Results 71 to 80 of about 7,431,143 (302)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

PEARLS: NuSTAR and XMM-Newton Extragalactic Survey of the JWST North Ecliptic Pole Time-domain Field II

The Astrophysical Journal
We present the second NuSTAR and XMM-Newton extragalactic survey of the JWST north ecliptic pole (NEP) time-domain field (TDF). The first NuSTAR NEP-TDF survey had 681 ks total exposure time executed in NuSTAR cycle 5 in 2019 and 2020. This second survey,
Xiurui Zhao, Francesca Civano, Christopher N. A. Willmer, Silvia Bonoli, Chien-Ting Chen, Samantha Creech, Renato Dupke, Francesca M. Fornasini, Rolf A. Jansen, Satoshi Kikuta, Anton M. Koekemoer, Sibasish Laha, Stefano Marchesi, Rosalia O’Brien, Ross Silver, S. P. Willner, Rogier A. Windhorst, Haojing Yan, Jailson Alcaniz, Narciso Benitez, Saulo Carneiro, Javier Cenarro, David Cristóbal-Hornillos, Alessandro Ederoclite, Antonio Hernán-Caballero, Carlos López-Sanjuan, Antonio Marín-Franch, Claudia Mendes de Oliveira, Mariano Moles, Laerte Sodré Jr., Keith Taylor, Jesús Varela, Héctor Vázquez Ramió   +32 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

X-ray detector based on a bulk micromachined photodiode combined with a scintillating crystal [PDF]

, 2003
This paper reports the design, fabrication, assembly and testing of a x-ray detector based on a bulk micromachined photodiode (BMMPD) with a cavity filled with a scintillating crystal.
Ramos, N. F., Costa, M F, Evans, A. G. R., Rocha, J G, Evans, A G R, Schabmueller, C G J, Correia, J H, Costa, Manuel F. M., Lanceros-Mendez, S, Lanceros-Méndez, S., Wolffenbuttel, R F, Rocha, J. G., Schabmueller, C. G. J., Correia, J. H., Wolffenbuttel, R. F., Ramos, N F   +15 more
core   +1 more source

EROSITA: AGN SCIENCE, BACKGROUND DETERMINATION, AND OPTICAL FOLLOW-UP SPECTROSCOPY

Acta Polytechnica, 2013
More than 20 years after the highly impacting ROSAT all-sky survey in the soft X-ray spectral range, we are close to the next major X-ray all/sky surveys with eROSITA. eROSITA will be the primary instrument on-board the Russian “Spectrum–Roentgen–Gamma” (
Thomas Boller
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Simulations of X-ray bursts and superbursts [PDF]

, 2015
Observations of neutron star in binary systems provide powerful constrains on the physics at the surface of neutron stars. During the accretion of matter from the companion star, periodic nuclear explosion are triggered in the outer layers of the neutron
Fehlmann, Sofie
core   +1 more source

XClass: An Automated Multiwavelength Machine Learning Pipeline for Classification of Extragalactic X-Ray Sources. I. Pipeline Description

The Astrophysical Journal
Most X-ray sources detected in nearby galaxies by the Chandra X-ray Observatory lack astrophysical classifications. We present XClass (X-ray Classifier for extragalactic sources), an end-to-end machine learning pipeline that classifies extragalactic X ...
Blagoy Rangelov, Nicholas Moore, Haley Dutton, Erika Marentes   +3 more
doaj   +1 more source

First X-ray detection of the symbiotic nova CN Cha with eROSITA/SRG

Astronomy & Astrophysics
Aims. We report on the first X-ray detection of the symbiotic star CN Cha with the extended Roentgen Survey with an Imaging Telescope Array (eROSITA) on board Spektrum-Roentgen Gamma (SRG). Methods.
Saeedi Sara, Merc Jaroslav, Sasaki Manami, Ducci Lorenzo, Freyberg Michael   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source