Results 41 to 50 of about 569,974 (248)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
X-ray variability of GRS 1915+105 during the low-hard state observed with the Indian X-ray astronomy experiment (IXAE) [PDF]
, 1997 The galactic superluminal transient X-ray source GRS 1915+105 was observed with the pointed proportional counters (PPCs) onboard the Indian satellite IRS-P3 during 1996 July 23-27.
Agrawal, P.C. +7 more
core +2 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
X-rays from Blue Compact Dwarf Galaxies
, 2011 We measured the X-ray fluxes from an optically-selected sample of blue compact dwarf galaxies (BCDs) with metallicities
Calzetti +25 more
core +1 more source
International Astronomical Union Colloquium, 1995 An X-ray burst is a sudden increase (rise time of order seconds) of the X-ray brightness of an X-ray source, which after reaching its peak decays, generally within a minute. The sky distribution of X-ray burst sources indicates that they are galactic objects (see Fig.
van Paradijs, J.A., Lewin, W.H.G.
openaire +2 more sources
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Supernova Properties from Shock Breakout X-rays
, 2004 We investigate the potential of the upcoming LOBSTER space observatory (due circa 2009) to detect soft X-ray flashes from shock breakout in supernovae, primarily from Type II events.
Andrew J. Calzavara +44 more
core +4 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source