Results 81 to 90 of about 1,327,251 (363)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

X-Ray Polarimetry of the Accreting Pulsar 1A 0535+262 in the Supercritical State with PolarLight

open access: yesThe Astrophysical Journal, 2023
The X-ray pulsar 1A 0535+262 exhibited a giant outburst in 2020, offering us a unique opportunity for X-ray polarimetry of an accreting pulsar in the supercritical state.
Xiangyun Long   +27 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Creep Characterization of Inconel 718 Lattice Metamaterials Manufactured by Laser Powder Bed Fusion

open access: yesAdvanced Engineering Materials, EarlyView., 2023
Herein, the creep characteristics of additively manufactured Inconel 718 metamaterials are investigated. The creep behavior of metamaterials and the effects of microstructural defects are assessed, and the microstructure defects are accurately captured using Kachanov's creep damage model.
Akash Singh Bhuwal   +5 more
wiley   +1 more source

The Luminosity Phase Space of Galactic and Extragalactic X-Ray Transients Out to Intermediate Redshifts

open access: yesThe Astrophysical Journal, 2023
We present a detailed compilation and analysis of the X-ray phase space of low- to intermediate-redshift (0 ≤ z ≤ 1) transients that consolidates observed light curves (and theory where necessary) for a large variety of classes of transient/variable ...
Ava Polzin   +10 more
doaj   +1 more source

An XMM-Newton View of the ANdromeda Galaxy as Explored in a Legacy Survey (New-ANGELS) I: the X-ray Source Catalogue [PDF]

open access: yesarXiv, 2023
We introduce the New-ANGELS program, an XMM-Newton survey of $\sim7.2\rm~deg^2$ area around M 31, which aims to study the X-ray populations in M 31 disk and the X-ray emitting hot gas in the inner halo of M 31 up to 30 kpc. In this first paper, we report the catalogue of 4506 detected X-ray sources, and attempt to cross-identify or roughly classify ...
arxiv  

Displacement of X-Ray Sources from Star Clusters in Starburst Galaxies [PDF]

open access: yesMon.Not.Roy.Astron.Soc. 348 (2004) L28, 2003
We examine the spatial offsets between X-ray point sources and star clusters in three starburst galaxies. We find that the X-ray sources are preferentially located near the star clusters. Because the star clusters are very good tracers of the star formation activity in the galaxies, this indicates that the X-ray sources are young objects associated ...
arxiv   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

open access: yesFEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal   +3 more
wiley   +1 more source

A Variational Beam Model for Failure of Cellular and Truss‐Based Architected Materials

open access: yesAdvanced Engineering Materials, EarlyView., 2023
Herein, a versatile and efficient beam modeling framework is developed to predict the nonlinear response and failure of cellular, truss‐based, and woven architected materials. It enables the exploration of their design space and the optimization of their mechanical behavior in the nonlinear regime. A variational formulation of a beam model is presented
Konstantinos Karapiperis   +3 more
wiley   +1 more source

X-Ray and Near-Infrared Spectroscopy of Dim X-Ray Point Sources Constituting the Galactic Ridge X-Ray Emission

open access: yesActa Polytechnica CTU Proceedings, 2014
We present the results of X-ray and Near-Infrared observations of the Galactic Ridge X-ray Emission (GRXE). We extracted 2,002 X-ray point sources in the Chandra Bulge Field (l =0°.113, b = 1°.424) down to ~10-14.8 ergscm-2s-1 in 2-8 keV band with the ...
Kumiko Morihana   +2 more
doaj   +1 more source

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