Results 121 to 130 of about 92,054 (252)

Xist RNA dependent and independent mechanisms regulate dynamic X chromosome inactivation in B lymphocytes. [PDF]

Cell Rep
Toothacre NE, Rodríguez-Acevedo KL, Wiggins KJ, Scharer CD, Anguera MC.   +4 more
europepmc   +1 more source

Histological Analysis of Cryopreserved Venous Allografts Used for Liver Transplantation and Hepato‐Biliary‐Pancreatic Surgery

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Cryopreserved venous allografts, which we pioneered in 1999 for use in living donor liver transplantation and hepato‐biliary‐pancreatic surgery, are widely used and are believed to preserve vascular architecture with minimal anticoagulation or immunosuppression requirements and patency comparable to autologous grafts.
Yusuke Seki, Akihiko Ichida, Sumihito Tamura, Mariko Tanaka, Yoshinori Inagaki, Kyoji Ito, Rihito Nagata, Takuya Hashimoto, Nobuhisa Akamatsu, Tetsuo Ushiku, Kiyoshi Hasegawa   +10 more
wiley   +1 more source

SETDB1 and HUSH modulate Xist RNA levels during establishment of X chromosome inactivation. [PDF]

Nat Commun
Almeida M, Wei G, Cawte AD, Nesterova TB, Brockdorff N.   +4 more
europepmc   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Structural Variation Sequencing of 26 Amniotic Fluid Samples With Partial Gene Duplications and Postnatal Follow‐Up of the Fetuses

Prenatal Diagnosis, EarlyView.
ABSTRACT Objectives Partial gene duplications (PGDups) are a significant contributor to genetic disease. The precise genomic location and structure of PGDups are often unresolved using conventional methods, so prenatal diagnosis for PGDups is challenging, especially without ultrasound abnormalities.
Shengfang Qin, Xueyan Wang, Mengjia Yan, Yuxia He, Zhuo Zhang, Yan Yin, Jin Wang, Beibei Guo, Jing Wang, Na Xi, Zhaokai Li   +10 more
wiley   +1 more source

FGF4 initiates X-chromosome inactivation via activating YY1 and prompting loss of pluripotency factors. [PDF]

EMBO J
Ma L, Fu W, An L, Yang Q, Hai R, Xi G, Wang Y, Liu J, Zhang C, Fu Y, Zhang Z, Wang X, Tian J.   +12 more
europepmc   +1 more source

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

Phytotherapy Research, EarlyView.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan, Junhui Li, Yu Qiao, Yuwen Zhong, Xuecheng Ge, Yaoshuai Zhang, Zishu Wang, Feng Qian, Weixin Ren   +8 more
wiley   +1 more source

Integrative Bioinformatics Analyses Reveal X Chromosome Inactivation Escape Genes Dosage Dysregulation Is the Primary Contributor to Turner Syndrome. [PDF]

Iran J Biotechnol
Liang H, Li Z, Zhang F.
europepmc   +1 more source

DOM: Dual Optical Mapping Integrating Sequence‐Specific Barcodes and A/T Density Profiles

Small Methods, EarlyView.
Dual Optical Mapping (DOM) combines sequence‐specific barcodes and an A/T profile to generate complementary genomic signatures along single DNA molecules. The integration of sparse and dense mapping information enables accurate and confident genome mapping, facilitating reliable localization of long DNA molecules in complex genomes, including the ...
Jaeyoung Bae, Yunchul Kim, Joohee Choe, Jinhui Hong, Byoungsang Lee, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama, Seonghyun Lee, Jung Heon Lee, Kyubong Jo   +10 more
wiley   +1 more source

Clinical relevant Bruton's X-linked tyrosine kinase deficiency in a female with extreme X-chromosome inactivation. [PDF]

Allergy Asthma Clin Immunol
NoorSaeed SM, Alrafiaah AS, Alghamdi M, Shapiro AJ, McCusker C.   +4 more
europepmc   +1 more source