Results 21 to 30 of about 568,444 (262)

Global analysis of X-chromosome dosage compensation

Journal of Biology, 2006
Background Drosophila melanogaster females have two X chromosomes and two autosome sets (XX;AA), while males have a single X chromosome and two autosome sets (X;AA).
Malley James D, Dudko Olga K, Doctolero Michael, Nuttall Rachel, Sturgill David, Parisi Michael, Gupta Vaijayanti, Eastman P Scott, Oliver Brian   +8 more
doaj   +1 more source

Detectable chromosome X mosaicism in males is rarely tolerated in peripheral leukocytes

Scientific Reports, 2021
Age-related male Y and female X chromosome mosaicism is commonly observed in large population-based studies. To investigate the frequency of male X chromosome mosaicism, we scanned for deviations in chromosome X genotyping array intensity data in a ...
Weiyin Zhou, Shu-Hong Lin, Sairah M. Khan, Meredith Yeager, Stephen J. Chanock, Mitchell J. Machiela   +5 more
doaj   +1 more source

Variation of autosomes and X chromosome STR in breast cancer and gynecological cancer tissues

Open Life Sciences, 2017
This study analyses 1000 cases of patients with breast cancer and 2000 cases of patients with gynecological cancer (1000 cases of malignant tumor, 1000 cases of benign tumors), where breast cancer and malignant tumor patients comprise the observation ...
Hou Youxiang, Dong Zhanfei, Kuerban Gulina   +2 more
doaj   +1 more source

Large-Scale Analysis of X Inactivation Variations between Primed and Naïve Human Embryonic Stem Cells

Cells, 2022
X chromosome inactivation is a mammalian dosage compensation mechanism, where one of two X chromosomes is randomly inactivated in female cells. Previous studies have suggested that primed human embryonic stem cells (hESCs) maintain an eroded state of the
Roni Sarel-Gallily, Nissim Benvenisty
doaj   +1 more source

X chromosome control of meiotic chromosome synapsis in mouse inter-subspecific hybrids. [PDF]

PLoS Genetics, 2014
Hybrid sterility (HS) belongs to reproductive isolation barriers that safeguard the integrity of species in statu nascendi. Although hybrid sterility occurs almost universally among animal and plant species, most of our current knowledge comes from the ...
Tanmoy Bhattacharyya, Radka Reifova, Sona Gregorova, Petr Simecek, Vaclav Gergelits, Martin Mistrik, Iva Martincova, Jaroslav Pialek, Jiri Forejt   +8 more
doaj   +1 more source

Stochastic gene expression and chromosome interactions in protecting the human active X from silencing by XIST

Nucleus, 2021
Mammals use X chromosome inactivation to compensate for the sex difference in numbers of X chromosomes. A relatively unexplored question is how the active X is protected from inactivation by its own XIST gene, the long non-coding RNA, which initiates ...
Barbara R. Migeon
doaj   +1 more source

Escapees on the X chromosome [PDF]

Proceedings of the National Academy of Sciences, 1999
In many organisms, differentiation of the sex chromosome complement resulted in the coordinated regulation of genes on whole chromosomes to equalize gene expression between the sexes. In mammals, X inactivation evolved to restore equal expression of X-linked genes in males and females (1).
openaire   +2 more sources

Mosaicism for r(X) and der(X)del(X)(p11.23)dup(X)(p11.21p11.22) provides insight into the possible mechanism of rearrangement

Molecular Cytogenetics, 2008
We report a patient with a unique and complex cytogenetic abnormality involving mosaicism for a small ring X and deleted Xp derivative chromosome with tandem duplication at the break point. The patient presented with failure to thrive, muscular hypotonia,
Fang Ping, Brown Chester W, Yatsenko Svetlana A, Peacock Sandra, Ou Zhishuo, Cooper M Lance, Shchelochkov Oleg A, Stankiewicz Pawel, Cheung Sau   +8 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Elastic dosage compensation by X-chromosome upregulation

Nature Communications, 2022
The concerted dynamics of X-chromosome upregulation and X-chromosome inactivation, which collectively balance X-chromosome expression, are not well understood.
Antonio Lentini, Huaitao Cheng, J. C. Noble, Natali Papanicolaou, Christos Coucoravas, Nathanael Andrews, Qiaolin Deng, Martin Enge, Björn Reinius   +8 more
doaj   +1 more source