Results 271 to 280 of about 196,851 (322)

Teleost‐specific ictacalcins exhibit similar structural organization, cation‐dependent activation, and transcriptional regulation as human S100 proteins

The FEBS Journal, EarlyView.
Calcium‐binding S100 proteins are important mediators of inflammation in humans. Distant members of this family have been recently discovered in teleost fish but their resemblance to human proteins has not been explored yet. This study demonstrates that zebrafish‐specific S100i1 and S100i2 (ictacalcins) possess identical structural organization and ...
Liz Hernández, Théo Paris, Maria Demou, Catherine Birck, Christina Begon‐Pescia, Juan Francisco Rodríguez Vidal, Sylwia D. Tyrkalska, Charlotte Bureau, Catherine Gonzalez, Juliette Gracia, Etienne Lelièvre, Victoriano Mulero, Mai Nguyen‐Chi, Laure Yatime   +13 more
wiley   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

2D structure determination of a region from Xist RNA involved in X chromosome inactivation called the A-repeats region and identification of its protein partners having a structural or functional role in X inactivation

, 2009
Sylvain Maenner
openalex   +1 more source

Molecular Testing in Sickle Cell Disease: From Newborn Screening to Transfusion Care

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Sickle cell disease (SCD) is one of the most frequent monogenic diseases worldwide and a highly heterogeneous and complex disease. SCD care carries several challenges. This includes early and accurate diagnosis as well as optimal red blood cell transfusion matching in this population carrying a high risk of alloimmunization.
Thomas Pincez, Yves D. Pastore
wiley   +1 more source

Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues. [PDF]

Cell Genom
Tomofuji Y, Edahiro R, Sonehara K, Shirai Y, Kock KH, Wang QS, Namba S, Moody J, Ando Y, Suzuki A, Yata T, Ogawa K, Naito T, Namkoong H, Xuan Lin QX, Buyamin EV, Tan LM, Sonthalia R, Han KY, Tanaka H, Lee H, Asian Immune Diversity Atlas (AIDA) Network, Japan COVID-19 Task Force, Biobank Japan Project, Okuno T, Liu B, Matsuda K, Fukunaga K, Mochizuki H, Park WY, Yamamoto K, Hon CC, Shin JW, Prabhakar S, Kumanogoh A, Okada Y.   +35 more
europepmc   +1 more source

A female patient carrying a novel DMD mutation with non-random X-chromosome inactivation from a DMD family. [PDF]

BMC Med Genomics
Sun MX, Jing M, Hua Y, Wang JB, Wang SQ, Chen LL, Ju L, Liu YS.   +7 more
europepmc   +1 more source

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Regulation of X-chromosome inactivation by the X-inactivation centre

Nature Reviews Genetics, 2011
X-chromosome inactivation (XCI) ensures dosage compensation in mammals and is a paradigm for allele-specific gene expression on a chromosome-wide scale. Important insights have been made into the developmental dynamics of this process. Recent studies have identified several cis- and trans-acting factors that regulate the initiation of XCI via the X ...
Sandrine Augui, E. Nora, E. Heard
semanticscholar   +3 more sources

X-Chromosome Inactivation

2013
The dimorphism of the sex chromosomes has led to some of the most dramatic epigenetic phenomena known in order to achieve dosage compensation between the sexes. Mammalian X-chromosome inactivation (XCI) requires the differential treatment of two essentially identical chromosomes in the same nuclear environment.
Wendy P. Robinson, Allison M. Cotton, Maria S. Peñaherrera, Samantha B. Peeters, Carolyn J. Brown   +4 more
openaire   +2 more sources

Mammalian X Chromosome Inactivation

1992
The initial step in mammalian sexual differentiation is based on the XX: XY chromosomal system. In order to function properly, this chromosomal mechanism must be regulated to eliminate the aneuploidy effects in somatic tissues and still insure normal sexual differentiation and development.
S M, Gartler, K A, Dyer, M A, Goldman
openaire   +2 more sources