Results 121 to 130 of about 317,261 (329)

Perturbed maintenance of transcriptional repression on the inactive X-chromosome in the mouse brain after Xist deletion

Epigenetics & Chromatin, 2018
Background The long noncoding RNA Xist is critical for initiation and establishment of X-chromosome inactivation during embryogenesis in mammals, but it is unclear whether its continued expression is required for maintaining X-inactivation in vivo ...
Robin L. Adrianse, Kaleb Smith, Tonibelle Gatbonton-Schwager, Smitha P. Sripathy, Uyen Lao, Eric J. Foss, Ruben G. Boers, Joachim B. Boers, Joost Gribnau, Antonio Bedalov   +9 more
doaj   +1 more source

X-chromosome inactivation mosaicism in the three germ layers and the germ line of the mouse embryo [PDF]

, 1982
Electrophoretic variant forms of the X-linked enzyme phosphoglycerate kinase (PGK-1, E.C.2, 7, 2, 3) have been used to examine X-chromosome mosaicism in tissues from 121/2-day post coitum heterozygous female mouse embryos.
Fosten, M., McMahon, A., Monk, M.
core  

Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome. [PDF]

, 2016
The loss-of-function mutations of serine protease inhibitor, Kazal type 1 (SPINK1) gene are associated with human chronic pancreatitis, but the underlying mechanisms remain unknown. We previously reported that mice lacking Spink3, the murine homologue of
Araki, Kimi, Baba, Hideo, Gukovskaya, Anna S, Gukovsky, Ilya, Hashimoto, Daisuke, Komazawa-Sakon, Sachiko, Lee, Grace E, Murai, Shin, Nakano, Hiroyasu, Nishina, Takashi, Notohara, Kenji, Ohmuraya, Masaki, Sakata, Kazuya, Suzuki, Chigure, Uchiyama, Yasuo, Yamamura, Ken-Ichi   +15 more
core   +2 more sources

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

X chromosome-encoded microRNAs in immune regulation: sex differences and clinical implications

Frontiers in Global Women's Health
Sex-based differences in immune function influence susceptibility to infections and predisposition to autoimmunity, with women showing both stronger immune responses and a higher burden of autoimmune and chronic inflammatory diseases.
Valeria Lodde, Valentina Margarita, Myriam Gorospe, Ilaria Campesi   +3 more
doaj   +1 more source

Synergism of Xist Rna, DNA Methylation, and Histone Hypoacetylation in Maintaining X Chromosome Inactivation

Journal of Cell Biology, 2001
Xist RNA expression, methylation of CpG islands, and hypoacetylation of histone H4 are distinguishing features of inactive X chromatin. Here, we show that these silencing mechanisms act synergistically to maintain the inactive state.
G. Csankovszki, A. Nagy, R. Jaenisch
semanticscholar   +1 more source

Analysis of X chromosome inactivation in autism spectrum disorders. [PDF]

, 2008
International audienceAutism spectrum disorders (ASD) are complex genetic disorders more frequently observed in males. Skewed X chromosome inactivation (XCI) is observed in heterozygous females carrying gene mutations involved in several X-linked ...
Anckarsäter, Henrik, Bacchelli, Elena, Battaglia, Agatino, Betancur, Catalina, Blasi, Francesca, Botros, Hany Goubran, Bourgeron, Thomas, Carone, Simona, Chaste, Pauline, Delorme, Richard, Durand, Christelle M., Fauchereau, Fabien, Gillberg, Christopher, Gillberg, I. Carina, Gong, Xiaohong, Green, Jonathan, Jarvela, Irma, Lamb, Janine, Leboyer, Marion, Maestrini, Elena, Moreno-De-Luca, Daniel, Mouren-Simeoni, Marie Christine, Nummela, Ilona, Nygren, Gudrun, Rastam, Maria, Rossi, Mari, Toma, Claudio   +26 more
core   +4 more sources

Coordination of Cyanobacterial Nitrate Assimilation and Photosynthesis by a Novel PsbO‐Interacting Protein PirN

Advanced Science, EarlyView.
PirN was identified as a previously uncharacterized PsbO‐interacting protein specifically induced in nitrate‐grown cyanobacteria. Loss of PirN leads to coordinated downregulation of PsbO and the nitrate reductase NarB, causing decreased PSII activity and impaired growth under nitrate conditions. Complementation with either PsbO or NarB largely restores
Chengcheng Huang, Zhen Xiao, Haitao Ge, Gaojie Wang, Jinghui Dong, Yan Wang, Hang Yang, Xing Wang, Hui Gao, Zhongshu Wang, Huanling Yang, Yuanya Zhang, Xiahe Huang, Wu Xu, Weimin Ma, Wenqiang Yang, Yingchun Wang   +16 more
wiley   +1 more source

X-autosome and X-Y translocations in female carriers: X-chromosome inactivation easily detectable by 5-ethynyl-2-deoxyuridine (EdU)

Balkan Journal of Medical Genetics, 2017
Here we report one new case each of an X-autosome translocation (maternally derived), and an X-Y-chromosome translocation. Besides characterizing the involved breakpoints and/or imbalances in detail by molecular cyto-genetics, also skewed X-chromosome ...
Donat M, Louis A, Kreskowski K, Ziegler M, Weise A, Schreyer I, Liehr T   +6 more
doaj   +1 more source

Data for identification of porcine X-chromosome inactivation center, XIC, by genomic comparison with human and mouse XIC

Data in Brief, 2015
The data included in this article shows homologies of genes in porcine X-chromosome inactivation center, XIC, to each orthologue in human and mouse XIC.
Jae Yeon Hwang, Kwang-Hwan Choi, Chang-Kyu Lee   +2 more
doaj   +1 more source