Results 291 to 300 of about 89,320 (324)
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Journal of the American Pharmaceutical Association (Scientific ed.), 1952
An investigation was undertaken of the effect on the purine metabolism of the rat of 2-amino-4-hydroxy-6-formyl pteridine, known to inhibit xanthine oxidase, and sodium bromide, reported to retard uricopoiesis. Neither the intraperitoneal administration of the pteridine nor the oral administration of sodium bromide significantly lowered the tissue ...
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An investigation was undertaken of the effect on the purine metabolism of the rat of 2-amino-4-hydroxy-6-formyl pteridine, known to inhibit xanthine oxidase, and sodium bromide, reported to retard uricopoiesis. Neither the intraperitoneal administration of the pteridine nor the oral administration of sodium bromide significantly lowered the tissue ...
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Xanthine Oxidoreductase Inhibitors
2020Xanthine oxidase inhibitors are primarily used in the clinical prevention and treatment of gout associated with hyperuricemia. The archetypal xanthine oxidase inhibitor, Allopurinol has been shown to have other beneficial effects such as a reduction in vascular reactive oxygen species and mechano-energetic uncoupling.
Vickneson, Keeran, George, Jacob
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Xanthines and Phosphodiesterase Inhibitors
2016Theophylline is an orally acting xanthine that has been used since 1937 for the treatment of respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD). However, in most treatment guidelines, xanthines have now been consigned to third-line therapy because of their narrow therapeutic window and propensity for drug-drug ...
Clive P. Page, Domenico Spina
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Allopurinol and Xanthine Nephropathy
New England Journal of Medicine, 1970Treatment with allopurinol results in an induced xanthinuria. Allopurinol inhibits xanthine oxidase, the enzyme that catalyzes oxidation of hypoxanthine to xanthine and of xanthine to uric acid,1 a...
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Xanthines (Caffeine) and Nicotine
1989This chapter deals with the most culturally accepted legal drugs. As might be expected, these relatively mild (per usual dose) and highly attractive psychoactive substances have the widest use in our society. Despite the relatively benign effects that can be expected at low doses, the high prevalence of use results in frequent morbidity and (for ...
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Electrochemical Determination of Xanthine Oxidase-Catalyzed Oxidation of Xanthine
Analytical Letters, 1976Abstract A rapid electrochemical (chronoamperometric) method for the determination of xanthine oxidase catalyzed oxidation of xanthine and hypoxanthine is described. The assay is based on the anodic oxidation of the product, uric acid, at a stationary carbon paste electrode.
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