Biotransformation of Xanthohumol by Entomopathogenic Filamentous Fungi
International Journal of Molecular SciencesXanthohumol (1) is a major prenylated flavonoid in hops (Humulus lupulus L.) which exhibits a broad spectrum of health-promoting and therapeutic activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer effects. However, due to its lipophilic nature, it is poorly soluble in water and barely absorbed from the gastrointestinal ...
Daniel Łój +4 more
openaire +2 more sources
O papel dos estrogénios e vias de sinalização do recetor de estrogénio no cancro e infertilidade associados a schistosomose [PDF]
, 2015 O Schistosoma haematobium é um verme parasita que infecta mais de 100 milhões de indivíduos, principalmente no mundo em desenvolvimento. É o agente causador da schistosomose urogenital e tem sido associado com alta incidência de carcinoma de células ...
Botelho, Mónica C.
core
Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus), Prevents Platelet Activation in Human Platelets [PDF]
, 2012 Xanthohumol is the principal prenylated flavonoid in the hop plant (Humulus lupulus L.). Xanthohumol was found to be a very potent cancer chemopreventive agent through regulation of diverse mechanisms.
Chou, Duen-Suey +7 more
core +3 more sources
Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads [PDF]
, 2016 Several compounds bearing the indolinone chemical scaffold are known to possess anticancer properties. For example, the tyrosine kinase inhibitor sunitinib is an arylideneindolin-2-one compound.
Arner, ES +8 more
core
Research in Pharmaceutical SciencesBackground and purpose: Xanthohumol (Xn), a small molecule found in Humulus lupulus, has shown promise as an anti-cancer compound. This in silico study was performed to understand the mechanism of action of Xn as a natural compound on MEK1/2 by ...
Zohreh Gholizadeh Siahmazgi +10 more
doaj +1 more source
Drug Design, Development and Therapy, 2020 Chuanhao Jiang,1,2,* Ning Xie,3,* Taoli Sun,4 Wanjun Ma,2 Bikui Zhang,2 Wenqun Li2 1Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of China; 2Department of ...
Jiang C +5 more
doaj
Introdução: O câncer de mama é um dos mais prevalentes entre as mulheres, apresentando desafios significativos no tratamento. O Xanthohumol (XN) tem demonstrado propriedades quimio-preventivas e quimioterápicas promissoras contra células de câncer de mama.
openaire +2 more sources
Generation of xanthohumol derivatives through fungi-mediated biotransformation
Natural Product ResearchXanthohumol (XTH, 1), a major prenylated chalcone in hops, has attracted considerable interests because of its pharmaceutical potency. To explore more related derivatives of XTH, its biotransformation was performed using the in vitro microbial model. Fungus Mucor sp. exhibited a robust biocatalytic feature to transform the substrate.
Yina, Xiao +5 more
openaire +2 more sources
THE IMPACT OF PLANT PROTECTION AND FERTILIZATION ON CONTENT OF BIOACTIVE SUBSTANCES IN ORGANIC HOPS
Acta Scientiarum Polonorum: Hortorum Cultus, 2015 Hop (Humulus lupulus) is one of the basic raw materials employed in brewing. All hops secondary metabolites exhibit pronounced bioactive effects. Therefore beer is the most important source of hop bioactive compounds in the human diet.
Ewa Solarska, Bożena Sosnowska
doaj
Development of a high-throughput LC-APCI-MS method for the determination of 13 phytoestrogens (including gut microbial metabolites) in human urine and serum [PDF]
, 2008 Bolca, Selin +3 more
core +2 more sources