Results 61 to 70 of about 9,803,268 (311)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
ZnO Nanowire Cold Cathode Hemispherical X‐Ray Sources
Advanced Electronic MaterialsCurved or spherical X‐ray sources are significant for use in intraoperative radiotherapy, adaptive static medical imaging, and high‐throughput industrial inspection, but they are hard to achieve using traditional thermionic cathode point electron sources.
Zhipeng Zhang +6 more
doaj +1 more source
Hydrogen-triggered X-Ray Bursts from SAX J1808.4−3658? The Onset of Nuclear Burning
The Astrophysical Journal, 2023 We present a study of weak, thermonuclear X-ray bursts from the accreting millisecond X-ray pulsar SAX J1808.4−3658. We focus on a burst observed with the Neutron Star Interior Composition Explorer on 2019 August 9, and describe a similar burst observed ...
Sierra Casten +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
A Comprehensive Comparison of Spin-up and Spin-down Episodes of 4U 1538-522 Observed with NuSTAR
The Astrophysical Journal4U 1538-522 is a persistent high-mass X-ray binary that exhibits secular spin evolution. In 2019, it underwent a torque reversal from spinning up to spinning down.
Yongfeng Hu, Long Ji, Cong Yu, Lili Yang
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
A plasma source for an imaging X-ray microscope
, 2022 Pinch Plasmas are sources of high brilliance for soft x-rays in the wavelength range from Lambda equal 0.1 nm to 20 nm. A plasma focus device emitting line radiation of hydrogen-like nitrogen (N VII) at Lambda equal 2.5 nm into the water window region ...
Neff, W. +4 more
core +1 more source
The Counterjet Dominates the Production of PeV Photons from Cyg X-3
The Astrophysical Journal LettersWe study the physical mechanisms underlying the production of orbitally modulated PeV photons from Cyg X-3, recently discovered by the LHAASO collaboration. Our key findings are as follows.
Andrzej A. Zdziarski +2 more
doaj +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Hard X-Ray Sources in Fermi UFOs
The Astrophysical JournalIdentification and/or association of unidentified γ -ray sources with lower-energy counterparts represents a key challenge in modern astronomy, due to the relatively large positional uncertainty provided by γ -ray detectors.
Alessandro Paggi +9 more
doaj +1 more source