Results 71 to 80 of about 6,270,911 (362)

Inversions are bigger on the X chromosome [PDF]

Molecular Ecology, 2018
AbstractIn many insects, X‐linked inversions fix at a higher rate and are much less polymorphic than autosomal inversions. Here, we report that in Drosophila, X‐linked inversions also capture 67% more genes. We estimated the number of genes captured through an approximate Bayesian computational analysis of gene orders in nine species of Drosophila.
Changde Cheng, Mark Kirkpatrick
openaire   +4 more sources

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Using sequencing coverage statistics to identify sex chromosomes in minke whales [PDF]

arXiv, 2019
The ever-increasing number of genome sequencing and resequencing projects is a central source of insights into the ecology and evolution of non-model organisms. An important aspect of genomics is the elucidation of sex determination systems and identifying genes on sex chromosomes.
arxiv  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Accelerated adaptive evolution on a newly formed X chromosome.

PLoS Biology, 2009
Sex chromosomes originated from ordinary autosomes, and their evolution is characterized by continuous gene loss from the ancestral Y chromosome. Here, we document a new feature of sex chromosome evolution: bursts of adaptive fixations on a newly formed ...
Doris Bachtrog, Jeffrey D Jensen, Zhi Zhang   +2 more
doaj   +1 more source

The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer

Genome Research, 2015
Disappearance of the Barr body is considered a hallmark of cancer, although whether this corresponds to genetic loss or to epigenetic instability and transcriptional reactivation is unclear.
R. Chaligné, T. Popova, M. Mendoza-Parra, Mohamed-Ashick M. Saleem, D. Gentien, Kristen Ban, T. Piolot, O. Leroy, O. Mariani, H. Gronemeyer, A. Vincent-Salomon, M. Stern, E. Heard   +12 more
semanticscholar   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Amenorréia e anormalidades do cromossomo X Amenorrhea and X chromosome abnormalities

Revista Brasileira de Ginecologia e Obstetrícia, 2008
OBJETIVO: correlacionar as manifestações clínicas de pacientes com amenorréia e anormalidades do cromossomo X. MÉTODOS: realizou-se uma análise retrospectiva dos achados clínicos e laboratoriais das pacientes com amenorréia e anormalidades do cromossomo ...
Rafael Fabiano Machado Rosa, Raquel Papandreus Dibi, Jamile dos Santos Picetti, Rosana Cardoso Manique Rosa, Paulo Ricardo Gazzola Zen, Carla Graziadio, Giorgio Adriano Paskulin   +6 more
doaj   +1 more source

Clustering of SNPs along a chromosome: can the neutral model be rejected? [PDF]

arXiv, 2002
Single nucleotide polymorphisms (SNPs) often appear in clusters along the length of a chromosome. This is due to variation in local coalescent times caused by,for example, selection or recombination. Here we investigate whether recombination alone (within a neutral model) can cause statistically significant SNP clustering.
arxiv  

Impact of the X Chromosome and sex on regulatory variation

bioRxiv, 2015
The X chromosome, with its unique mode of inheritance, contributes to differences between the sexes at a molecular level, including sex-specific gene expression and sex-specific impact of genetic variation.
Kimberly R. Kukurba, P. Parsana, Brunilda Balliu, Kevin S. Smith, Zachary Zappala, David A. Knowles, M. Favé, Joe R. Davis, Xin Li, Xiaowei Zhu, J. Potash, M. Weissman, Jianxin Shi, Anshul Kundaje, D. Levinson, P. Awadalla, S. Mostafavi, A. Battle, S. Montgomery   +18 more
semanticscholar   +1 more source