Results 51 to 60 of about 601,668 (305)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Insights into the Structure of Dot@Rod and Dot@Octapod CdSe@CdS Heterostructures [PDF]

, 2015
CdSe@CdS dot@rods with diameter around 6 nm and length of either 20, 27, or 30 nm and dot@octapods with pod diameters of ?15 nm and lengths of ?50 nm were investigated by X-ray absorption spectroscopy.
Gianolio, Diego, Cibin, G, Gavin Mountjoy (1361589), Maria Francesca Casula (1361592), Cibin, Giannantonio, Corrias, Anna, Gianolio, D, Erika Conca (1361595), Mountjoy, G, De Donato, F, Anna Corrias (1361598), De Donato, Francesco, Manna, Liberato, Casula, Maria Francesca, Manna, L, Giannantonio Cibin (1342398), Conca, Erika, Diego Gianolio (1359060), Mountjoy, Gavin, Francesco De Donato (1263684), Liberato Manna (1285230)   +20 more
core   +1 more source

Unsupervised Machine Learning for Unbiased Chemical Classification in X-ray Absorption Spectroscopy and X-ray Emission Spectroscopy

, 2021
We report a comprehensive computational study of unsupervised machine learning for extraction of chemically relevant information in X-ray absorption near edge structure (XANES) and in valence-to-core X-ray emission spectra (VtC-XES) for classification of
Samantha, Tetef, Niranjan, Govind, Gerald, Seidler   +2 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Hard-X-ray Photoelectron Spectroscopy of Atoms and Molecules

, 2015
We review here the current status of atomic and molecular HAXPES, both experimentally and theoretically. After the era of the ESCA technique, atomic and molecular HAXPES experienced several decades when the emphasis in gas-phase research was in the soft ...
Maria Novella Piancastelli, Lindle, D. W., Simon, M., Piancastelli, Maria Novella,, Marc Simon, Dennis W. Lindle   +5 more
core   +1 more source

The nature of the X-ray transient MAXI J0556−332 [PDF]

, 2012
Phase-resolved spectroscopy of the newly discovered X-ray transient MAXIJ0556-332 has revealed the presence of narrow emission lines in the Bowen region that most likely arise on the surface of the mass donor star in this low-mass X-ray binary.
Charles, PA, Cornelisse, R., Steeghs, D., O'Brien, Kieran, Munoz-Darias, T, Israel, G., Israel, G, Charles, P. A., Steeghs, D, Casares, J, Torres, M. A. P., Muñoz-Darias, T., Casares, J., Stella, L, Campana, S, Torres, M.A.P., Torres, MAP, Campana, S., Charles, P.A., Stella, L., D'Avanzo, P, O'Brien, K, Cornelisse, R, Israel, G. L., O'Brien, K., D'Avanzo, P.   +25 more
core   +1 more source

Attosecond x-ray transient absorption spectroscopy in graphene

Physical Review Research, 2021
Real-time observations of the coherent electron dynamics induced by ultrashort light pulses in condensed-matter systems have remained elusive due to limitations in existing attosecond devices.
Giovanni Cistaro, Luis Plaja, Fernando Martín, Antonio Picón   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Investigations of ultra shallow junction ion implanted biaxial tensile strained silicon by means of X-Ray, Raman and photoacoustic techniques [PDF]

, 2012
The application of strain to the active channel region of the metal-oxide-semiconductor-field-effect-transistor (MOSFET) has become a necessary practice in integrated circuit (IC) fabrication. The introduction of strain allows increased carrier mobilities,
Horan, Ken
core