial tumor suppressor protein which binds to and causes degradation of XIAP (X-linked inhibitor of apoptosis).
Dana Mamriev, Sarit Larisch
doaj   +1 more source

The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells [PDF]

, 2016
Inhibitors of kinesin spindle protein Eg5 are characterized by pronounced antitumor activity. Our group has recently synthesized and screened a library of 1,3,4-thiadiazoline analogues with the pharmacophoric structure of K858, an Eg5 inhibitor.
CARRADORI, Simone, DE IULIIS, FRANCESCA, giantulli, sabrina, GIUFFRIDA, Anna, MILANA, Bernardina, SALERNO, GERARDO, SCARPA, Susanna, SILVESTRI, Ida, Taglieri, Ludovica   +8 more
core   +1 more source

XIAP and Ki-67: A Correlation Between Antiapoptotic and Proliferative Marker Expression in Benign and Malignant Tumours of Salivary Gland: An Immunohistochemical Study [PDF]

Journal of Clinical and Diagnostic Research, 2015
Background: Impaired balance between cell proliferation and apoptosis is crucial to the development of malignant neoplasm. The purpose of this study was to evaluate and compare the expression of X-Linked inhibitor of apoptotic protein (XIAP ...
Bhupesh Bhayyaji Bagulkar, Madhuri Gawande, Minal Chaudhary, Amol Ramchandra Gadbail, Swati Patil, Smita Bagulkar   +5 more
doaj   +1 more source

PARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expression [PDF]

, 2015
To overcome cancer cells resistance to pharmacological therapy, the development of new therapeutic approaches becomes urgent. For this purpose, the use of poly(ADP-ribose) polymerase (PARP) inhibitors in combination with other cytotoxic agents could ...
CAIAFA, Paola, CALABRESE, ROBERTA, CICCARONE, FABIO, Daniela Trisciuoglio, Donatella Del Bufalo, GUASTAFIERRO, Tiziana, MARIANO, GERMANO, REALE, Anna, RICCIARDI, Maria Rosaria, TAFURI, Agostino, VALENTINI, ELISABETTA, ZAMPIERI, Michele   +11 more
core   +2 more sources

(-)-Gossypol enhances epirubicin's anti-tumor effects on hepatocellular carcinoma in vitro via down-regulating X-linked inhibitor of apoptosis protein

陆军军医大学学报, 2022
Objective To investigate mechanism and effect on (-)-gossypol enhancing epirubicin killing hepatocellular carcinoma (HCC) cells. Methods HCC cells (Hep 3B and HuH7) were divided into 8 groups: control, (-)-gossypol, epirubicin, combination, si-control ...
JIANG Wenbin, SUN Liangbo, DU Yexiang, XIAO Yunhua   +3 more
doaj   +1 more source

Hydrogen gas promotes apoptosis of lung adenocarcinoma A549 cells through X-linked inhibitor of apoptosis and baculoviral inhibitor of apoptosis protein repeat-containing 3

Journal of Cancer Research and Therapeutics, 2022
Objective: Lung cancer is currently the cancer with the highest incidence and death toll worldwide. Hydrogen gas has been found to affect a variety of diseases; however, the effect of hydrogen gas on patients with lung cancer has not been reported.
Yu, Zhang, Gang, Chen, Zhenfeng, Yan, Lifei, Wang, Dongchang, Wang   +4 more
openaire   +2 more sources

Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]

, 2015
The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Francesca Cordeiro, M, Guo, L, Moss, SE, Shi, H, Stampoulis, D, Williams, JA   +5 more
core   +1 more source

Embelin: A multifaceted anticancer agent with translational potential in targeting tumor progression and metastasis

EXCLI Journal : Experimental and Clinical Sciences, 2023
Embelin, a natural para-benzoquinone product, is derived from plants of the Embelia genus, particularly Embelia ribes Burm.f. A staple in traditional medicinal formulations for centuries, Embelin's pharmacological actions are attributed to the hydroxyl ...
Adithya Jayaprakash Kamath, Alda Sara Chandy, Aina Ann Joseph, Jaggiah N. Gorantla, Asawari Dilip Donadkar, Lekshmi R. Nath, Javad Sharifi-Rad, Daniela Calina   +7 more
doaj   +1 more source

High expression of XIAP and Bcl-2 may inhibit programmed cell death in glioblastomas

Arquivos de Neuro-Psiquiatria
Glioblastoma (GBM) is the most malignant glioma and represents 29% of all brain tumors. Tumorigenesis is intimately connected with characteristics acquired in the physiologic pathway of cellular death.
Daniela Pretti da Cunha Tirapelli, Isis Lacrose Lustosa, Sarah Bomfim Menezes, Indira Maynart Franco, Andressa Romualdo Rodrigues, Fernanda Maris Peria, Alexandre Magno da Nóbrega Marinho, Luciano Neder Serafini, Carlos Gilberto Carlotti Jr, Luís Fernando Tirapelli   +9 more
doaj   +1 more source

X‐Linked inhibitor of apoptosis protein is involved in mutant SOD1‐mediated neuronal degeneration [PDF]

Journal of Neurochemistry, 2002
AbstractMutations in the superoxide dismutase 1 (SOD1) gene cause the degeneration of motor neurons in familial amyotrophic lateral sclerosis (FALS). An apoptotic process including caspase‐1 and ‐3 has been shown to participate in the pathogenesis of FALS transgenic (Tg) mouse model. Here we report that IAP proteins, potent inhibitors of apoptosis, are
Shinsuke, Ishigaki, Yideng, Liang, Masahiko, Yamamoto, Jun-ichi, Niwa, Yoshio, Ando, Tsuyoshi, Yoshihara, Hideyuki, Takeuchi, Manabu, Doyu, Gen, Sobue   +8 more
openaire   +2 more sources