Results 81 to 90 of about 11,043,474 (383)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

The Chandra Deep Field-North Survey. XIV. X-ray detected Obscured AGNs and Starburst Galaxies in the Bright Submm Source Population

, 2002
We provide X-ray constraints and perform the first X-ray spectral analyses for bright (f_850>=5mJy; S/N>=4) SCUBA sources in an 8.4'x8.4' area of the 2 Ms Chandra Deep Field-North survey containing the Hubble Deep Field-North.
A. E. Hornschemeier, Blain A. W., C. Vignali, D. M. Alexander, D. P. Schneider, Downes D., F. E. Bauer, G. Chartas, G. P. Garmire, Maiolino R., Matt G., Matt G., Rengarajan T. N., Rowan-Robinson M., S. C. Gallagher, Severgnini P., Soucail G., Vignati P., W. N. Brandt, Zezas A.   +19 more
core   +1 more source

X-ray Polarimetry of X-ray Pulsars

Galaxies
Radiation from X-ray pulsars (XRPs) was expected to be strongly linearly polarized owing to a large difference in their ordinary and extraordinary mode opacities. The launch of IXPE allowed us to check this prediction. IXPE observed a dozen X-ray pulsars, discovering pulse-phase dependent variation of the polarization degree (PD) and polarization angle
Juri Poutanen, Sergey S. Tsygankov, Sofia V. Forsblom   +2 more
openaire   +3 more sources

Scattered X-rays in x-ray photography [PDF]

Journal of the Franklin Institute, 1922
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openaire   +2 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

A Compact X-ray Source and Possible X-ray Jets within the Planetary Nebula Menzel 3 [PDF]

, 2003
We report the discovery, by the Chandra X-ray Observatory, of X-ray emission from the bipolar planetary nebula Menzel 3. In Chandra CCD imaging, Mz 3 displays hot (3-6x10^6 K) gas within its twin, coaxial bubbles of optical nebulosity, as well as a ...
Adam Frank, Bruce Balick, Eric G. Blackman, Garcia-Segura G., Guerrero M. A., Jingqiang Li, Joel H. Kastner, Kingsburgh R. L., Lopez J. A., Noam Soker, Saeqa D. Vrtlek   +10 more
core   +3 more sources

Utilizing Quantum Annealing in Computed Tomography Image Reconstruction

IEEE Transactions on Quantum Engineering
One of the primary difficulties in computed tomography (CT) is reconstructing cross-sectional images from measured projections of a physical object. There exist several classical methods for this task of generating a digital representation of the object,
Kilian Dremel, Dimitri Prjamkov, Markus Firsching, Mareike Weule, Thomas Lang, Anastasia Papadaki, Stefan Kasperl, Martin Blaimer, Theobald O. J. Fuchs   +8 more
doaj   +1 more source

Analysis of the expression of genes involved in proliferation and apoptosis in cervical intraepithelial neoplasias and cancer of the cervix uteri

Опухоли женской репродуктивной системы, 2014
The viral nature of many female genital cancers is now beyond question. By taking into account this fact, the problem of qualitative assessment ofthenatureofcervicalintraepithelialneoplasia(CIN)anditsfocusonprogressiontoinvasivecarcinomabecomesquitenatu ...
V. K. Bozhenko, L. A. Ashrafyan, I. B. Antonova, N. V. Melnikova, O. N. Burmenskaya, D. Yu. Trofimov, E. A. Kudinova, L. Z. Khunova, A. V. Slonov, O. P. Bliznyukov   +9 more
doaj   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source