Results 71 to 80 of about 491,746 (343)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Contributions of X-ray CT to the characterization of natural building stones and their disintegration [PDF]

, 2010
This paper highlights the use of the high resolution scanner at the Centre for X-ray Tomography in Ghent, Belgium (UGCT), for the 3D quantitative evaluation of the disintegration of some French natural building stones.
Boone, Marijn, Boone, Matthieu, Cnudde, Veerle, De Kock, Tim, Dewanckele, Jan, Jacobs, Patric, Van Hoorebeke, Luc, Van Loo, Denis, Vlassenbroeck, Jelle   +8 more
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Inconsistent stimulation of plasma ACTH through corticotropin-releasing factor in a patient with central Cushing's disease due to pituitary adenoma [PDF]

, 1985
Three uncommon findings were observed in a case of Cushing's disease due to macroadenoma: no suppression of plasma ACTH during an 8-mg dexamethasone test, a negative corticotropin-releasing factor test, and a normal X-ray of the sella turcica.
Lüdecke, D. K., Rohrmoser, B., Scriba, Peter Christian   +2 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Inversion formulas for the broken-ray Radon transform

, 2010
We consider the inverse problem of the broken ray transform (sometimes also referred to as the V-line transform). Explicit image reconstruction formulas are derived and tested numerically.
Arridge S R, Bal G, Choulli M, John C Schotland, Lucia Florescu, Morvidone M, Stefanov P, Vadim A Markel   +7 more
core   +1 more source

A tilted grating interferometer for full vector field differential x-ray phase contrast tomography [PDF]

, 2011
We report on a setup for differential x-ray phase-contrast imaging and tomography, that measures the full 2D phase-gradient information. The setup uses a simple one-dimensional x-ray grating interferometer, in which the grating structures of the ...
David, C, Donath, T, Marone, F, Modregger, P, Pfeiffer, F, Rutishauser, S, Stampanoni, M   +6 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Doppler tomography of the transient X-ray binary Centaurus X-4 in quiescence

, 2005
We present ESO-NTT low resolution spectroscopy of the neutron star X-ray transient Cen X-4 in quiescence over a complete orbital cycle. Our data reveal the presence of a K3-7 V companion which contributes 63% to the 5600-6900A flux and orbits the neutron
Belian, Bhattacharya, Brown, Burderi, Campana, Campana, Campana, Campana, Campana, Casares, Casares, Chevalier, Cowley, Eracleous, G. L. Israel, Harlaftis, Harlaftis, Haswell, Horne, Horne, Hynes, Illarionov, J. Casares, L. Stella, Maccarone, Markwardt, Markwardt, Marsh, Martin, McClintock, McClintock, Menou, P. A. Charles, P. D'Avanzo, Rutledge, S. Campana, S. Covino, Shaham, Shahbaz, Shahbaz, Shahbaz, Steeghs, Stella, Swank, Torres, van der Klis, van Paradijs, Welsh, Wijnands, Wynn   +49 more
core   +1 more source