Results 71 to 80 of about 70,449 (261)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Compressed sensing as a tool for scanning very large objects with high energy X-ray computed tomography

, 2022
S.141-144We propose a novel high-energy X-ray Computed Tomography system for inspecting very large objects like automobiles and sea freight containers.
Dittmann, Jonas, Reims, Nils, Sukowski, Frank, Schön, Tobias, Firsching, Markus   +4 more
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Predicting dialyzer fiber blocking is hard due to high intrapatient variability and limited utility of thrombin generation markers

Scientific Reports
To date, no reliable blood-based or instrumental parameters are available to quantify dialyzer fiber blocking during hemodialysis. The only accurate method remains micro-computed tomography (µCT) imaging of the hemodialyzer post-dialysis, a labor ...
Sunny Eloot, Tom Mertens, Iván Josipovic, Joke Konings, Griet Glorieux, Laura E. Fredenburgh, Mark Roest, Rolando Acosta, Filip De Somer, Ethan P. Marin, Matthieu N. Boone, Wim Van Biesen, Floris Vanommeslaeghe   +12 more
doaj   +1 more source

Phase contrast imaging with a laboratory-based microfocus X-ray source [PDF]

, 2007
This project looks at the design of an in-line X-ray phase contrast imaging system, based around the Bede Microsource®, on a suitable scale for imaging small pathological samples. The system is applied to two test objects to assess feasibility of its use
Kelly, Kathryn L, Kelly, Kathryn L.
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

WEST tokamak hard x-ray tomography inversion

AIP Advances, 2021
Long-pulse steady-state discharges with lower hybrid current drive were successfully obtained in the limiter configuration machine, Tore Supra. The hard x-ray (HXR) diagnostic system in Tore Supra associated with tomographic inversion provided a good ...
K. Wongrach, D. Mazon, J. Morales, L. Fleury, R. Picha, J. Promping   +5 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Analysis of industrial X-ray computed tomography data with deep neural networks

, 2021
X-ray computed tomography (XCT) is increasingly utilized industrially at material- and process development as well as in non-destructive quality control; XCT is important to many emerging manufacturing technologies, for example metal additive ...
Lindgren, Erik,, Zach, Christopher, Zach, Christopher,, Lindgren, Erik   +3 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source