Results 21 to 30 of about 30,807 (267)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
The Astrophysical JournalWe present photometric selection of type 1 quasars in the ≈5.3 deg ^2 XMM-Large Scale Structure survey field with machine learning. We constructed our training and blind-test samples using spectroscopically identified Sloan Digital Sky Survey quasars ...
Jian Huang +6 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The NH Distribution of Hard X-Ray Selected Active Galactic Nuclei in the NEP Field
The Astrophysical JournalX-ray surveys are one of the most unbiased methods for detecting Compton-thick (CT; N _H ≥ 10 ^24 cm ^−2 ) active galactic nuclei (AGN), which are thought to comprise up to 60% of AGN within z ≲ 1.0.
Samantha Creech +11 more
doaj +1 more source
Future Perspectives for Gamma-ray Burst Detection from Space
UniverseSince their first discovery in the late 1960s, gamma-ray bursts have attracted an exponentially growing interest from the international community due to their central role in the most highly debated open questions of the modern research of astronomy ...
Enrico Bozzo +37 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The Final Season Reimagined: 30 Tidal Disruption Events from the ZTF-I Survey
The Astrophysical Journal, 2022 Tidal disruption events (TDEs) offer a unique way to study dormant black holes. While the number of observed TDEs has grown thanks to the emergence of wide-field surveys in the past few decades, questions regarding the nature of the observed optical, UV,
Erica Hammerstein +32 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Luminosity Evolution of the Hot Gas in Normal Galaxies from the Near Universe to z = 0.5
The Astrophysical JournalWe explore the evolution of the ∼10 ^7 K hot gas in normal galaxies out to redshift = 0.5 (lookback time = 5 Gyr), using X-ray luminosity functions (XLFs) built from a sample of 575 normal galaxies with z < 0.6 detected in five high-galactic-latitude ...
Dong-Woo Kim, Giuseppina Fabbiano
doaj +1 more source
The Astrophysical Journal, 2023 Open clusters are thought to be the birthplace of most stars in the galaxy. Thus, they are excellent laboratories for investigating stellar evolution, and X-ray properties of various types of stars (including binary stars, evolved stars, and compact ...
Steven Chen +6 more
doaj +1 more source