Results 281 to 290 of about 299,059 (319)

Dietary Flavonoids as Xanthine Oxidase Inhibitors: Structure-Affinity and Structure-Activity Relationships.

Journal of Agricultural and Food Chemistry, 2015
The flavonoid family has been reported to possess a high potential for inhibition of xanthine oxidase (XO). This study concerned the structural aspects of inhibitory activities and binding affinities of flavonoids as XO inhibitors.
Suyun Lin, Guowen Zhang, Yi-jing Liao, Jun-hui Pan, D. Gong   +4 more
semanticscholar   +1 more source

Nitrite reductase activity of rat and human xanthine oxidase, xanthine dehydrogenase, and aldehyde oxidase: evaluation of their contribution to NO formation in vivo.

Biochemistry, 2015
Nitrite is presently considered a NO "storage form" that can be made available, through its one-electron reduction, to maintain NO formation under hypoxia/anoxia. The molybdoenzymes xanthine oxidase/dehydrogenase (XO/XD) and aldehyde oxidase (AO) are two
L. Maia, Vânia Pereira, L. Mira, J. Moura   +3 more
semanticscholar   +1 more source

Xanthine Oxidase Studies†

Journal of the American Pharmaceutical Association (Scientific ed.), 1952
An investigation was undertaken of the effect on the purine metabolism of the rat of 2-amino-4-hydroxy-6-formyl pteridine, known to inhibit xanthine oxidase, and sodium bromide, reported to retard uricopoiesis. Neither the intraperitoneal administration of the pteridine nor the oral administration of sodium bromide significantly lowered the tissue ...
openaire   +3 more sources

X-ray crystal structure of a xanthine oxidase complex with the flavonoid inhibitor quercetin.

Journal of Natural Products, 2014
Xanthine oxidase catalyzes the sequential hydroxylation of hypoxanthine to uric acid via xanthine as intermediate. Deposition of crystals of the catalytic product uric acid or its monosodium salt in human joints with accompanying joint inflammation is ...
H. Cao, J. Pauff, R. Hille
semanticscholar   +1 more source

New insights into purine metabolism in metabolic diseases: role of xanthine oxidoreductase activity.

American Journal of Physiology. Endocrinology and Metabolism, 2020
Xanthine oxidoreductase (XOR) consists of two different forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO), and is a rate-limiting enzyme of uric acid production from hypoxanthine and xanthine. Uric acid is the end-product of purine metabolism
M. Furuhashi
semanticscholar   +1 more source

Xanthine oxidase and xanthine dehydrogenase

The FASEB Journal, 1995
Xanthine oxidase and xanthine dehydrogenase are enzymes involved in the metabolism of purines and pyrimidines in various organisms. Their relationship to one another has been the subject of considerable debate, primarily because of their proposed roles in ischemia/reperfusion damage in tissues.
Takeshi Nishino, Russ Hille
openaire   +3 more sources

In vitro and in vivo studies on adlay-derived seed extracts: phenolic profiles, antioxidant activities, serum uric acid suppression, and xanthine oxidase inhibitory effects.

Journal of Agricultural and Food Chemistry, 2014
This study aimed to explore the potential of polished adlay, brown adlay, adlay bran, and adlay hull to prevent and treat hyperuricemia. Brown adlay extract effectively decreased the serum uric acid levels of oxonate-induced hyperuricemic rats.
Mouming Zhao, Dashuai Zhu, D. Sun-Waterhouse, G. Su, Lianzhu Lin, Xiao Wang, Yi Dong   +6 more
semanticscholar   +1 more source

Bovine thyroidal xanthine oxidase

International Journal of Biochemistry, 1978
Abstract 1. 1. Xanthine oxidase from bovine thyroid glands was purified 1000-fold. Electrophoresis of the purified enzyme yielded a single enzymatically active band. 2. 2. A molecular weight of 260,000 ± 20,000 was estimated by gel filtration and by polyacrylamide gel electrophoresis. 3. 3.
Allan G. Fischer, Hyo-Sa Lee
openaire   +3 more sources

A Dual-Emission Reverse Change Ratio Photoluminescence Sensor Based on Probe of N-doped Ti3C2 Quantum Dots@DAP to Detect H2O2 and Xanthine.

Analytical Chemistry, 2020
Titanium carbide quantum dots (Ti3C2 QDs) derived from 2D Ti3C2Tx (MXene) are the rising-star material recently. Herein, a nitrogen-doped Ti3C2 QDs (N-Ti3C2 QDs) were synthesized via a solvothermal method.
Q. Lu, Jing Wang, Bingzhi Li, Chenyuan Weng, Xiaoyun Li, Wei Yang, Xiaoqian Yan, Junli Hong, Wanying Zhu, Xuemin Zhou   +9 more
semanticscholar   +1 more source

Myocardial xanthine oxidase/dehydrogenase

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1983
High-energy phosphates in heart muscle deprived of oxygen are rapidly broken down to purine nucleosides and oxypurines. We studied the role of xanthine oxidase/dehydrogenase (EC 1.2.3.2/EC 1.2.1.37) in this process with novel high-pressure liquid chromatographic techniques.
Peter P. De Tombe, Jan Willem De Jong, P. W. Achterberg, Bob Schoutsen, Eef Harmsen   +4 more
openaire   +3 more sources