Results 71 to 80 of about 92,054 (252)

Perturbed maintenance of transcriptional repression on the inactive X-chromosome in the mouse brain after Xist deletion

Epigenetics & Chromatin, 2018
Background The long noncoding RNA Xist is critical for initiation and establishment of X-chromosome inactivation during embryogenesis in mammals, but it is unclear whether its continued expression is required for maintaining X-inactivation in vivo ...
Robin L. Adrianse, Kaleb Smith, Tonibelle Gatbonton-Schwager, Smitha P. Sripathy, Uyen Lao, Eric J. Foss, Ruben G. Boers, Joachim B. Boers, Joost Gribnau, Antonio Bedalov   +9 more
doaj   +1 more source

Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression

Advanced Science, EarlyView.
Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu, Yalin Liu, Rongyi Wang, Wenwen Xu, Hao Shi, Ning Huang, Junlin Teng, Jin Meng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Developmental regulation of X-chromosome inactivation [PDF]

Seminars in Cell & Developmental Biology, 2016
With the emergence of sex-determination by sex chromosomes, which differ in composition and number between males and females, appeared the need to equalize X-chromosomal gene dosage between the sexes. Mammals have devised the strategy of X-chromosome inactivation (XCI), in which one of the two X-chromosomes is rendered transcriptionally silent in ...
openaire   +3 more sources

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

X chromosome-encoded microRNAs in immune regulation: sex differences and clinical implications

Frontiers in Global Women's Health
Sex-based differences in immune function influence susceptibility to infections and predisposition to autoimmunity, with women showing both stronger immune responses and a higher burden of autoimmune and chronic inflammatory diseases.
Valeria Lodde, Valentina Margarita, Myriam Gorospe, Ilaria Campesi   +3 more
doaj   +1 more source

X-autosome and X-Y translocations in female carriers: X-chromosome inactivation easily detectable by 5-ethynyl-2-deoxyuridine (EdU)

Balkan Journal of Medical Genetics, 2017
Here we report one new case each of an X-autosome translocation (maternally derived), and an X-Y-chromosome translocation. Besides characterizing the involved breakpoints and/or imbalances in detail by molecular cyto-genetics, also skewed X-chromosome ...
Donat M, Louis A, Kreskowski K, Ziegler M, Weise A, Schreyer I, Liehr T   +6 more
doaj   +1 more source

Data for identification of porcine X-chromosome inactivation center, XIC, by genomic comparison with human and mouse XIC

Data in Brief, 2015
The data included in this article shows homologies of genes in porcine X-chromosome inactivation center, XIC, to each orthologue in human and mouse XIC.
Jae Yeon Hwang, Kwang-Hwan Choi, Chang-Kyu Lee   +2 more
doaj   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

X Chromosome Inactivation in Opioid Addicted Women

Basic and Clinical Neuroscience, 2015
Introduction: X chromosome inactivation (XCI) is a process during which one of the two X chromosomes in female human is silenced leading to equal gene expression with males who have only one X chromosome.
Nasim Vousooghi, Mitra-Sadat Sadat Shirazi, Ali Goodarzi, Peyman Hassani Abharian, Mohammad-Reza Zarrindast   +4 more
doaj  

The toll like receptor 7 pathway and the sex bias of systemic lupus erythematosus

Frontiers in Immunology
Systemic lupus erythematosus (SLE) predominately affects women with a ratio of females-to-males of about 9:1. The complement of sex chromosomes may play and important role in the mechanism of the sex bias.
R. Hal Scofield, R. Hal Scofield, R. Hal Scofield, Jonathan D. Wren, Valerie M. Lewis, Valerie M. Lewis, Valerie M. Lewis   +6 more
doaj   +1 more source