Results 51 to 60 of about 954,200 (350)

X Chromosome of Female Cells Shows Dynamic Changes in Status during Human Somatic Cell Reprogramming

Stem Cell Reports, 2014
Induced pluripotent stem cells (iPSCs) acquire embryonic stem cell (ESC)-like epigenetic states, including the X chromosome. Previous studies reported that human iPSCs retain the inactive X chromosome of parental cells, or acquire two active X ...
Kun-Yong Kim, Eriona Hysolli, Yoshiaki Tanaka, Brandon Wang, Yong-Wook Jung, Xinghua Pan, Sherman Morton Weissman, In-Hyun Park   +7 more
doaj   +1 more source

Why does the X chromosome lag behind autosomes in GWAS findings?

PLoS Genetics, 2023
The X-chromosome is among the largest human chromosomes. It differs from autosomes by a number of important features including hemizygosity in males, an almost complete inactivation of one copy in females, and unique patterns of recombination.
Ivan P Gorlov, Christopher I Amos
doaj   +1 more source

Identification of candidate novel production variants on the Bos taurus chromosome X

Journal of Dairy Science, 2023
: Chromosome X is often excluded from bovine genetic studies due to complications caused by the sex specific nature of the chromosome. As chromosome X is the second largest cattle chromosome and makes up approximately 6% of the female genome, finding ...
H. Trebes, Y. Wang, E. Reynolds, K. Tiplady, C. Harland, T. Lopdell, T. Johnson, S. Davis, B. Harris, R. Spelman, C. Couldrey   +10 more
doaj   +1 more source

LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by the Tsc22d3 gene on the X chromosome [PDF]

, 2013
Natural variation for LPS-induced lethal inflammation in mice is useful for identifying new genes that regulate sepsis, which could form the basis for novel therapies for systemic inflammation in humans.
Beaulieu E, Carlo Riccardi, Claude Libert, Eddleston J, Filip Van Hauwermeiren, Ioanna Petta, Iris Pinheiro, Leen Puimège, Lien Dejager, Marlies Ballegeer, Marnik Vuylsteke, Sofie Vandevyver, Tina Mahieu   +12 more
core   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Association of Human iPSC Gene Signatures and X Chromosome Dosage with Two Distinct Cardiac Differentiation Trajectories. [PDF]

, 2019
Despite the importance of understanding how variability across induced pluripotent stem cell (iPSC) lines due to non-genetic factors (clone and passage) influences their differentiation outcome, large-scale studies capable of addressing this question ...
Banovich, Bao, Barakat, Bargehr, Bruck, Burridge, D'Antonio, DeBoever, Desai, Diogenes, Dubois, Gittenberger-de Groot, GTEx Consortium, Guadix, Iyer, Kilpinen, Kim, Li, Lian, Lian, Luo, Mo, Newman, Paik, Panopoulos, Panopoulos, Perez-Pomares, Strober, Subramanian, Tatler, Tohyama, Tukiainen, Wang, Witty, Zhao   +34 more
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

X Chromosome Pericentric Inversion: Report of a Case with 46,X,inv(X)(p11.2q26) and a Mini-Review of the Literature

Gazi Medical Journal
Pericentric inversions arise from double breaks on opposite arms of the chromosome, followed by 180° rotation and reintegration of the broken segment. Carriers of an inversion are mostly phenotypically healthy.
Emine Göktaş, Betül Okur Altındaş, Ayşe Gül Zamani, Mahmut Selman Yıldırım   +3 more
doaj   +1 more source

The probability to initiate X chromosome inactivation is determined by the X to autosomal ratio and X chromosome specific allelic properties.

PLoS ONE, 2009
BackgroundIn female mammalian cells, random X chromosome inactivation (XCI) equalizes the dosage of X-encoded gene products to that in male cells. XCI is a stochastic process, in which each X chromosome has a probability to be inactivated. To obtain more
Kim Monkhorst, Bas de Hoon, Iris Jonkers, Eskeatnaf Mulugeta Achame, Wouter Monkhorst, Jos Hoogerbrugge, Eveline Rentmeester, Hans V Westerhoff, Frank Grosveld, J Anton Grootegoed, Joost Gribnau   +10 more
doaj   +1 more source

Relation between mutation yield and cell lethality over a wide range of X-ray and fission neutron doses in maize [PDF]

, 1973
Dry maize seeds, of a genetic stock heterozygous for the yellow-green locus (Yg^ Λ ^ ) ι were irradiated with fission neutron doses up to 2700 rads and with 250 kVp X-rays to 40 000 rads.
Kellerer, Albrecht M., Rossi, H. H., Smith, H. H.   +2 more
core   +1 more source