Results 31 to 40 of about 67,039 (310)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The NH Distribution of Hard X-Ray Selected Active Galactic Nuclei in the NEP Field

The Astrophysical Journal
X-ray surveys are one of the most unbiased methods for detecting Compton-thick (CT; N _H ≥ 10 ^24 cm ^−2 ) active galactic nuclei (AGN), which are thought to comprise up to 60% of AGN within z ≲ 1.0.
Samantha Creech, Francesca Civano, Daniel R. Wik, Ross Silver, Xiurui Zhao, Rafael Ortiz III, Tonima Ananna, Norman A. Grogin, Rolf Jansen, Anton M. Koekemoer, Christopher N.A. Willmer, Rogier A. Windhorst   +11 more
doaj   +1 more source

Future Perspectives for Gamma-ray Burst Detection from Space

Universe
Since their first discovery in the late 1960s, gamma-ray bursts have attracted an exponentially growing interest from the international community due to their central role in the most highly debated open questions of the modern research of astronomy ...
Enrico Bozzo, Lorenzo Amati, Wayne Baumgartner, Tzu-Ching Chang, Bertrand Cordier, Nicolas De Angelis, Akihiro Doi, Marco Feroci, Cynthia Froning, Jessica Gaskin, Adam Goldstein, Diego Götz, Jon E. Grove, Sylvain Guiriec, Margarita Hernanz, C. Michelle Hui, Peter Jenke, Daniel Kocevski, Merlin Kole, Chryssa Kouveliotou, Thomas Maccarone, Mark L. McConnell, Hideo Matsuhara, Paul O’Brien, Nicolas Produit, Paul S. Ray, Peter Roming, Andrea Santangelo, Michael Seiffert, Hui Sun, Alexander van der Horst, Peter Veres, Jianyan Wei, Nicholas White, Colleen Wilson-Hodge, Daisuke Yonetoku, Weimin Yuan, Shuang-Nan Zhang   +37 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Deep X-ray surveys [PDF]

, 2016
I will summarize the most relevant achievements of the ultra deep XMM survey in the Chandra Deep Field South and the lessons learned for the planning of future X-ray ...
COMASTRI, Andrea
core  

Luminosity Evolution of the Hot Gas in Normal Galaxies from the Near Universe to z = 0.5

The Astrophysical Journal
We explore the evolution of the ∼10 ^7 K hot gas in normal galaxies out to redshift = 0.5 (lookback time = 5 Gyr), using X-ray luminosity functions (XLFs) built from a sample of 575 normal galaxies with z < 0.6 detected in five high-galactic-latitude ...
Dong-Woo Kim, Giuseppina Fabbiano
doaj   +1 more source

The Final Season Reimagined: 30 Tidal Disruption Events from the ZTF-I Survey

The Astrophysical Journal, 2022
Tidal disruption events (TDEs) offer a unique way to study dormant black holes. While the number of observed TDEs has grown thanks to the emergence of wide-field surveys in the past few decades, questions regarding the nature of the observed optical, UV,
Erica Hammerstein, Sjoert van Velzen, Suvi Gezari, S. Bradley Cenko, Yuhan Yao, Charlotte Ward, Sara Frederick, Natalia Villanueva, Jean J. Somalwar, Matthew J. Graham, Shrinivas R. Kulkarni, Daniel Stern, Igor Andreoni, Eric C. Bellm, Richard Dekany, Suhail Dhawan, Andrew J. Drake, Christoffer Fremling, Pradip Gatkine, Steven L. Groom, Anna Y. Q. Ho, Mansi M. Kasliwal, Viraj Karambelkar, Erik C. Kool, Frank J. Masci, Michael S. Medford, Daniel A. Perley, Josiah Purdum, Jan van Roestel, Yashvi Sharma, Jesper Sollerman, Kirsty Taggart, Lin Yan   +32 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Luminosity dependent X-ray AGN clustering ? [PDF]

, 2008
We have analysed the angular clustering of X-ray selected active galactic nuclei (AGN) in different flux-limited sub-samples of the Chandra Deep Field North (CDF-N) and South (CDF-S) surveys.
Manolis Plionis
core