Results 71 to 80 of about 329,488 (298)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
The X-ray background and the deep X-ray surveys [PDF]
Advances in Space Research, 2004 10 pages, 4 figures. Invited review talk, to appear in New X-ray Results from Clusters of Galaxies and Black Holes (Oct 2002; Houston, TX), eds. C. Done, E.M. Puchnarewicz, M.J.
openaire +2 more sources
The HectoMAP Cluster Survey. II. X-Ray Clusters [PDF]
The Astrophysical Journal, 2018 Abstract We apply a friends-of-friends algorithm to the HectoMAP redshift survey and cross-identify associated X-ray emission in the ROSAT All-Sky Survey data (RASS). The resulting flux-limited catalog of X-ray cluster surveys is complete to a limiting flux of ∼3 × 10−13 erg s−1 cm−2 and includes 15 clusters (7 newly discovered) with ...
Jubee Sohn +7 more
openaire +4 more sources
Hard X-ray surveys and the local AGN population
, 2017 We discuss some recent achievements in our understanding of the local AGN population based on large-area hard X-ray surveys (in particular, by the IBIS instrument aboard INTEGRAL), focusing on the issue of the fraction of obscured AGN as a function of ...
Sazonov, Sergey
core +1 more source
The BMW Deep X-Ray Cluster Survey [PDF]
, 2006 3 pages, 2 figures; to appear in Proc. of the ESO/ECF/STSCI workshop on "Deep Fields", Garching Oct 2000, (Publ: Springer)
Guzzo, L. +9 more
openaire +2 more sources
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Simulating the Sensitivity to Stellar Point Sources of Chandra X-Ray Observations
The Astrophysical Journal Supplement Series, 2023 The Chandra Cygnus OB2 Legacy Survey is a wide and deep X-ray survey of the nearby and massive Cygnus OB2 association. The survey has detected ∼8000 X-ray sources, the majority of which are pre-main-sequence X-ray-emitting young stars in the association ...
Nicholas J. Wright +4 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source