Results 41 to 50 of about 7,431,143 (302)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Luminosity Evolution of the Hot Gas in Normal Galaxies from the Near Universe to z = 0.5

The Astrophysical Journal
We explore the evolution of the ∼10 ^7 K hot gas in normal galaxies out to redshift = 0.5 (lookback time = 5 Gyr), using X-ray luminosity functions (XLFs) built from a sample of 575 normal galaxies with z < 0.6 detected in five high-galactic-latitude ...
Dong-Woo Kim, Giuseppina Fabbiano
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Smart Source Detection Framework for Lobster Eye Telescopes

The Astrophysical Journal Supplement Series
Lobster eye telescopes are designed to capture X-ray emissions from celestial objects across a broad field of view. However, the unique optical system of these telescopes leads to a cruciform pattern on the detector plane, complicating the detection of ...
Peng Jia, Yijun Zhang, Kaiyang Li, Yuan Liu, Haiwu Pan, Yushan Li   +5 more
doaj   +1 more source

The high energy X-ray probe (HEX-P): bringing the cosmic X-ray background into focus

Frontiers in Astronomy and Space Sciences
Since the discovery of the cosmic X-ray background (CXB), astronomers have strived to understand the accreting supermassive black holes (SMBHs) contributing to its peak in the 10–40 keV band.
F. Civano, X. Zhao, P. G. Boorman, S. Marchesi, S. Marchesi, T. Ananna, S. Creech, S. Creech, C.-T. Chen, C.-T. Chen, R. C. Hickox, D. Stern, K. Madsen, J. A. García, R. Silver, R. Silver, J. Aird, D. M. Alexander, M. Baloković, M. Baloković, W. N. Brandt, W. N. Brandt, W. N. Brandt, J. Buchner, P. Gandhi, E. Kammoun, E. Kammoun, S. LaMassa, G. Lanzuisi, A. Merloni, A. Moretti, K. Nandra, E. Nardini, A. Pizzetti, S. Puccetti, R. W. Pfeifle, R. W. Pfeifle, C. Ricci, C. Ricci, D. Spiga, N. Torres-Albà   +40 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

XMM-Newton surveys of the Canada-France Redshift Survey fields - I. The submillimetre/X-ray relation [PDF]

, 2003
First results from XMM–Newton observations of the Canada–France Redshift Survey (CFRS) 3-h, 10-h and 14-h fields are presented. Limited regions of two of the XMM surveys (3 and 14 h) are compared with the Canada–UK Deep Submillimetre Surveys (CUDSS ...
Gear, Walter K., Eales, Stephen Anthony, Thuan, Trinh X., Lilly, Simon, Waskett, Timothy James, Lilly, Simon J., Waskett, Timothy J., Flores, Hector, Eales, Stephen A., Webb, Tracy, Puchnarewicz, Elizabeth M., Clements, David, Stevens, Jason A., Gear, Walter Kieran, T. Webb, H. Flores, S. Lilly, S. A. Eales, E. M. Puchnarewicz, J. A. Stevens, T. X. Thuan, D. Clements, T. J. Waskett, W. K. Gear   +23 more
core   +1 more source