Results 61 to 70 of about 964,345 (336)

Identification of candidate novel production variants on the Bos taurus chromosome X

Journal of Dairy Science, 2023
: Chromosome X is often excluded from bovine genetic studies due to complications caused by the sex specific nature of the chromosome. As chromosome X is the second largest cattle chromosome and makes up approximately 6% of the female genome, finding ...
H. Trebes, Y. Wang, E. Reynolds, K. Tiplady, C. Harland, T. Lopdell, T. Johnson, S. Davis, B. Harris, R. Spelman, C. Couldrey   +10 more
doaj   +1 more source

Automated clinical system for chromosome analysis [PDF]

, 1978
An automatic chromosome analysis system is provided wherein a suitably prepared slide with chromosome spreads thereon is placed on the stage of an automated microscope.
Castleman, K. R., Friedan, H. J., Johnson, E. T., Rennie, P. A., Wall, R. J.   +4 more
core   +1 more source

Specific staining of human chromosomes in Chinese hamster x man hybrid cell lines demonstrates interphase chromosome territories [PDF]

, 1985
In spite of Carl Rabl's (1885) and Theodor Boveri's (1909) early hypothesis that chromosomes occupy discrete territories or domains within the interphase nucleus, evidence in favor pf this hypothesis has been limited and indirect so far in higher plants ...
AB Murray, C Rabl, C Zorn, DA Agard, DE Comings, DE Comings, DJ DuPraw, E Therman, F Vogel, GA Rappold, GA Rappold, J Hozier, J Sedat, JJ Leary, JS Lebkowski, JT Finch, JW Littlefield, K Grell, K Sperling, L Avivi, L Hens, L Manuelidis, L Manuelidis, LM Kunkel, M Feldman, M Raith, MD Bennett, PR Langer, PR Langer-Safer, R Hancock, S Wischnitzer, SM Stack, T Cremer, T Cremer, Th Boveri   +34 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Dicentric human X chromosomes [PDF]

Hereditas, 2009
Cytological findings in 5 individuals with structurally abnormal X chromosomes are presented. Of 4 patients with an i(Xq) chromosome, 2 had an apparently dicentric, and 2 an apparently monocentric isochromosome. The former type of chromosome had twice as much centric heterochromatin (2 distinct C-bands) as the latter.
A, De la Chapelle, K, Stenstrand
openaire   +2 more sources

Mismatches between the genetic and phenotypic sex in the wild Kou population of Nile tilapia Oreochromis niloticus [PDF]

, 2019
Sex determination and sex chromosomes can be very diverse between teleost species. The group of tilapias shows a polymorphism in sex determination not only between closely related species but also between domestic strains within a species.
Baroiller, Jean-François, D'Cotta, Helena, Sissao, Rokyatou, Toguyeni, Aboubacar   +3 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Amplification of the androgen receptor may not explain the development of androgen-independent prostate cancer [PDF]

, 2001
Objective To examine the role of androgen receptor (AR) gene amplification and aneusomy of the X chromosome in the development of antiandrogen-resistant prostate cancer.
Bartlett, J.M.S., Edwards, J., Krishna, N.S., Mukherjee, R., Underwood, M.A., Watters, A.D.   +5 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

https://www.emjreviews.com/allergy-immuThe 'Nucleolus' Hypothesis of Autoimmune Diseases and Its Implications

European Medical Journal, 2017
Many autoimmune diseases, such as lupus and Sjögren’s syndrome, have a female bias and adult onset. One possible explanation for this bias is disruption of the inactive X chromosome, which is a major epigenetic feature in female cells. Indeed, only one X
Wesley H. Brooks, Yves Renaudineau
doaj