Results 51 to 60 of about 329,488 (298)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Luminosity Evolution of the Hot Gas in Normal Galaxies from the Near Universe to z = 0.5

The Astrophysical Journal
We explore the evolution of the ∼10 ^7 K hot gas in normal galaxies out to redshift = 0.5 (lookback time = 5 Gyr), using X-ray luminosity functions (XLFs) built from a sample of 575 normal galaxies with z < 0.6 detected in five high-galactic-latitude ...
Dong-Woo Kim, Giuseppina Fabbiano
doaj   +1 more source

Population of X-Ray Sources in the Intermediate-age Cluster NGC 3532: a Test Bed for Machine-learning Classification

The Astrophysical Journal, 2023
Open clusters are thought to be the birthplace of most stars in the galaxy. Thus, they are excellent laboratories for investigating stellar evolution, and X-ray properties of various types of stars (including binary stars, evolved stars, and compact ...
Steven Chen, Oleg Kargaltsev, Hui Yang, Jeremy Hare, Igor Volkov, Blagoy Rangelov, John Tomsick   +6 more
doaj   +1 more source

Why Optically--Faint AGN Are Faint: The Spitzer Perspective

, 2005
Optically--faint X-ray sources (those with f_X/f_R > 10) constitute about 20% of X-ray sources in deep surveys, and are potentially highly obscured and/or at high redshift. Their faint optical fluxes are generally beyond the reach of spectroscopy.
A. Alonso‐Herrero, Arnouts S., Devriendt J., G. G. Fazio, G. H. Rieke, Gilli R., J. L. Donley, J. R. Rigby, J.‐S. Huang, P. Barmby, P. G. Perez‐Gonzalez   +10 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Cosmological Evolution of the Central Engine in High-Luminosity, High-Accretion Rate AGN

Acta Polytechnica CTU Proceedings, 2014
In this paper I discuss the status of observational studies aiming at probing the cosmological evolution of the central engine in high-luminosity, high-accretion rate Active Galactic Nuclei (AGN). X-ray spectroscopic surveys, supported by extensive multi-
Matteo Guainazzi
doaj   +1 more source

X-ray sources as tracers of the large-scale structure in the Universe

, 2000
We review the current status of studies of large-scale structure in the X-ray Universe. After motivating the use X-rays for cosmological purposes, we discuss the various approaches used on different angular scales including X-ray background multipoles ...
Barcons, X., Carrera, F. J., Ceballos, M. T., Mateos, S.   +3 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Smart Source Detection Framework for Lobster Eye Telescopes

The Astrophysical Journal Supplement Series
Lobster eye telescopes are designed to capture X-ray emissions from celestial objects across a broad field of view. However, the unique optical system of these telescopes leads to a cruciform pattern on the detector plane, complicating the detection of ...
Peng Jia, Yijun Zhang, Kaiyang Li, Yuan Liu, Haiwu Pan, Yushan Li   +5 more
doaj   +1 more source

The high energy X-ray probe (HEX-P): bringing the cosmic X-ray background into focus

Frontiers in Astronomy and Space Sciences
Since the discovery of the cosmic X-ray background (CXB), astronomers have strived to understand the accreting supermassive black holes (SMBHs) contributing to its peak in the 10–40 keV band.
F. Civano, X. Zhao, P. G. Boorman, S. Marchesi, S. Marchesi, T. Ananna, S. Creech, S. Creech, C.-T. Chen, C.-T. Chen, R. C. Hickox, D. Stern, K. Madsen, J. A. García, R. Silver, R. Silver, J. Aird, D. M. Alexander, M. Baloković, M. Baloković, W. N. Brandt, W. N. Brandt, W. N. Brandt, J. Buchner, P. Gandhi, E. Kammoun, E. Kammoun, S. LaMassa, G. Lanzuisi, A. Merloni, A. Moretti, K. Nandra, E. Nardini, A. Pizzetti, S. Puccetti, R. W. Pfeifle, R. W. Pfeifle, C. Ricci, C. Ricci, D. Spiga, N. Torres-Albà   +40 more
doaj   +1 more source