Results 31 to 40 of about 954,200 (350)

Complex Evolutionary History of the Y Chromosome in Flies of the Drosophila obscura Species Group. [PDF]

, 2020
The Drosophila obscura species group shows dramatic variation in karyotype, including transitions among sex chromosomes. Members of the affinis and pseudoobscura subgroups contain a neo-X chromosome (a fusion of the X with an autosome), and ancestral Y ...
Bachtrog, Doris, Bracewell, Ryan
core  

X chromosome control of meiotic chromosome synapsis in mouse inter-subspecific hybrids. [PDF]

PLoS Genetics, 2014
Hybrid sterility (HS) belongs to reproductive isolation barriers that safeguard the integrity of species in statu nascendi. Although hybrid sterility occurs almost universally among animal and plant species, most of our current knowledge comes from the ...
Tanmoy Bhattacharyya, Radka Reifova, Sona Gregorova, Petr Simecek, Vaclav Gergelits, Martin Mistrik, Iva Martincova, Jaroslav Pialek, Jiri Forejt   +8 more
doaj   +1 more source

The Origin of a New Sex Chromosome by Introgression between Two Stickleback Fishes. [PDF]

, 2019
Introgression is increasingly recognized as a source of genetic diversity that fuels adaptation. Its role in the evolution of sex chromosomes, however, is not well known. Here, we confirm the hypothesis that the Y chromosome in the ninespine stickleback,
Abbott, Alexander, Anders, Bachtrog, Bachtrog, Bachtrog, Bronson, Browning, Carling, Carneiro, Charlesworth, Charlesworth, Choi, Cook, Corcoran, Coyne, Coyne, Danecek, DePristo, Edwards, Glazer, Green, Groves Dixon, Hagen, Irwin, Ishikawa, JanouŠek, Jay, Jombart, Jombart, Jun Kitano, Krueger, Langmead, Li, Li, Lindholm, Love, Luo, Mark Kirkpatrick, Martin, Martin, Martin, Meguro, Melissa Wilson Sayres, Muirhead, Natri, Neafsey, Nei, O’Neill, Payseur, Petit, Presgraves, Quinlan, Ravinet, Ross, Saetre, Sankararaman, Schwander, Sciuchetti, Smit, Stamatakis, Storchová, Stölting, Sun, Takahashi, Takahashi, Toews, Tosi, Toups, Tuttle, van Doorn, Vicoso, von Hippel, Wang, White, Yang, Yoshida, Yoshida, Úbeda   +78 more
core   +1 more source

X chromosome and suicide [PDF]

Molecular Psychiatry, 2009
Suicide completion rates are significantly higher in males than females in most societies. Although gender differences in suicide rates have been partially explained by environmental and behavioral factors, it is possible that genetic factors, through differential expression between genders, may also help explain gender moderation of suicide risk. This
L M, Fiori, H, Zouk, C, Himmelman, G, Turecki   +3 more
openaire   +2 more sources

Massive gene amplification on a recently formed Drosophila Y chromosome. [PDF]

, 2019
Widespread loss of genes on the Y is considered a hallmark of sex chromosome differentiation. Here we show that the initial stages of Y evolution are driven by massive amplification of distinct classes of genes. The neo-Y chromosome of Drosophila miranda
Bachtrog, Doris, Bracewell, Ryan, Mahajan, Shivani   +2 more
core   +1 more source

Global analysis of X-chromosome dosage compensation

Journal of Biology, 2006
Background Drosophila melanogaster females have two X chromosomes and two autosome sets (XX;AA), while males have a single X chromosome and two autosome sets (X;AA).
Malley James D, Dudko Olga K, Doctolero Michael, Nuttall Rachel, Sturgill David, Parisi Michael, Gupta Vaijayanti, Eastman P Scott, Oliver Brian   +8 more
doaj   +1 more source

Artificial escape from XCI by DNA methylation editing of the CDKL5 gene. [PDF]

, 2020
A significant number of X-linked genes escape from X chromosome inactivation and are associated with a distinct epigenetic signature. One epigenetic modification that strongly correlates with X-escape is reduced DNA methylation in promoter regions. Here,
Anderson, Johnathon D, Buchanan, Fiona KB, Cameron, David, Carter, Jasmine L, Coggins, Nicole B, Deng, Peter, Fink, Kyle D, Gonzalez, Casiana E, Halmai, Julian ANM, Halmai, Julian ANM, Lock, Samantha R, Nolta, Jan, O'Geen, Henriette, Segal, David J, Waldo, Jennifer J   +14 more
core   +1 more source

Stochastic gene expression and chromosome interactions in protecting the human active X from silencing by XIST

Nucleus, 2021
Mammals use X chromosome inactivation to compensate for the sex difference in numbers of X chromosomes. A relatively unexplored question is how the active X is protected from inactivation by its own XIST gene, the long non-coding RNA, which initiates ...
Barbara R. Migeon
doaj   +1 more source

Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome. [PDF]

, 2016
The loss-of-function mutations of serine protease inhibitor, Kazal type 1 (SPINK1) gene are associated with human chronic pancreatitis, but the underlying mechanisms remain unknown. We previously reported that mice lacking Spink3, the murine homologue of
Araki, Kimi, Baba, Hideo, Gukovskaya, Anna S, Gukovsky, Ilya, Hashimoto, Daisuke, Komazawa-Sakon, Sachiko, Lee, Grace E, Murai, Shin, Nakano, Hiroyasu, Nishina, Takashi, Notohara, Kenji, Ohmuraya, Masaki, Sakata, Kazuya, Suzuki, Chigure, Uchiyama, Yasuo, Yamamura, Ken-Ichi   +15 more
core   +2 more sources

Rapid generation of chromosome-specific alphoid DNA probes using the polymerase chain reaction [PDF]

, 1992
Non-isotopic in situ hybridization of chromosome-specific alphoid DNA probes has become a potent tool in the study of numerical aberrations of specific human chromosomes at all stages of the cell cycle. In this paper, we describe approaches for the rapid
A Gnirke, AHN Hopman, AR Mitchell, C Huxley, C Lengauer, Christoph Lengauer, D Pinkel, ED Green, EW Jabs, HF Willard, HF Willard, HF Willard, HM Rosenberg, Ian Dunham, J Anastasi, J Meyne, JE Koch, JS Waye, JS Waye, JS Waye, L Manuelidis, L Manuelidis, M Klever, P Emmerich, PJ Poddighe, PR Langer, S Popp, T Cremer, T Cremer, T Cremer, T Imai, T Maniatis, Terry Featherstone, Thomas Cremer   +33 more
core   +1 more source