Results 171 to 180 of about 59,512 (219)

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

Methods to Study the Molecular Mechanism and Drive the Design of Protein Degraders. [PDF]

Chem Rev
Crowe C, Ciulli A.
europepmc   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Guest-induced porous gating of a fluorescent nonporous adaptive crystal for efficient radioactive iodine sorption. [PDF]

Nat Commun
Zhang Q, Liu X, Guo Y, Liu S, Ge F, Gong Y, Zhao M, Song Y, Liu Y, Sun D, Hu Q.   +10 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

From Film Processing to Microphase Orientation: Structure-Property Relationships in Commercial PBSA/PLA Blend Films. [PDF]

Polymers (Basel)
Geertz G, Böhler S, Barton B, Malz F, Bohn A, Kahle O, Brüll R, Balko J.   +7 more
europepmc   +1 more source

X-ray fluorescence spectroscopy for rapid identification of cathode chemistry in lithium-ion battery recycling. [PDF]

Commun Eng
Ren F, Vidal V, Campos A, Vacandio F, Angeletti B, Giffard I, Chaurand P, Borschneck D, Syahputra S, Rose J, Saadoune I, Levard C.   +11 more
europepmc   +1 more source

Interaction of two parenchyma ray types regulates redwood heartwood deposition. [PDF]

Sci Rep
Chin ARO, Sillett SC, Laín O, Voggeneder K, Orozco J, Moore Z, Bast M, Parkinson ND, Guzmán-Delgado P.   +8 more
europepmc   +1 more source

Dispensable players: N-WASP and WASP are not crucial for homology-directed DNA repair. [PDF]

EMBO Rep
Le Phan TH, Buchard A, Brakebusch C.
europepmc   +1 more source

Demonstrating soft X-ray tomography in the lab for correlative cryogenic biological imaging using X-rays and light microscopy. [PDF]

Sci Rep
O'Connor S, Rogers D, Kobylynska M, Geraets JA, Thaysen K, Egebjerg JM, Brink MC, Herbsleb L, Salakova M, Fuchs L, Alves F, Feldmann C, Ekman A, Sheridan P, Fyans W, McEnroe T, O'Reilly F, Fahy K, Fleck RA, Wüstner D, Simpson JC, Walter A, Kapishnikov S.   +22 more
europepmc   +1 more source