Results 281 to 290 of about 89,320 (324)

Xanthine oxidase and xanthine dehydrogenase

The FASEB Journal, 1995
Xanthine oxidase and xanthine dehydrogenase are enzymes involved in the metabolism of purines and pyrimidines in various organisms. Their relationship to one another has been the subject of considerable debate, primarily because of their proposed roles in ischemia/reperfusion damage in tissues.
Takeshi Nishino, Russ Hille
openaire   +3 more sources

Novel insights into the inhibitory mechanism of kaempferol on xanthine oxidase.

Journal of Agricultural and Food Chemistry, 2015
Xanthine oxidase (XO), a key enzyme in purine catabolism, is widely distributed in human tissues. It can catalyze xanthine to generate uric acid and cause hyperuricemia and gout.
Yajie Wang, Guowen Zhang, Jun-hui Pan, D. Gong   +3 more
semanticscholar   +1 more source

Regulation of xanthine dehydrogenase and xanthine oxidase activity by hypoxia

American Journal of Physiology-Lung Cellular and Molecular Physiology, 1996
The present study determined the effect of hypoxia on xanthine dehydrogenase (XDH) and xanthine oxidase (XO) activity and gene and protein expression in cultured bovine aortic endothelial cells (BAEC). BAEC were exposed to hypoxia (3% O2) or anoxia (0% O2) for 24 or 48 h and to 24 h of hypoxia followed by 24 h of reoxygenation.
T. P. Huecksteadt, W. B. Poss, P. C. Panus, John R. Hoidal, B. A. Freeman   +4 more
openaire   +3 more sources

Non-Enzymatic Electrochemical Sensor for the Simultaneous Determination of Xanthine, its Methyl Derivatives Theophylline and Caffeine as well as its Metabolite Uric Acid

, 2017
Xanthine and its methyl derivatives, theophylline and caffeine are purines which find important roles in biological systems. The simultaneous voltammetric behaviour of these purines has been studied on a glassy carbon electrode modified with an ...
S. Jesny, K. D. Kumar
semanticscholar   +1 more source

Dietary Flavonoids as Xanthine Oxidase Inhibitors: Structure-Affinity and Structure-Activity Relationships.

Journal of Agricultural and Food Chemistry, 2015
The flavonoid family has been reported to possess a high potential for inhibition of xanthine oxidase (XO). This study concerned the structural aspects of inhibitory activities and binding affinities of flavonoids as XO inhibitors.
Suyun Lin, Guowen Zhang, Yi-jing Liao, Jun-hui Pan, D. Gong   +4 more
semanticscholar   +1 more source

Ischaemic Brain Oedema and Xanthine-Xanthine Oxidase System

1990
The formation of oxygen-derived free radicals in cerebral ischaemia has been implicated in altering the BBB permeability, cause oedema and tissue damage. However little attention has been paid regarding the involvement of xanthine oxidase in the cerebral ischaemic events.
Masatsune Ishikawa, Haruhiko Kikuchi, Kinuta Y   +2 more
openaire   +2 more sources

Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers.

Journal of Natural Products, 1998
The structure-activity relationship of flavonoids as inhibitors of xanthine oxidase and as scavengers of the superoxide radical, produced by the action of the enzyme xanthine oxidase, was investigated.
P. Cos, Li Ying, M. Calomme, Jia P. Hu, K. Cimanga, B. V. Poel, L. Pieters, A. Vlietinck, D. V. Berghe   +8 more
semanticscholar   +1 more source

X-ray crystal structure of a xanthine oxidase complex with the flavonoid inhibitor quercetin.

Journal of Natural Products, 2014
Xanthine oxidase catalyzes the sequential hydroxylation of hypoxanthine to uric acid via xanthine as intermediate. Deposition of crystals of the catalytic product uric acid or its monosodium salt in human joints with accompanying joint inflammation is ...
H. Cao, J. Pauff, R. Hille
semanticscholar   +1 more source

In vitro and in vivo studies on adlay-derived seed extracts: phenolic profiles, antioxidant activities, serum uric acid suppression, and xanthine oxidase inhibitory effects.

Journal of Agricultural and Food Chemistry, 2014
This study aimed to explore the potential of polished adlay, brown adlay, adlay bran, and adlay hull to prevent and treat hyperuricemia. Brown adlay extract effectively decreased the serum uric acid levels of oxonate-induced hyperuricemic rats.
Mouming Zhao, Dashuai Zhu, D. Sun-Waterhouse, G. Su, Lianzhu Lin, Xiao Wang, Yi Dong   +6 more
semanticscholar   +1 more source

Xanthine urolithiasis in a dachshund

Veterinary Record, 1998
Calculi were located in the kidneys, the ureters and the bladder of a two‐year‐old male dachshund. The yellow‐greenish calculi developed as a result of impaired transformation of xanthine to uric acid resulting in an increased concentration of xanthine in the urine.
R. Freistadt, T. Flegel, W. Haider
openaire   +3 more sources