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Identification of Therapeutic Targets for Hyperuricemia: Systematic Genome-Wide Mendelian Randomization and Colocalization Analysis. [PDF]

Biomedicines
Chen N, Gong L, Zhang L, Li Y, Bai Y, Gao D, Zhang L.   +6 more
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New insights into purine metabolism in metabolic diseases: role of xanthine oxidoreductase activity.

American Journal of Physiology. Endocrinology and Metabolism, 2020
Xanthine oxidoreductase (XOR) consists of two different forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO), and is a rate-limiting enzyme of uric acid production from hypoxanthine and xanthine. Uric acid is the end-product of purine metabolism
M. Furuhashi
semanticscholar   +1 more source

A Dual-Emission Reverse Change Ratio Photoluminescence Sensor Based on Probe of N-doped Ti3C2 Quantum Dots@DAP to Detect H2O2 and Xanthine.

Analytical Chemistry, 2020
Titanium carbide quantum dots (Ti3C2 QDs) derived from 2D Ti3C2Tx (MXene) are the rising-star material recently. Herein, a nitrogen-doped Ti3C2 QDs (N-Ti3C2 QDs) were synthesized via a solvothermal method.
Q. Lu, Jing Wang, Bingzhi Li, Chenyuan Weng, Xiaoyun Li, Wei Yang, Xiaoqian Yan, Junli Hong, Wanying Zhu, Xuemin Zhou   +9 more
semanticscholar   +1 more source

Natural compounds with xanthine oxidase inhibitory activity: A review

Chemical Biology and Drug Design, 2019
Hyperuricemia (HUA), a disease due to an elevation of body uric acid level and responsible for various diseases such as gout, cardiovascular disorders, and renal failure, is a major ground debate for the medical science these days.
A. Mehmood, M. Ishaq, Lei Zhao, Bushra Safdar, A. Rehman, Masooma Munir, A. Raza, M. Nadeem, W. Iqbal, Chengtao Wang   +9 more
semanticscholar   +1 more source

Aromaticity of caffeine, xanthine and the dimethyl xanthines

Tetrahedron Letters, 2014
Xanthine, caffeine and three isomeric dimethyl xanthines (theobromine, theophylline and paraxanthine) are often described as aromatic on various criteria. Here we complete the picture by assessing these molecules for aromaticity on the ring-current criterion.
Patrick W. Fowler, Christopher M. Gibson
openaire   +2 more sources

The reactions of chloroperoxidase in the presence of xanthine/xanthine oxidase

Biochemical and Biophysical Research Communications, 1989
Spectral data are presented which indicate that chloroperoxidase is converted to compound II during the reaction with superoxide/hydrogen peroxide generated in the xanthine/xanthine oxidase system. Upon completion of compound II formation, compound II returns back to the native state of chloroperoxidase without formation of detectable intermediates. It
H. Brian Dunford, Diana Metodiewa, Michael A. Pickard   +2 more
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Palladium compounds of xanthine and xanthine derivatives

Inorganica Chimica Acta, 1983
The biological importance of purine bases is well known. The interaction of metal ions with nucleic acids, nucleotides and nucleotides has been an active area of inorganic and structural chemistry during the last few years, and a number of recent reviews exist on the subject [1, 2].
E. Colacio, Manuel Nogueras, M.A. Romero, Juan M. Salas, Adolfo Sánchez   +4 more
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Mammalian xanthine oxidoreductase – mechanism of transition from xanthine dehydrogenase to xanthine oxidase

The FEBS Journal, 2008
Reactive oxygen species are generated by various biological systems, including NADPH oxidases, xanthine oxidoreductase, and mitochondrial respiratory enzymes, and contribute to many physiological and pathological phenomena. Mammalian xanthine dehydrogenase (XDH) can be converted to xanthine oxidase (XO), which produces both superoxide anion and ...
Takeshi Nishino, Tomoko Nishino, Bryan T. Eger, Emil F. Pai, Ken Okamoto   +4 more
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Xanthine urolithiasis

Urology, 2006
Xanthine calculi are uncommonly encountered stones. When they occur, they typically do so in association with inborn metabolic disorders such as hereditary xanthinuria or Lesch-Nyhan syndrome. They may also occur in association with states of profound hyperuricemia such as myeloproliferative disease after treatment with allopurinol.
Vernon M, Pais, Gregory, Lowe, Costas D, Lallas, Glenn M, Preminger, Dean G, Assimos   +4 more
openaire   +2 more sources