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Association of X Chromosome Aberrations with Male Infertility
Acta Medica Bulgarica, 2021 Male infertility is caused by spermatogenetic failure, clinically noted as oligoor azoospermia. Approximately 20% of infertile patients carry a genetic defect.
Xharra S. +5 more
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Biophysics and Physicobiology, 2022 X chromosome inactivation center (Xic) pairing occurs during the differentiation of embryonic stem (ES) cells from female mouse embryos, and is related to X chromosome inactivation, the circadian clock, intra-nucleus architecture, and metabolism. However,
Tetsushi Komoto +2 more
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Monosomy for the X chromosome [PDF]
Chromosome Research, 2009 Dosage compensation serves to equalize X chromosome gene expression in mammalian males and females and involves extensive silencing of the 2nd X chromosome in females. If dosage compensation mechanisms completely suppressed the 2nd X chromosome, then actual physical loss of this "eXtra" chromosome should have few consequences.
Carolyn A, Bondy, Clara, Cheng
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A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila [PDF]
, 2008 Population genetics models show that, under certain conditions, the X chromosome is expected to be under more efficient selection than the autosomes.
Vicoso, Beatriz +2 more
core +4 more sources
G3: Genes, Genomes, Genetics, 2020 Mouse sex chromosomes are enriched for co-amplified gene families, present in tens to hundreds of copies. Co-amplification of Slx/Slxl1 on the X chromosome and Sly on the Y chromosome are involved in dose-dependent meiotic drive, however the role of ...
Martin F. Arlt +4 more
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Association of Parental Origin with Clinical Profile in Klinefelter Syndrome [PDF]
Journal of Clinical and Diagnostic Research, 2015 Introduction: Several genomic imprinting mechanisms have been postulated to report the parent-of-origin in Klinefelter syndrome. It was stated in the literature, parental origin has an effect on behavioral phenotype of Klinefelter individuals, but the
Ranganath Vallabhajosyula +2 more
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Analysis of non-Hodgkin's lymphoma by conventional cytogenetics and fluorescence in-situ hybridisation. [PDF]
, 1995 Cytogenetic analysis was performed on 40 non-Hodgkin's lymphoma (NHQ node biopsies. Chromosomes X, 3 and 12 were the most frequently gained; of the much rarer monosomies, loss of chromosome 13 was most common.
Hammond, David William
core +6 more sources
X-Chromosome Inactivation [PDF]
Current Biology, 1994 In female mammals, all X chromosomes except one are transcriptionally inactivated early in embryonic development. This is known as X-chromosome inactivation and is a form of dosage compensation, giving equal dosage of the products of X-linked genes in males and females. The mechanism is of considerable interest as an example of differential behavior of
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Mechanics and dynamics of X-chromosome pairing at X inactivation [PDF]
, 2008 At the onset of X-chromosome inactivation, the vital process whereby female mammalian cells equalize X products with respect to males, the X chromosomes are colocalized along their Xic (X-inactivation center) regions. The mechanism inducing recognition
Scialdone, Antonio +4 more
core +2 more sources
Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals
Genome Biology, 2021 Background Precise gene dosage of the X chromosomes is critical for normal development and cellular function. In mice, XX female somatic cells show transcriptional X chromosome upregulation of their single active X chromosome, while the other X ...
Irene Talon +13 more
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